Laboratory Technician in Next Generation Sequencing of Musculoskeletal Tissues

There is an exciting opportunity for a Laboratory Technician in Next
Generation Sequencing of Musculoskeletal Tissues in the Nuffield Department of
Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS) based at the
Botnar Research Centre, Oxford. We seek an experienced and enthusiastic
individual to join the Cribbs and Snelling labs and work within the UK
Research and Innovation Musculoskeletal Functional Genomics Cluster. Your work
will help to accelerate translation of genetic findings to treat four key
musculoskeletal diseases: osteoarthritis, carpal tunnel syndrome, frozen
shoulder, and Dupuytren disease.



As a Laboratory Technician in our group, you will be responsible for the
development/implementation of standardized protocols for patient blood and
tissue sample processing prior to nucleic acid extraction or imaging. You will
employ a combination of molecular biology techniques including RNA and DNA
extraction, and will assist with library preparation for NGS and with
multiplex imaging of samples. You will liaise with clinical and research nurse
teams (to ensure collection of suitable patient samples) and other members of
the research group (regarding experimental techniques and general lab
procedures). You will also teach experimental techniques to new laboratory and
cluster members, and contribute to wider project discussions/planning, sharing
research findings with colleagues in partner institutions and research groups.
In addition, you will have some reporting, data management, and lab
maintenance responsibilities.



You will hold an MSc or BSc in biological science (or equivalent experience).
Previous lab experience (cell culture, DNA/RNA isolation), excellent
organisational skills (especially the ability to keep detailed, HTA and GDPR
legislation compliant records of samples and results), and the ability to work
flexibly and cooperatively both as part of a team and independently are
essential. Previous experience in a university environment and with techniques
such as NGS library preparation and multiplex imaging are desirable but not
essential.



This is a full-time (part-time 60% to 80% FTE will be considered), fixed-term
appointment for 24 months.



The closing date for this position is 12 noon on 24 May 2024. You will be
required to upload a CV and supporting statement as part of your online
application.