Postdoctoral Researcher in Neuroimmunology
Applications for this vacancy closed on 23 October 2023 at 12:00PM
We are looking for a **Postdoctoral Researcher in Neuroimmunology** to join
the Oxford Autoimmune Neurology Group (OANG), within the Nuffield Department
of Clinical Neurosciences (NDCN).
The OANG have described the clinical and immunological features of patients
with autoantibody-mediated diseases of the central nervous system (CNS).
Often, these patients show highly distinctive clinical characteristics that
closely associate with antigen-specific autoantibodies, including those
binding to NMDA receptors, LGI1 and glutamic acid decarboxylase (GAD) amongst
other antigenic targets.
In many cases, it is clear that the autoantibodies are directly pathogenic.
However, there is emerging evidence that T cells and other non-B cell
components of the immune system are important in the immunopathogenesis of
these conditions. For example, LGI1 antibody encephalitis has one of the
strongest MHC associations in human disease. Neuropathology studies have
demonstrated a key role for T cells in neuronal damage in GAD antibody-
associated CNS disorders.
You will be reporting to Dr Adam Handel, who runs a national referral clinic
for patients with autoimmune encephalitis. As part of this clinic, patients
frequently contribute to research through the donation of multiple different
types of samples, including blood, cerebrospinal fluid and lymph node
aspirates.
The post-holder will investigate the dynamic role of T cells in several
different autoantibody-associated CNS disorders through the integration of
functional and single cell sequencing data across multiple disease-relevant
compartment.
Dr Handel has recently been awarded an MRC New Investigator Award for 3 years
to investigate T cells in autoimmune encephalitis. OANG has been very
successful in attracting excellent scientists and clinical academics, and so
there would be ample opportunities for the post-holder to contribute to many
other projects as well as leading his/her own project within the group.
The successful candidate will hold a PhD / DPhil in a relevant scientific
subject (the qualification can be held or submitted for examination/nearing
completion by the time of starting the post) as well as be able to show
demonstrable experience in immunology or autoimmune disease. They will also
have expertise in cellular or molecular biology, experience with research and
the ability to apply statistical methods to address biological questions.
Experience on T cell functional or antigen specific assays is desirable.
Please see the below 'Job Description' for further details on the
responsibilities and selection criteria, as well as further information about
the university and how to apply.
**This post is full time and fixed term for 2 years.**
**Only applications received before 12pm midday on 23rd October 2023 will be
considered.**
**Interviews will be held as soon as possible thereafter.**
the Oxford Autoimmune Neurology Group (OANG), within the Nuffield Department
of Clinical Neurosciences (NDCN).
The OANG have described the clinical and immunological features of patients
with autoantibody-mediated diseases of the central nervous system (CNS).
Often, these patients show highly distinctive clinical characteristics that
closely associate with antigen-specific autoantibodies, including those
binding to NMDA receptors, LGI1 and glutamic acid decarboxylase (GAD) amongst
other antigenic targets.
In many cases, it is clear that the autoantibodies are directly pathogenic.
However, there is emerging evidence that T cells and other non-B cell
components of the immune system are important in the immunopathogenesis of
these conditions. For example, LGI1 antibody encephalitis has one of the
strongest MHC associations in human disease. Neuropathology studies have
demonstrated a key role for T cells in neuronal damage in GAD antibody-
associated CNS disorders.
You will be reporting to Dr Adam Handel, who runs a national referral clinic
for patients with autoimmune encephalitis. As part of this clinic, patients
frequently contribute to research through the donation of multiple different
types of samples, including blood, cerebrospinal fluid and lymph node
aspirates.
The post-holder will investigate the dynamic role of T cells in several
different autoantibody-associated CNS disorders through the integration of
functional and single cell sequencing data across multiple disease-relevant
compartment.
Dr Handel has recently been awarded an MRC New Investigator Award for 3 years
to investigate T cells in autoimmune encephalitis. OANG has been very
successful in attracting excellent scientists and clinical academics, and so
there would be ample opportunities for the post-holder to contribute to many
other projects as well as leading his/her own project within the group.
The successful candidate will hold a PhD / DPhil in a relevant scientific
subject (the qualification can be held or submitted for examination/nearing
completion by the time of starting the post) as well as be able to show
demonstrable experience in immunology or autoimmune disease. They will also
have expertise in cellular or molecular biology, experience with research and
the ability to apply statistical methods to address biological questions.
Experience on T cell functional or antigen specific assays is desirable.
Please see the below 'Job Description' for further details on the
responsibilities and selection criteria, as well as further information about
the university and how to apply.
**This post is full time and fixed term for 2 years.**
**Only applications received before 12pm midday on 23rd October 2023 will be
considered.**
**Interviews will be held as soon as possible thereafter.**
| dc:spatial |
Nuffield Department of Clinical Neurosciences (NDCN), John Radcliffe Hospital, Oxford, OX3 9DU
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| oo:contact | |
| oo:formalOrganization | |
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| vacancy:applicationClosingDate |
2023-10-23 12:00:00+01:00
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| vacancy:applicationOpeningDate |
2023-08-08 09:00:00+01:00
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| vacancy:furtherParticulars | |
| vacancy:internalApplicationsOnly |
False
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| vacancy:salary | |
| type | |
| comment |
We are looking for a Postdoctoral Researcher in Neuroimmunology to join the Oxford Autoimmune Neurology Group (OANG), within the Nuffield Department of Clinical Neurosciences (NDCN). The OANG have described the clinical and immunological features of patients with autoantibody-mediated diseases of the central nervous system (CNS). Often, these patients show highly distinctive clinical characteristics that closely associate with antigen-specific autoantibodies, including those binding to NMDA receptors, LGI1 and glutamic acid decarboxylase (GAD) amongst other antigenic targets. In many cases, it is clear that the autoantibodies are directly pathogenic. However, there is emerging evidence that T cells and other non-B cell ... We are looking for a **Postdoctoral Researcher in Neuroimmunology** to join
the Oxford Autoimmune Neurology Group (OANG), within the Nuffield Department of Clinical Neurosciences (NDCN). The OANG have described the clinical and immunological features of patients with autoantibody-mediated diseases of the central nervous system (CNS). Often, these patients show highly distinctive clinical characteristics that closely associate with antigen-specific autoantibodies, including those binding to NMDA receptors, LGI1 and glutamic acid decarboxylase (GAD) amongst other antigenic targets. In many cases, it is clear that the autoantibodies are directly pathogenic. However, there is emerging evidence that T cells and other non-B cell components ... |
| label |
Postdoctoral Researcher in Neuroimmunology
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| notation |
167235
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