All vacancies within Department of Paediatrics

There are currently 3 vacancies within Department of Paediatrics:

Title	Closes	Salary
Paediatric Research Assistant	May 13, 2019, noon	Grade 6, £28,660 - £34,189 p.a.
Laboratory Research Assistant	May 16, 2019, noon	Grade 5: £25,482 - £30,395 p.a.
Laborartory Research Assistant (maternity cover)	May 23, 2019, noon	Grade 5: £25,482 - £30,395 p.a.

Paediatric Research Assistant

Closes: May 13, 2019, noon; salary: Grade 6, £28,660 - £34,189 p.a.

<div> Professor Matthew Woods laboratory the pioneer in engineering extracellular vesicles (EVs) for delivering siRNA-based drugs to the brain is looking for a highly motivated Research Assistant to join our Neuromuscular Disease group at Department of Paediatrics, University of Oxford. The successful candidate will work on a Medical and Life Science Translational Funded project, GAPDH and Extracellular vesicles: Biological nanoparticles for therapy of neurodegenerative diseases. The project involves optimisation of novel technology developed recently in the lab for delivering RNA drugs to central nervous system of Huntingtons disease mouse model to silence mutant huntingtin gene. We are also investigating biogenesis of extracellular vesicles (EV) with major focus on role of GAPDH protein in secretion of EVs. As a member of the Wood Group, you will work with a postdoctoral research scientist for day-to-day planning and execution of experiments such as engineering of EVs using molecular biology approach, purification of the EV-binding proteins from E. coli cells and presenting data at scientific meeting. Your responsibilities will include the establishment of stable cell lines for various EV protein markers by using lentiviral vectors, and isolation of EVs from different eukaryotic cell lines using our state of the art technology of EV purification by ultrafiltration and liquid chromatography. You will carry out collaborative projects with lab colleagues and partners at Cambridge and collaborate in the preparation of scientific reports and journal articles, and the presentation of papers and posters at conferences. The ideal candidate will have an MSc in a relevant area of research such as cell biology, exosome biology, nanotechnology, gene transfer or molecular medicine; and will have experience in cellular transfections, confocal microscopy, flow cytometry and RNA and protein extraction for subsequent exosome characterisation by western blot and RT-qPCR. They will be able to communicate effectively with others, have an ability to work both independently and as part of a team, and have excellent organisational skills and the ability to keep meticulous records. This is a full-time post offered for a fixed-term of 12 months in the first instance. Only applications received before 12.00 noon on Monday 13 May 2019 will be considered. Interviews will be held as soon as possible thereafter. </div>

Laboratory Research Assistant

Closes: May 16, 2019, noon; salary: Grade 5: £25,482 - £30,395 p.a.

<div> Applications are invited for the post of Laboratory Research Assistant to the Oxford Vaccine Group, part of the Department of Paediatrics in the Medical Scieneces Division. The Oxford Vaccine Group Laboratory, under the direction of Professor Pollard is staffed by 23 research staff including technical, undergraduate, graduate and postdoctoral scientists. The job requires flexibility in working hours, including potentially some weekend work. Research projects include: evaluation of immune responses to vaccines in children and adults; understanding of the nature of immunological memory; development of a novel vaccines and pre-clinical studies; genetics of the immune response to vaccines; natural and vaccine-induced immunity to Salmonella Typhi; invasive bacterial infections in South Asia. The successful candidate will be working in containment level 2 and containment level 3 laboratories for the receipt, tracking, storage/archiving of study related samples such as serum, peripheral blood mononuclear cells, urine, saliva, and stool specimens. You will conduct all laboratory work to the standards expected from Good Laboratory Practice and OVG quality management guidelines which will include compliance with Human Tissue Authority (HTA) and Medicines and Healthcare products Regulatory Agency (MHRA) regulations. The successful candidate will have practical laboratory/clinical laboratory experience and will be able to work as a member of a team. Only applications received by 12.00 noon on 16 May 2019 will be considered. </div>

Laborartory Research Assistant (maternity cover)

Closes: May 23, 2019, noon; salary: Grade 5: £25,482 - £30,395 p.a.

<div> Applications are invited for a position of Laboratory Research Assistant as a maternity cover. The Oxford Vaccine Group Laboratory, under the direction of Professor Pollard is staffed by 23 research staff including technical, undergraduate, graduate and postdoctoral scientists. The job requires flexibility in working hours, including potentially some weekend work. Research projects include: evaluation of immune responses to vaccines in children and adults; understanding of the nature of immunological memory; development of a novel vaccines and pre-clinical studies; genetics of the immune response to vaccines; natural and vaccine-induced immunity to Salmonella Typhi; invasive bacterial infections in South Asia. Your duties will include working in Containment level 2 and Containment level 3 laboratories for the receipt, tracking, storage/archiving of study related samples such as serum, peripheral blood mononuclear cells, urine, saliva, and stool specimens. You will also conduct all laboratory work to the standards expected from Good Laboratory Practice and OVG quality management guidelines which will include compliance with Human Tissue Authority (HTA) and Medicines and Healthcare products Regulatory Agency (MHRA) regulations. The successful candidate will have practical laboratory/clinical laboratory experience and will be able to work as a member of a team. Applications need to be received by 12.00 noon on 23 May 2019 to be considered. </div>