"label" . "support departments page"@en . . . . _:N4e8462345c5c4c679225c5b9f912a7e8 "United Kingdom" . . . "Source"@en . . . "executive page"@en . . . _:N0e3ebe257d5349e5af0bb3b9a357f868 . . . . . "undergraduate courses page"@en . . "valid through (0..1)"@en . . . . . . . . "research postgraduate courses (or programmes) page"@en . . "Medical Sciences Division" . "has min currency value (1..1)"@en . . "email"@en . . . _:N4e8462345c5c4c679225c5b9f912a7e8 "Wellington Square" . . . . . . . "events page"@en . . . . . . . . . . . "43267"^^ . . "open days page"@en . . "Communicating the impact of your research" . "Formal Organization"@en . . . . . . . "Medical Sciences Division" . . . . "31076"^^ . "regulations page"@en . "Research Data Management Training (MANTRA)" . . . . . . . . . "Oxford University" . "comment" . "address"@en . . "Career Planning in the Sciences" . "tiene sede principal en"@es . . "Past vacancies at the University of Oxford" . . . . . . . . . . "7" . "28660"^^ . . . . . . . . . "notation"@en . . . . . "taught postgraduate admissions page"@en . . . . . . "undergraduate admissions page"@en . . "courses page"@en . . _:Nd8dbeb0011434c20a2cfaed5225dbda4 . . . . . . . _:Nb433e4dacc074bd385982edd97f26617 . "142433"^^ . . . "value" . """Job description and selection criteria Job title Postdoctoral Research Assistant in Cellular Biology or Immunology Division Medical Sciences Division Department Nuffield Department of Women’s and Reproductive Health Location Level 3, Women’s Centre, John Radcliffe Hospital, Headington, Oxford, OX3 9DU Grade and salary Grade 7: £31,076 - £38,183 p.a. (with a discretionary range up to £43,267) per annum Hours Full time (applications for flexible working arrangements are welcomed and will be considered in line with business needs) Contract type Fixed-term for 2 years in the first instance Reporting to Prof Krina Zondervan and Prof Christian Becker Vacancy reference 142411 The Post Overview of the role Uterine fibroids (UF), or leiomyomata, are benign tumours of the myometrium within the uterus, with an incidence in white and black women (aged 35-49) of approximately 70% and 80%, respectively (United States). In approximately 30% of patients the uterine fibroids cause heavy menstrual bleeding (HMB, >80 mL/day), and more than half of the patients experience symptoms such as HMB, pelvic pain, or infertility. Treatment consists of UF removal by laparoscopic excision or complete hysterectomy. In the United States, fibroids are cited to be the cause for over 50% of hysterectomies, and direct costs for their treatment is estimated between 4 and 9 billion USD. The University of Oxford and the Bayer AG have recently entered into the second phase of a strategic collaboration to identify and validate novel drug targets for endometriosis and uterine fibroids and PCOS. Bayer AG are a world leader in the field of hormonal contraception and a pioneer in women's healthcare focusing on innovations in contraception and gynaecological therapies. This strategic research alliance in the area of gynaecological therapies had originally been agreed on for a total of five years. Due to its success, it has just been extended for another three years. The multi-target collaboration focuses on endometriosis, uterine fibroids and PCOS with the goal of discovering and developing innovative treatment options for these diseases, which affect millions of women worldwide and are still poorly understood. Research projects will be jointly performed at the Bayer AG RD Centre in Berlin, Germany, and at several University of Oxford centres and institutes participating in the alliance. Samples are collected at the Oxford Endometriosis CaRe Centre within the Nuffield Department of Obstetrics & Gynaecology, John Radcliffe Hospital, using protocols for excess tissue use from the Oxford Radcliffe Biobank, the FENOX (Fibroids and Endometriosis Oxford) and PCOS Study headed by the Centre directors Prof Krina Zondervan and Prof Christian Becker as well as Prof Cecilia Lindgren and Dr Ingrid Granne. The holder of the position will primarily be responsible for the vascular targets approach and will be working closely together with the team of the systems biology branch of the project. In addition, the holder will be expected to work on other projects as required. Clinical and research expertise in uterine fibroids, endometriosis and PCOS will be provided by the Oxford Endometriosis CaRe Centre. The position holder will also be working closely with the group of Prof Adrian Harris at the Weatherall Institute for Molecular Medicine (WIMM), Department of Oncology, where angiogenesis assays, the culturing and analysis of vasculature and angiogenic factors will be done. Target discovery and pre-clinical validation will be performed by the Target Discovery Institute under the lead of Prof Benedikt Kessler together with the Botnar – Kennedy Tissue platform located at the Botnar Research Centre (Prof Udo Oppermann). The Postdoctoral Research Assistant will conduct research in a project aiming to validate novel targets in the vasculature surrounding uterine fibroids. The newly developed PCOS strategy will allow further investigation of molecular and genetic pathways. The successful candidate will join a highly motivated interdisciplinary team of scientists and clinical researchers working in the 2 field of reproductive medicine conducting research at the interface between academia and industry, with the central aim to identify new drug targets in an area of great unmet clinical need. They will benefit from state-of-the-art facilities and opportunities offered by the different collaborating departments. Publication of the work in leading peer-reviewed journals is strongly encouraged by all parties of the collaboration. Responsibilities  Initiate and conduct experiments that aim to identify and characterise the role of novel targets in inflammatory processes, and analyse their results.  Further develop and establish relevant cell isolation/processing protocols from collected biological tissue and fluid samples.  Further develop in vitro follow-up experiments using the isolated samples.  Work in a team environment, helping out with sample preparation if necessary.  Take responsibility for the planning and execution of high-quality research, ensuring the validity and reliability of data at all times.  Contribute ideas and communicate effectively with the Oxford research groups and researchers in the Oxford-Bayer alliance.  Maintain accurate and up-to-date records of all findings, and to make these available to other members of the team.  Ensure written communication of experimental reports and data deposition in the electronic laboratory notebook (ELN) and database.  Actively participate in meetings at group and cross-departmental levels.  Maintain an up-to-date awareness of relevant publications in the area of research.  Initiate, prepare and submit publications relevant to own research project, and aid the preparation of other publications.  Assist in writing reports for the research sponsor.  Contribute to the success of the Oxford-Bayer alliance and the Endometriosis CaRe Centre by continued development of own skills and to assist others where required.  Foster collaborative interactions with other groups within the University of Oxford and the wider scientific community.  Provide guidance, supervision and support to PhD/DPhil students and other members of the group.  Attend, and present data at relevant conferences, workshops, training courses and collaboration meetings where necessary.  Comply with local, departmental and university-wide safety and data regulations.  Willingness to work out of normal working hours (including weekends) if the requirements of the project demand. 3 Hazard-specific / Safety-critical duties: This job includes the following hazards or safety-critical activities which will require successful pre-employment health screening through our Occupational Health Service before the successful candidate will be allowed to start work:  Night working (11pm-6am)  Lone Working  Working with blood, human products and human tissues Pre-employment screening All offers of employment are made subject to standard pre-employment screening, as applicable to the post. If you are offered the post, you will be asked to provide proof of your right-to-work, your identity, and we will contact the referees you have nominated. You will also be asked to complete a health declaration (so that you can tell us about any health conditions or disabilities so that we can discuss appropriate adjustments with you), and a declaration of any unspent criminal convictions. We advise all applicants to read the candidate notes on the University’s pre-employment screening procedures, found at: www.ox.ac.uk/about/jobs/preemploymentscreening/. Selection criteria Applications will be judged only against the criteria that are set out below. Applicants should ensure that their application shows very clearly how their skills and experience meet these criteria. Essential 1. PhD (or close to completion) in Cell Biology, Biochemistry, Molecular Biology, Molecular Medicine or Immunology 2. Capacity to deliver high quality research outputs, as illustrated by at least two first author papers in a peer-reviewed journal 3. Good spoken and written communication skills and the ability to communicate results effectively in writing and verbally with colleagues in any discipline 4. Self-motivated and with good organisation and time management skills 5. Ability to work independently within multi-disciplinary teams 6. Flexibility to learn new skills and develop novel approaches for analysis 7. Attention to detail 8. Ability to work effectively under pressure 9. Knowledgeable in: a. endothelial cell biology in normal and pathological circumstances, ideally in normal and tumour vasculature biology 4 b. biology of inflammatory cells c. cell isolation and culture techniques d. confocal or multiphoton microscopy e. bioinformatics skills and documented experience in the analysis of complex datasets f. understanding of proteomics analysis using LCMS/MS Desirable 1. Immunohistochemistry 2. Laser capture microscopy 3. Angiogenesis assays 4. Understanding of next genome bulk and single cell sequencing 5. Image analysis skills (Image J, Imaris or similar) 6. Knowledge of the biology of uterine fibroids, endometriosis and/or PCOS 7. Experience of working in a University environment How to apply Before submitting an application, you may find it helpful to read the ‘Tips on applying for a job at the University of Oxford’ document, at http://www.ox.ac.uk/about_the_university/jobs/professionalandmanagement/ If you would like to apply, click on the Apply Now button on the ‘Job Details’ page and follow the on-screen instructions to register as a new user or log-in if you have applied previously. Please provide details of three referees and indicate whether we can contact them now. You will also be asked to upload a CV and a supporting statement. The supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. This may include experience gained in employment, education, or during career breaks (such as time out to care for dependants). Your application will be judged solely on the basis of how you demonstrate that you meet the selection criteria stated in the job description. Please note that if you do not upload a supporting statement, we will be unable to consider your application. Please upload all documents as PDF files with your name and the document type in the filename. All applications must be received by midday on the closing date stated in the online advertisement. 5 Information for priority candidates A priority candidate is a University employee who is seeking redeployment because they have been advised that they are at risk of redundancy, or on grounds of ill-health/disability. Priority candidates are issued with a redeployment letter by their employing departments. If you are a priority candidate, please ensure that you attach your redeployment letter to your application (or email it to the contact address on the advert if the application form used for the vacancy does not allow attachments) Should you experience any difficulties using the online application system, please email recruitment.support@admin.ox.ac.uk. Further help and support is available from www.ox.ac.uk/about_the_university/jobs/support/. To return to the online application at any stage, please go to: www.recruit.ox.ac.uk. Please note that you will be notified of the progress of your application by automatic emails from our e-recruitment system. Please check your spam/junk mail regularly to ensure that you receive all emails. Important information for candidates Data Privacy Please note that any personal data submitted to the University as part of the job application process will be processed in accordance with the GDPR and related UK data protection legislation. For further information, please see the University’s Privacy Notice for Job Applicants at: www.admin.ox.ac.uk/councilsec/compliance/gdpr/privacynotices/job/. The University’s Policy on Data Protection is available at: www.admin.ox.ac.uk/councilsec/compliance/gdpr/ universitypolicyondataprotection/. The University’s policy on retirement The University operates an Employer Justified Retirement Age (EJRA) for all academic posts and some academic-related posts. From 1 October 2017, the University has adopted an EJRA of 30 September before the 69th birthday for all academic and academic-related staff in posts at grade 8 and above. The justification for this is explained at: www.admin.ox.ac.uk/personnel/ end/retirement/acrelretire8+/. For existing employees, any employment beyond the retirement age is subject to approval through the procedures: www.admin.ox.ac.uk/personnel/end/retirement/acrelretire8+/. From 1 October 2017, there is no normal or fixed age at which staff in posts at grades 1–7 have to retire. Staff at these grades may elect to retire in accordance with the rules of the applicable pension scheme, as may be amended from time to time. Equality of Opportunity Entry into employment with the University and progression within employment will be determined only by personal merit and the application of criteria which are related to the duties of each particular post and the relevant salary structure. In all cases, ability to perform the job 6 will be the primary consideration. No applicant or member of staff shall be discriminated against because of age, disability, gender reassignment, marriage or civil partnership, pregnancy or maternity, race, religion or belief, sex, or sexual orientation. About the University of Oxford Welcome to the University of Oxford. We aim to lead the world in research and education for the benefit of society both in the UK and globally. Oxford’s researchers engage with academic, commercial and cultural partners across the world to stimulate high-quality research and enable innovation through a broad range of social, policy and economic impacts. We believe our strengths lie both in empowering individuals and teams to address fundamental questions of global significance, while providing all our staff with a welcoming and inclusive workplace that enables everyone to develop and do their best work. Recognising that diversity is our strength, vital for innovation and creativity, we aspire to build a truly diverse community which values and respects every individual’s unique contribution. While we have long traditions of scholarship, we are also forward-looking, creative and cuttingedge. Oxford is one of Europe's most entrepreneurial universities. Income from external research contracts in 2016/17 exceeded £564m and we rank first in the UK for university spinouts, with more than 130 companies created to date. We are also recognised as leaders in support for social enterprise. Join us and you will find a unique, democratic and international community, a great range of staff benefits and access to a vibrant array of cultural activities in the beautiful city of Oxford. For more information please visit www.ox.ac.uk/about/organisation Nuffield Department of Women’s & Reproductive Health (NDWRH) The Nuffield Department of Women’s & Reproductive Health (NDWRH) is one of the largest and most successful academic departments in the world in its field. There are approximately 160 people working in the department, including senior academic staff, research support staff, clerical and technical staff, and graduate students (including clinicians) carrying out research towards a higher degree. There are also a number of visiting researchers from many parts of the world. The average annual income is approximately £10 million, of which over 75% comes from outside sources. NDWRH encompasses multi-disciplinary research across the full spectrum of women’s health. Our work has four overarching themes; Cancer, Global Health, Maternal & Fetal Health and Reproductive Medicine & Genetics. We focus on genetic studies, the dissection of molecular, biochemical and cellular mechanisms underlying normal and aberrant reproductive tissue function, and clinical studies in women’s health, assisted reproduction and pregnancy, as well as growth and development across the first 1000 days of life. The department also now includes The George Institute for Global Health, whose mission is to increase access to quality health care for millions of people worldwide - with a particular focus on vulnerable women in resource-poor settings. The clinical and laboratory programmes are based in the Women’s Centre, John Radcliffe Hospital; Weatherall Institute of Molecular Medicine; Winchester House, and the Big Data 7 Institute, and there are collaborations with the School’s Institutes, the University’s Science Departments and with researchers outside Oxford, in both the UK and abroad, especially in lowmiddle income countries. For more information please visit: www.wrh.ox.ac.uk The University of Oxford is a member of the Athena SWAN Charter and holds an institutional Bronze Athena SWAN award. NDWRH holds a departmental Silver Athena award in recognition of its efforts to introduce organisational and cultural practices that promote gender equality in SET and create a better working environment for both men and women. 8 Benefits of working at the University Employee benefits University employees enjoy 38 days’ paid holiday, generous pension schemes, travel discounts, and a variety of professional development opportunities. Our range of other employee benefits and discounts also includes free entry to the Botanic Gardens and University colleges, and discounts at University museums. See www.admin.ox.ac.uk/personnel/staffinfo/benefits. University Club and sports facilities Membership of the University Club is free for all University staff. The University Club offers social, sporting, and hospitality facilities. Staff can also use the University Sports Centre on Iffley Road at discounted rates, including a fitness centre, powerlifting room, and swimming pool. See www.club.ox.ac.uk and www.sport.ox.ac.uk/oxford-university-sports-facilities. Information for staff new to Oxford If you are relocating to Oxfordshire from overseas or elsewhere in the UK, the University's Welcome Service website includes practical information about settling in the area, including advice on relocation, accommodation, and local schools. See www.welcome.ox.ac.uk. There is also a visa loan scheme to cover the costs of UK visa applications for staff and their dependents. See www.admin.ox.ac.uk/personnel/permits/reimburse&loanscheme/. Family-friendly benefits With one of the most generous family leave schemes in the Higher Education sector, and a range of flexible working options, Oxford aims to be a family-friendly employer. We also subscribe to My Family Care, a service that provides practical advice and support for employees who have caring responsibilities. The service offers a free telephone advice line, and the ability to book emergency back-up care for children, adult dependents and elderly relatives. See www.admin.ox.ac.uk/personnel/staffinfo/benefits/family/mfc/. Childcare The University has excellent childcare services, including five University nurseries as well as University-supported places at many other private nurseries. For full details, including how to apply and the costs, see www.admin.ox.ac.uk/childcare/. Disabled staff We are committed to supporting members of staff with disabilities or long-term health conditions. For further details, including information about how to make contact, in confidence, with the University’s Staff Disability Advisor, see www.admin.ox.ac.uk/eop/disab/staff. Staff networks The University has a number of staff networks including the Oxford Research Staff Society, BME staff network, LGBT+ staff network and a disabled staff network. You can find more information at www.admin.ox.ac.uk/eop/inpractice/networks/. The University of Oxford Newcomers' Club The University of Oxford Newcomers' Club is an organisation run by volunteers that aims to assist the partners of new staff settle into Oxford, and provides them with an opportunity to meet people and make connections in the local area. See www.newcomers.ox.ac.uk. 9 """^^ . . . "press page"@en . . . . . "GBP" . "sous-Organization de"@fr . . . "homepage" . . . . "Grade 7: £31,076 - £38,183 with a discretionary range to £43,267 p.a." . . "has site"@en . . . . . "undergraduate courses entry requirements page"@en . "ICO publication scheme"@en . . "142411"^^ . . . . "name" . . . "open data page"@en . . . "Research Integrity: Natural and Physical Sciences" . . . "site principal"@fr . . . . _:Nb433e4dacc074bd385982edd97f26617 . . "contact page"@en . "Research Integrity: Biomedical Sciences" . "research page"@en . . . . "in dataset" . . . "freedom-of-information policy page"@en . . "Nuffield Department of Obstetrics and Gynaecology" . . "ICT support page"@en . . . . "tiene sede en"@es . "Postdoctoral Research Assistant in Cellular Biology or Immunology" . _:Nfd19c71f6b794ad98e604feb3a90b11b "Headington" . . . "Subject"@en . """

The University of Oxford and the Bayer AG have recently entered into the second phase of a strategic collaboration to identify and validate novel drug targets for endometriosis and uterine fibroids and PCOS. Bayer AG are a world leader in the field of hormonal contraception and a pioneer in women's healthcare focusing on innovations in contraception and gynaecological therapies.


The Nuffield Department of Women’s & Reproductive Health are seeking a Postdoctoral Research Assistant to conduct research in a project aiming to validate novel targets in the vasculature surrounding uterine fibroids. The newly developed PCOS strategy will allow further investigation of molecular and genetic pathways. The successful candidate will join a highly motivated interdisciplinary team of scientists and clinical researchers working in the field of reproductive medicine conducting research at the interface between academia and industry, with the central aim to identify new drug targets in an area of great unmet clinical need. They will benefit from state-of-the-art facilities and opportunities offered by the different collaborating departments. Publication of the work in leading peer-reviewed journals is strongly encouraged by all parties of the collaboration.


The postholder will hold a PhD (or close to completion) in cell biology, biochemistry, molecular biology, molecular medicine or immunology. The capacity to deliver high quality research outputs, as illustrated by at least two first author papers in a peer-reviewed journal is also essential. The postholder will also have good spoken and written communication skills, be self-motivated with good organisation and time management skills, have the ability to work independently within multi-disciplinary teams and be able to work well under pressure.


This post will be based at Level 3, Women’s Centre, John Radcliffe Hospital, Headington, Oxford.


This post is full-time and fixed-term for 2 years. Applications for flexible working arrangements are welcomed and will be considered in line with business needs.


You will be required to upload a CV and supporting statement as part of your online application.


The closing date for applications is 12.00 noon on Monday 16 September 2019.

"""^^ . . . . . . "The Imposter Syndrome (strategies for building confidence in your work - or why successful people often feel like frauds)" . . "Turbocharge Your Writing" . . . "false"^^ . "false"^^ . . "organización formal"@es . . . . . . . . . . . . . . . "Using Your Brain - Grad Challenge 2015" . . . . . "Nuffield Department of Women’s and Reproductive Health, Level 3, Women’s Centre, John Radcliffe Hospital, Headington, Oxford" . . . "conference facilities page"@en . . "142411 Postdoc_August 2019" . _:N4e8462345c5c4c679225c5b9f912a7e8 "Oxford" . . . . "Research Integrity: Engineering and Technology" . . . "extended address"@en . _:N4e8462345c5c4c679225c5b9f912a7e8 . . . . "University of Oxford" . _:N4e8462345c5c4c679225c5b9f912a7e8 "OX1 2JD" . "University of Oxford" . . . _:Nb433e4dacc074bd385982edd97f26617 "+44-1865-270000" . . . . . "Career Planning in the Arts, Humanities and Social Sciences" . _:Nd8dbeb0011434c20a2cfaed5225dbda4 . . "telephone"@en . . . . "about page"@en . "2019-08-19T09:00:00+01:00"^^ . . . . . . . "Unit price specification"@en . "Fax"@en . . _:Nfd19c71f6b794ad98e604feb3a90b11b . "has primary place" . "based near" . . . . . . . "Oxford, University of" . "occupies" . . . _:Nfd19c71f6b794ad98e604feb3a90b11b "OX3 9DU" . . "Address"@en . . _:Nfd19c71f6b794ad98e604feb3a90b11b "Oxford" . . "taught postgraduate courses page"@en . . "Oxford Institute of Reproductive Sciences" . . . . . "has exact match"@en . _:N0e3ebe257d5349e5af0bb3b9a357f868 "+44-1865-270708" . "department" . . "Research Integrity: Arts and Humanities" . "OxPoints"@en . . . . "Recruitment Administrator" . . "Nuffield Department of Women's and Reproductive Health" . . . . . "Nuffield Department of Women’s & Reproductive Health, Level 3, Women’s Centre, John Radcliffe Hospital, Headington, Oxford" . . "logo" . . . "The Seven Secrets of Highly Successful Research Students" . . "Organization" . "Title"@en . "Organisation Formelle"@fr . . "jobs page"@en . . . . "Avoiding Plagiarism 2" . _:N4e8462345c5c4c679225c5b9f912a7e8 . "HE"^^ . "staff contact page"@en . . "Is Part Of"@en . """The Nuffield Department of Women’s and Reproductive Health is seeking an experienced, enthusiastic and motivated Midwife to work in the department on NIHR portfolio research. NIHR portfolio studies are high-quality clinical research studies that are eligible for support from the NIHR Clinical Research Network in England. Working under the supervision of the OSPREA and Gynaecology Clinical Research Manager and alongside NIHR portfolio midwives, you will be responsible for facilitating NIHR portfolio recruitment in the area of reproductive health. The postholder will contribute to the set-up, overseeing, co-ordination and facilitation of a caseload of concurrent NIHR CRN portfolio research studies. In addition to clinical and patient related tasks, this role includes document generation and control, project tracking and logistics, data collection and patient recruitment accrual reporting as well as trial management responsibilities. The postholder will provide specialist advice to participants on all aspects of their involvement in trials, including identification, advising and proper reporting of any adverse events. The postholder will contribute to development of the speciality service to trial participants and ensure cost effective use of resources. You will be a registered general midwife with an extensive midwifery background. Knowledge of trials regulations and regulatory processes is also essential. You will possess good interpersonal skills, good written and oral communication skills and have the ability to work independently and unsupervised. The postholder will also be accurate, computer literate, highly organised with a methodological approach to work and be able to maintain confidentiality. This post will be based at The Women's Centre, John Radcliffe Hospital, Oxford. This post is full-time and fixed-term for 1 year in the first instance. Applications for flexible working arrangements are welcomed and will be considered in line with business needs. You will be required to upload a CV and supporting statement as part of your online application. The closing date for applications is 12.00 noon on Monday 16 September 2019. """ . . . . . . "Oxford, University of" . . "has max currency value (1..1)"@en . "37345"^^ . "Nuffield Department of Women's and Reproductive Health" . . "2019-09-16T12:00:00+01:00"^^ . . "Research Midwife" . . "has currency (1..1)"@en . "Agent" . . . . "6" . . "preferred label"@en . _:Nd8dbeb0011434c20a2cfaed5225dbda4 . "primary Site"@en . . . . . . . "finance code" . "equality policy page"@en . . . _:Nd8dbeb0011434c20a2cfaed5225dbda4 . . "ha sede"@it . _:Nd8dbeb0011434c20a2cfaed5225dbda4 . . . . . "01865 221002" . . "John Radcliffe Women's Centre" . _:Nfd19c71f6b794ad98e604feb3a90b11b "John Radcliffe Hospital Women's Centre, Headley Way" . . . """

The Nuffield Department of Women’s and Reproductive Health is seeking an experienced, enthusiastic and motivated Midwife to work in the department on NIHR portfolio research. NIHR portfolio studies are high-quality clinical research studies that are eligible for support from the NIHR Clinical Research Network in England.


Working under the supervision of the OSPREA and Gynaecology Clinical Research Manager and alongside NIHR portfolio midwives, you will be responsible for facilitating NIHR portfolio recruitment in the area of reproductive health. The postholder will contribute to the set-up, overseeing, co-ordination and facilitation of a caseload of concurrent NIHR CRN portfolio research studies. In addition to clinical and patient related tasks, this role includes document generation and control, project tracking and logistics, data collection and patient recruitment accrual reporting as well as trial management responsibilities.


The postholder will provide specialist advice to participants on all aspects of their involvement in trials, including identification, advising and proper reporting of any adverse events. The postholder will contribute to development of the speciality service to trial participants and ensure cost effective use of resources.


You will be a registered general midwife with an extensive midwifery background. Knowledge of trials regulations and regulatory processes is also essential. You will possess good interpersonal skills, good written and oral communication skills and have the ability to work independently and unsupervised. The postholder will also be accurate, computer literate, highly organised with a methodological approach to work and be able to maintain confidentiality.


This post will be based at The Women's Centre, John Radcliffe Hospital, Oxford.


This post is full-time and fixed-term for 1 year in the first instance. Applications for flexible working arrangements are welcomed and will be considered in line with business needs.


You will be required to upload a CV and supporting statement as part of your online application.


The closing date for applications is 12.00 noon on Monday 16 September 2019.

"""^^ . "academic departments page"@en . . "leader page"@en . . "OxPoints"@en . . . . "country name"@en . . . _:N0e3ebe257d5349e5af0bb3b9a357f868 . . . . "License"@en . . . "postal code"@en . "OUCS code" . "2019-08-19T09:00:00+01:00"^^ . "a un site"@fr . . "type" . "2019-09-16T12:00:00+01:00"^^ . . . . . . "research postgraduate admissions page"@en . "Organizzazione formale"@it . "ICT policy page"@en . . . . . . . . . . . "How to Plan Your PhD" . . . . "obst" . . . """The University of Oxford and the Bayer AG have recently entered into the second phase of a strategic collaboration to identify and validate novel drug targets for endometriosis and uterine fibroids and PCOS. Bayer AG are a world leader in the field of hormonal contraception and a pioneer in women's healthcare focusing on innovations in contraception and gynaecological therapies. The Nuffield Department of Women’s & Reproductive Health are seeking a Postdoctoral Research Assistant to conduct research in a project aiming to validate novel targets in the vasculature surrounding uterine fibroids. The newly developed PCOS strategy will allow further investigation of molecular and genetic pathways. The successful candidate will join a highly motivated interdisciplinary team of scientists and clinical researchers working in the field of reproductive medicine conducting research at the interface between academia and industry, with the central aim to identify new drug targets in an area of great unmet clinical need. They will benefit from state-of-the-art facilities and opportunities offered by the different collaborating departments. Publication of the work in leading peer-reviewed journals is strongly encouraged by all parties of the collaboration. The postholder will hold a PhD (or close to completion) in cell biology, biochemistry, molecular biology, molecular medicine or immunology. The capacity to deliver high quality research outputs, as illustrated by at least two first author papers in a peer-reviewed journal is also essential. The postholder will also have good spoken and written communication skills, be self-motivated with good organisation and time management skills, have the ability to work independently within multi-disciplinary teams and be able to work well under pressure. This post will be based at Level 3, Women’s Centre, John Radcliffe Hospital, Headington, Oxford. This post is full-time and fixed-term for 2 years. Applications for flexible working arrangements are welcomed and will be considered in line with business needs. You will be required to upload a CV and supporting statement as part of your online application. The closing date for applications is 12.00 noon on Monday 16 September 2019. """ . "website legal information page"@en . . . . . . . "GBP" . . "sotto-Organization di"@it . "press facts page"@en . "hidden label"@en . . . . "2019-09-16T12:00:00+01:00"^^ . "graduation event page"@en . "homepage"@en . _:Nfd19c71f6b794ad98e604feb3a90b11b . . . "2B04"^^ . . "data-protection statement page"@en . _:Nd8dbeb0011434c20a2cfaed5225dbda4 . . "23232645"^^ . "John Radcliffe Women's Centre" . . . "obst"^^ . "subOrganization of"@en . "2B04" . . "00000000"^^ . "alternative label"@en . . . . . . "spatial acessibility"@en . "es suborganización de"@es . . "University of Oxford" . . . "business incubation page"@en . . . . . "sede principale"@it . "Avoiding Plagiarism 1" . "strategy page"@en . . "false"^^ . "Subject"@en . . . . "news page"@en . . . . . "locality"@en . "business page"@en . . "university" . "Research Integrity: Social and Behavioural Sciences" . "2019-09-16T12:00:00+01:00"^^ . . . . "departments page"@en . "The Balanced Researcher (strategies for busy researchers)" . . "street address"@en . "sites page"@en . _:Nd8dbeb0011434c20a2cfaed5225dbda4 . . . . "HE" . . . "true"^^ . "Oxford Institute of Reproductive Sciences" . . "Recruitment Administrator" . . """Job description and selection criteria Job title Postdoctoral Research Assistant in Cellular Biology or Immunology Division Medical Sciences Division Department Nuffield Department of Women’s and Reproductive Health Location Level 3, Women’s Centre, John Radcliffe Hospital, Headington, Oxford, OX3 9DU Grade and salary Grade 7: £31,076 - £38,183 p.a. (with a discretionary range up to £43,267) per annum Hours Full time (applications for flexible working arrangements are welcomed and will be considered in line with business needs) Contract type Fixed-term for 2 years in the first instance Reporting to Prof Krina Zondervan and Prof Christian Becker Vacancy reference 142411 The Post Overview of the role Uterine fibroids (UF), or leiomyomata, are benign tumours of the myometrium within the uterus, with an incidence in white and black women (aged 35-49) of approximately 70% and 80%, respectively (United States). In approximately 30% of patients the uterine fibroids cause heavy menstrual bleeding (HMB, >80 mL/day), and more than half of the patients experience symptoms such as HMB, pelvic pain, or infertility. Treatment consists of UF removal by laparoscopic excision or complete hysterectomy. In the United States, fibroids are cited to be the cause for over 50% of hysterectomies, and direct costs for their treatment is estimated between 4 and 9 billion USD. The University of Oxford and the Bayer AG have recently entered into the second phase of a strategic collaboration to identify and validate novel drug targets for endometriosis and uterine fibroids and PCOS. Bayer AG are a world leader in the field of hormonal contraception and a pioneer in women's healthcare focusing on innovations in contraception and gynaecological therapies. This strategic research alliance in the area of gynaecological therapies had originally been agreed on for a total of five years. Due to its success, it has just been extended for another three years. The multi-target collaboration focuses on endometriosis, uterine fibroids and PCOS with the goal of discovering and developing innovative treatment options for these diseases, which affect millions of women worldwide and are still poorly understood. Research projects will be jointly performed at the Bayer AG RD Centre in Berlin, Germany, and at several University of Oxford centres and institutes participating in the alliance. Samples are collected at the Oxford Endometriosis CaRe Centre within the Nuffield Department of Obstetrics & Gynaecology, John Radcliffe Hospital, using protocols for excess tissue use from the Oxford Radcliffe Biobank, the FENOX (Fibroids and Endometriosis Oxford) and PCOS Study headed by the Centre directors Prof Krina Zondervan and Prof Christian Becker as well as Prof Cecilia Lindgren and Dr Ingrid Granne. The holder of the position will primarily be responsible for the vascular targets approach and will be working closely together with the team of the systems biology branch of the project. In addition, the holder will be expected to work on other projects as required. Clinical and research expertise in uterine fibroids, endometriosis and PCOS will be provided by the Oxford Endometriosis CaRe Centre. The position holder will also be working closely with the group of Prof Adrian Harris at the Weatherall Institute for Molecular Medicine (WIMM), Department of Oncology, where angiogenesis assays, the culturing and analysis of vasculature and angiogenic factors will be done. Target discovery and pre-clinical validation will be performed by the Target Discovery Institute under the lead of Prof Benedikt Kessler together with the Botnar – Kennedy Tissue platform located at the Botnar Research Centre (Prof Udo Oppermann). The Postdoctoral Research Assistant will conduct research in a project aiming to validate novel targets in the vasculature surrounding uterine fibroids. The newly developed PCOS strategy will allow further investigation of molecular and genetic pathways. The successful candidate will join a highly motivated interdisciplinary team of scientists and clinical researchers working in the 2 field of reproductive medicine conducting research at the interface between academia and industry, with the central aim to identify new drug targets in an area of great unmet clinical need. They will benefit from state-of-the-art facilities and opportunities offered by the different collaborating departments. Publication of the work in leading peer-reviewed journals is strongly encouraged by all parties of the collaboration. Responsibilities  Initiate and conduct experiments that aim to identify and characterise the role of novel targets in inflammatory processes, and analyse their results.  Further develop and establish relevant cell isolation/processing protocols from collected biological tissue and fluid samples.  Further develop in vitro follow-up experiments using the isolated samples.  Work in a team environment, helping out with sample preparation if necessary.  Take responsibility for the planning and execution of high-quality research, ensuring the validity and reliability of data at all times.  Contribute ideas and communicate effectively with the Oxford research groups and researchers in the Oxford-Bayer alliance.  Maintain accurate and up-to-date records of all findings, and to make these available to other members of the team.  Ensure written communication of experimental reports and data deposition in the electronic laboratory notebook (ELN) and database.  Actively participate in meetings at group and cross-departmental levels.  Maintain an up-to-date awareness of relevant publications in the area of research.  Initiate, prepare and submit publications relevant to own research project, and aid the preparation of other publications.  Assist in writing reports for the research sponsor.  Contribute to the success of the Oxford-Bayer alliance and the Endometriosis CaRe Centre by continued development of own skills and to assist others where required.  Foster collaborative interactions with other groups within the University of Oxford and the wider scientific community.  Provide guidance, supervision and support to PhD/DPhil students and other members of the group.  Attend, and present data at relevant conferences, workshops, training courses and collaboration meetings where necessary.  Comply with local, departmental and university-wide safety and data regulations.  Willingness to work out of normal working hours (including weekends) if the requirements of the project demand. 3 Hazard-specific / Safety-critical duties: This job includes the following hazards or safety-critical activities which will require successful pre-employment health screening through our Occupational Health Service before the successful candidate will be allowed to start work:  Night working (11pm-6am)  Lone Working  Working with blood, human products and human tissues Pre-employment screening All offers of employment are made subject to standard pre-employment screening, as applicable to the post. If you are offered the post, you will be asked to provide proof of your right-to-work, your identity, and we will contact the referees you have nominated. You will also be asked to complete a health declaration (so that you can tell us about any health conditions or disabilities so that we can discuss appropriate adjustments with you), and a declaration of any unspent criminal convictions. We advise all applicants to read the candidate notes on the University’s pre-employment screening procedures, found at: www.ox.ac.uk/about/jobs/preemploymentscreening/. Selection criteria Applications will be judged only against the criteria that are set out below. Applicants should ensure that their application shows very clearly how their skills and experience meet these criteria. Essential 1. PhD (or close to completion) in Cell Biology, Biochemistry, Molecular Biology, Molecular Medicine or Immunology 2. Capacity to deliver high quality research outputs, as illustrated by at least two first author papers in a peer-reviewed journal 3. Good spoken and written communication skills and the ability to communicate results effectively in writing and verbally with colleagues in any discipline 4. Self-motivated and with good organisation and time management skills 5. Ability to work independently within multi-disciplinary teams 6. Flexibility to learn new skills and develop novel approaches for analysis 7. Attention to detail 8. Ability to work effectively under pressure 9. Knowledgeable in: a. endothelial cell biology in normal and pathological circumstances, ideally in normal and tumour vasculature biology 4 b. biology of inflammatory cells c. cell isolation and culture techniques d. confocal or multiphoton microscopy e. bioinformatics skills and documented experience in the analysis of complex datasets f. understanding of proteomics analysis using LCMS/MS Desirable 1. Immunohistochemistry 2. Laser capture microscopy 3. Angiogenesis assays 4. Understanding of next genome bulk and single cell sequencing 5. Image analysis skills (Image J, Imaris or similar) 6. Knowledge of the biology of uterine fibroids, endometriosis and/or PCOS 7. Experience of working in a University environment How to apply Before submitting an application, you may find it helpful to read the ‘Tips on applying for a job at the University of Oxford’ document, at http://www.ox.ac.uk/about_the_university/jobs/professionalandmanagement/ If you would like to apply, click on the Apply Now button on the ‘Job Details’ page and follow the on-screen instructions to register as a new user or log-in if you have applied previously. Please provide details of three referees and indicate whether we can contact them now. You will also be asked to upload a CV and a supporting statement. The supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. This may include experience gained in employment, education, or during career breaks (such as time out to care for dependants). Your application will be judged solely on the basis of how you demonstrate that you meet the selection criteria stated in the job description. Please note that if you do not upload a supporting statement, we will be unable to consider your application. Please upload all documents as PDF files with your name and the document type in the filename. All applications must be received by midday on the closing date stated in the online advertisement. 5 Information for priority candidates A priority candidate is a University employee who is seeking redeployment because they have been advised that they are at risk of redundancy, or on grounds of ill-health/disability. Priority candidates are issued with a redeployment letter by their employing departments. If you are a priority candidate, please ensure that you attach your redeployment letter to your application (or email it to the contact address on the advert if the application form used for the vacancy does not allow attachments) Should you experience any difficulties using the online application system, please email recruitment.support@admin.ox.ac.uk. Further help and support is available from www.ox.ac.uk/about_the_university/jobs/support/. To return to the online application at any stage, please go to: www.recruit.ox.ac.uk. Please note that you will be notified of the progress of your application by automatic emails from our e-recruitment system. Please check your spam/junk mail regularly to ensure that you receive all emails. Important information for candidates Data Privacy Please note that any personal data submitted to the University as part of the job application process will be processed in accordance with the GDPR and related UK data protection legislation. For further information, please see the University’s Privacy Notice for Job Applicants at: www.admin.ox.ac.uk/councilsec/compliance/gdpr/privacynotices/job/. The University’s Policy on Data Protection is available at: www.admin.ox.ac.uk/councilsec/compliance/gdpr/ universitypolicyondataprotection/. The University’s policy on retirement The University operates an Employer Justified Retirement Age (EJRA) for all academic posts and some academic-related posts. From 1 October 2017, the University has adopted an EJRA of 30 September before the 69th birthday for all academic and academic-related staff in posts at grade 8 and above. The justification for this is explained at: www.admin.ox.ac.uk/personnel/ end/retirement/acrelretire8+/. For existing employees, any employment beyond the retirement age is subject to approval through the procedures: www.admin.ox.ac.uk/personnel/end/retirement/acrelretire8+/. From 1 October 2017, there is no normal or fixed age at which staff in posts at grades 1–7 have to retire. Staff at these grades may elect to retire in accordance with the rules of the applicable pension scheme, as may be amended from time to time. Equality of Opportunity Entry into employment with the University and progression within employment will be determined only by personal merit and the application of criteria which are related to the duties of each particular post and the relevant salary structure. In all cases, ability to perform the job 6 will be the primary consideration. No applicant or member of staff shall be discriminated against because of age, disability, gender reassignment, marriage or civil partnership, pregnancy or maternity, race, religion or belief, sex, or sexual orientation. About the University of Oxford Welcome to the University of Oxford. We aim to lead the world in research and education for the benefit of society both in the UK and globally. Oxford’s researchers engage with academic, commercial and cultural partners across the world to stimulate high-quality research and enable innovation through a broad range of social, policy and economic impacts. We believe our strengths lie both in empowering individuals and teams to address fundamental questions of global significance, while providing all our staff with a welcoming and inclusive workplace that enables everyone to develop and do their best work. Recognising that diversity is our strength, vital for innovation and creativity, we aspire to build a truly diverse community which values and respects every individual’s unique contribution. While we have long traditions of scholarship, we are also forward-looking, creative and cuttingedge. Oxford is one of Europe's most entrepreneurial universities. Income from external research contracts in 2016/17 exceeded £564m and we rank first in the UK for university spinouts, with more than 130 companies created to date. We are also recognised as leaders in support for social enterprise. Join us and you will find a unique, democratic and international community, a great range of staff benefits and access to a vibrant array of cultural activities in the beautiful city of Oxford. For more information please visit www.ox.ac.uk/about/organisation Nuffield Department of Women’s & Reproductive Health (NDWRH) The Nuffield Department of Women’s & Reproductive Health (NDWRH) is one of the largest and most successful academic departments in the world in its field. There are approximately 160 people working in the department, including senior academic staff, research support staff, clerical and technical staff, and graduate students (including clinicians) carrying out research towards a higher degree. There are also a number of visiting researchers from many parts of the world. The average annual income is approximately £10 million, of which over 75% comes from outside sources. NDWRH encompasses multi-disciplinary research across the full spectrum of women’s health. Our work has four overarching themes; Cancer, Global Health, Maternal & Fetal Health and Reproductive Medicine & Genetics. We focus on genetic studies, the dissection of molecular, biochemical and cellular mechanisms underlying normal and aberrant reproductive tissue function, and clinical studies in women’s health, assisted reproduction and pregnancy, as well as growth and development across the first 1000 days of life. The department also now includes The George Institute for Global Health, whose mission is to increase access to quality health care for millions of people worldwide - with a particular focus on vulnerable women in resource-poor settings. The clinical and laboratory programmes are based in the Women’s Centre, John Radcliffe Hospital; Weatherall Institute of Molecular Medicine; Winchester House, and the Big Data 7 Institute, and there are collaborations with the School’s Institutes, the University’s Science Departments and with researchers outside Oxford, in both the UK and abroad, especially in lowmiddle income countries. For more information please visit: www.wrh.ox.ac.uk The University of Oxford is a member of the Athena SWAN Charter and holds an institutional Bronze Athena SWAN award. NDWRH holds a departmental Silver Athena award in recognition of its efforts to introduce organisational and cultural practices that promote gender equality in SET and create a better working environment for both men and women. 8 Benefits of working at the University Employee benefits University employees enjoy 38 days’ paid holiday, generous pension schemes, travel discounts, and a variety of professional development opportunities. Our range of other employee benefits and discounts also includes free entry to the Botanic Gardens and University colleges, and discounts at University museums. See www.admin.ox.ac.uk/personnel/staffinfo/benefits. University Club and sports facilities Membership of the University Club is free for all University staff. The University Club offers social, sporting, and hospitality facilities. Staff can also use the University Sports Centre on Iffley Road at discounted rates, including a fitness centre, powerlifting room, and swimming pool. See www.club.ox.ac.uk and www.sport.ox.ac.uk/oxford-university-sports-facilities. Information for staff new to Oxford If you are relocating to Oxfordshire from overseas or elsewhere in the UK, the University's Welcome Service website includes practical information about settling in the area, including advice on relocation, accommodation, and local schools. See www.welcome.ox.ac.uk. There is also a visa loan scheme to cover the costs of UK visa applications for staff and their dependents. See www.admin.ox.ac.uk/personnel/permits/reimburse&loanscheme/. Family-friendly benefits With one of the most generous family leave schemes in the Higher Education sector, and a range of flexible working options, Oxford aims to be a family-friendly employer. We also subscribe to My Family Care, a service that provides practical advice and support for employees who have caring responsibilities. The service offers a free telephone advice line, and the ability to book emergency back-up care for children, adult dependents and elderly relatives. See www.admin.ox.ac.uk/personnel/staffinfo/benefits/family/mfc/. Childcare The University has excellent childcare services, including five University nurseries as well as University-supported places at many other private nurseries. For full details, including how to apply and the costs, see www.admin.ox.ac.uk/childcare/. Disabled staff We are committed to supporting members of staff with disabilities or long-term health conditions. For further details, including information about how to make contact, in confidence, with the University’s Staff Disability Advisor, see www.admin.ox.ac.uk/eop/disab/staff. Staff networks The University has a number of staff networks including the Oxford Research Staff Society, BME staff network, LGBT+ staff network and a disabled staff network. You can find more information at www.admin.ox.ac.uk/eop/inpractice/networks/. The University of Oxford Newcomers' Club The University of Oxford Newcomers' Club is an organisation run by volunteers that aims to assist the partners of new staff settle into Oxford, and provides them with an opportunity to meet people and make connections in the local area. See www.newcomers.ox.ac.uk. 9 """^^ . "Voice"@en . _:Nfd19c71f6b794ad98e604feb3a90b11b "United Kingdom" . . "account" . "legal page"@en . 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