All vacancies within Radcliffe Department of Medicine

There are currently 12 vacancies within Radcliffe Department of Medicine:

Title	Closes	Salary
Computational Biologist in Single Cell Genomics	Feb. 19, 2019, noon	Grade 8: £40,792 - £48,677 p.a.
Postdoctoral Research Assistant - Haemopoietic Stem Cell and Niche Biology	Feb. 20, 2019, noon	Grade 7: £32,236 - £39,609 p.a.
Research Assistant in Acute Myeloid Leukaemia/Genetics	Feb. 20, 2019, noon	Grade 6: £28,660 - £34,189 p.a.
Laboratory Manager/Biobank Support Co-ordinator	Feb. 21, 2019, noon	Grade 7: £32,236 - £39,609 p.a.
Postdoctoral Researcher in Medicine (Computational Biology)	Feb. 22, 2019, noon	Grade 8: £40,792 - £48,677 p.a.
Postdoctoral Scientist in Structural and Stem Cell Biology	March 1, 2019, noon	Grade 7: £32,236 - £39,609 p.a.
Postdoctoral Research Assistant	March 4, 2019, noon	Grade 7: £32,236 - £39,609 p.a.
Postdoctoral Researcher in Innate Immunity in Inherited Cardiomyopathy	March 4, 2019, noon	Grade 7: £32,236 - £36,261 p.a
Research Assistant in Blood Stem Cell Development	March 8, 2019, noon	Grade 6: £28,660 - £34,189 p.a.
Research Nurse	March 11, 2019, noon	Grade 6: £28,660 - £34,189 p.a.
Novo Nordisk Clinical Research Training Fellow in Diabetes and Metabolism	March 22, 2019, noon	Grade E64: £32,569 £52,200 p.a.
Novo Nordisk Postdoctoral Research Fellow in Diabetes and Metabolism (4 posts)	March 22, 2019, noon	Grade 7: £32,236 - £39,609 p.a.

Computational Biologist in Single Cell Genomics

Closes: Feb. 19, 2019, noon; salary: Grade 8: £40,792 - £48,677 p.a.

<div> Applications are invited for an experienced and highly motivated individual to lead the analysis of single cell gene expression profiling data investigating transcriptional changes in response to brain state, as part of a 5 year Wellcome Trust Collaborative award. The successful candidate will lead the analysis of single cell RNAseq profiles from thousands of neurons, representing the entire fly midbrain, from flies in different brain states. They will work closely with experimental collaborators within the Centre for Neural Circuits and Behaviour to answer important questions in neuroscience; investigating how the transcriptomes of individual cells change in response to learning and internal states, and to understand how sex-specific neuronal identity emerge from transcriptional programmes. You will hold a PhD in a quantitative discipline (e.g. bioinformatics, computational biology, physics, statistics, engineering or mathematics). You will be have expereince of working in a Linux environment and be proficient in Python and R. Excellent interpersonal and communication skills, with the ability to convey concepts to other scientists in different fields of research are essential. Experience in computational genomics is highly desirable. The position is available fixed-term for 5 years from 1 April 2019, funded by the Wellcome Trust. Applications for this vacancy are to be made online. You will be required to upload a CV and supporting statement as part of your online application. Consideration will be given to applicants who do not fulfil all of the criteria for a Grade 8 appointment. A reduction in duties and criteria for a Grade 7 appointment (£32,236 - £39,609 p.a.) are detailed in the job description. The closing date for this position is 12.00 noon on Friday 22 February 2019. </div>

Postdoctoral Research Assistant - Haemopoietic Stem Cell and Niche Biology

Closes: Feb. 20, 2019, noon; salary: Grade 7: £32,236 - £39,609 p.a.

<div> We are seeking a talented, motivated high-calibre Postdoctoral Research Assistant to join Professor Paresh Vyass laboratory (www.imm.ox.ac.uk/research/units-and-centres/mrc-molecular-haematology-unit/research-groups/vyas-group-normal-and-malignant-haematopoiesis-lab). This position will focus on purification of human haemopoietic stem cells, defining the cells that comprise the bone marrow niche, and to begin dissection of the two-directional signalling between these two cells populations. Working as an individual and as part of a team, you will study flow-sorted normal human marrow samples and extensively study single cell populations. You will use state-of-the-art methods to characterise the molecular properties of these cells and function in vitro and in vivo (using gene editing approaches to generate novel humanised models). You will present to journal clubs and laboratory meetings. This position will allow you become expert in haemopoietic stem cell biology, niche biology and use of gene editing to develop new tools to study stem cell function. You will have a PhD in a relevant discipline with a strong publication record in peer-reviewed journals. Previous experience in molecular biology techniques such as CRISPR/Cas-9 mediated gene editing, Next Generation Sequencing, culturing primary cells (ideally haemopoietic cells) and working with in vivo murine models are essential. You will have the ability to work both as a team member and independently, with excellent organisational and communication skills. The post is available fixed-term until 31 March 2021, funded by NIHR Oxford Biomedical Research Centre. Applications for this vacancy are to be made online. You will be required to upload a CV and supporting statement as part of your online application. The closing date for this position is 12.00 noon on 20 February 2019. Interviews will be held in early March 2019. </div>

Research Assistant in Acute Myeloid Leukaemia/Genetics

Closes: Feb. 20, 2019, noon; salary: Grade 6: £28,660 - £34,189 p.a.

<div> We are seeking a motivated and enthusiastic Research Assistant to join the research group of Professor Paresh Vyas (www.imm.ox.ac.uk/research/units-and-centres/mrc-molecular-haematology-unit/research-groups/vyas-group-normal-and-malignant-haematopoiesis-lab). The groups research interests focus on understanding how genetic and epigenetic changes disturb normal stem and progenitor haemopoietic differentiation to lead to clonal haemopoiesis myelodysplasia (a pre-leukaemic disorder) and acute myeloid leukaemia (the most common aggressive adult leukaemia). Allied to this the laboratory conducts translational research to improve existing treatment and develop novel therapies for these devastating diseases. Working as part of a team, you will study patient samples to define genetic (next generation sequencing) and epigenetic (ATAC-Seq and ChiP-Seq) changes in flow sorted leukaemic populations. You will study measurable residual disease in patient samples from clinical trials. You will hold a degree minimum 2:1 in biology, genetics, biochemistry or a biomedically-related area and have proven experience in molecular and cellular biology methods, next generation sequencing and FACS analysis. Experience of coding and bioinformatic analysis is desirable. The ability to work both as part of a team and independently, a methodical approach to laboratory work with good manual dexterity and excellent organisational and communication skills are essential. The post is fixed-term, funded by the NIHR Oxford Biomedical Research Centre until 31 March 2021, with an immediate start. Applications for this vacancy are to be made online. You will be required to upload a CV and supporting statement as part of your online application The closing date for this position is 12.00 noon on 20 February 2019. Interviews will be held in early March 2019. </div>

Laboratory Manager/Biobank Support Co-ordinator

Closes: Feb. 21, 2019, noon; salary: Grade 7: £32,236 - £39,609 p.a.

<div> THIS VACANCY IS FOR INTERNAL APPLICANTS ONLY We are seeking a highly organised, motivated and enthusiastic Laboratory Manager/Biobank Support Co-ordinator. The role is busy and varied, divided between laboratory management responsibilities, providing support and co-ordination for the Biobank Facility and research project support. You will take primary responsibility for laboratory management including maintaining the supply of consumables and ensuring equipment is functioning, as well as day-to-day oversight and training of tissue bank staff. The role will also involve ensuring that health and safety returns are made and that goods are purchased appropriately in accordance with University regulations, grants and sponsors. You will be expected to conduct basic molecular and cellular biology experiments and perform flow cytometric analysis and sorting. You will have a degree in biological sciences with a strong background in cellular and molecular biology. Previous experience in laboratory/biobank management in a scientific or biomedical environment and the induction of training and supervision of new staff is essential. You will have experience of writing and maintaining SOPs and laboratory protocols and working to GLP standards. Experience in FACS sorting and working with primary haemopoietic cells is desirable. The post if available fixed-term until 31 March 2022, funded by the Oxford Biomedical Research Centre (BRC). Applications for this vacancy are to be made online. You will be required to upload a CV and supporting statement as part of your online application. The closing date for this position is 12.00 noon on Thursday 21 February 2019. </div>

Postdoctoral Researcher in Medicine (Computational Biology)

Closes: Feb. 22, 2019, noon; salary: Grade 8: £40,792 - £48,677 p.a.

<div> We wish to hire a talented and highly motivated Postdoctoral Researcher in Medicine (Computational Biology) to investigate the translational implications of mechanisms underlying human tissue T cell immune responses. Graham Oggs group is studying lipid-specific and peptide-specific T cells in the blood and skin in order to define disease pathogenesis and to identify targets for future therapeutic intervention. You will work jointly with Hashem Koohys group, specialised in machine-learning and computational biology and Graham Oggs group specialised in skin immunology. You will conduct research in a dynamic and highly collaborative environment of an internationally leading research institute. You will benefit from the institute and wider university expertise in immunology, computational biology, machine-learning and big-data science. There will be opportunities to develop new models to explain differential responses of T cell populations during homeostasis, inflammation and cancer. To be considered for this position you should hold a PhD in a relevant subject and have experience in at least one of the following; bioinformatics, machine-learning, statistics or data science. You should have excellent programming skills in at least one programming language preferably python or R. The post is fixed-term for 3 years. Applications for this vacancy are to be made online. You will be required to upload a supporting statement and CV as part of your online application. Only applications received before 12.00 noon on Friday 22 February 2019 will be considered. </div>

Postdoctoral Scientist in Structural and Stem Cell Biology

Closes: March 1, 2019, noon; salary: Grade 7: £32,236 - £39,609 p.a.

<div> THIS IS A RE-ADVERTISEMENT. PREVIOUS APPLICANTS NEED NOT APPLY This is a unique opportunity for a driven, highly motivated and talented Postdoctoral Scientist to join the research group of Professor Catherine Porcher to characterise and solve the structure of a multiprotein complex involved in the transcriptional regulation of blood stem cell development in normal and malignant conditions. This exciting project, at the forefront of its field, is a collaboration with Dr Denis Ptchelkine leading structural biology research at the MRC Weatherall Institute of Molecular Medicine. It will employ molecular, biochemical, biophysical and cryo-EM studies. Key residues involved in protein/protein and protein/DNA interactions will be identified and functionally analysed. This high impact study will provide essential details for a mechanistic understanding of the transcriptional activities of this blood stem cell-specific complex. The position is available fixed-term for 24 months, funded by the Medical Research Council (MRC). You will hold a PhD (or near to completion: thesis submitted) in a relevant area, with experience in molecular biology, cloning strategies, tissue culture, protein expression and purification and biochemical and biophysical assays. You will have excellent communication and organisational skills, with the ability to work as part of a team as well as to manage and independently drive your own research. Previous experience in cryo-EM is desirable. Applications for this vacancy are to be made online. You will be required to upload a CV and supporting statement as part of your online application. The closing date for this position is 12.00 noon on Friday 1 March 2019. </div>

Postdoctoral Research Assistant

Closes: March 4, 2019, noon; salary: Grade 7: £32,236 - £39,609 p.a.

<div> An exciting opportunity has arisen for a Postdoctoral Research Assistant position in the David Ray group within OCDEM on a highly prestigious MRC funded programme of research. This programme builds on recent discoveries from our group, which have identified the importance of biological timing mechanisms in the resolution of inflammation, and the development of co-morbidities in chronic inflammatory disease. We are now building an interdisciplinary team of exceptional early career scientists to move forward in this field, and make the next major discoveries. You will join a well-resourced team with a track record of major discoveries, and moving fellows into permanent academic positions. We have unique and innovative models, both in-vivo and in-vitro, which allow entirely new biological insights into circadian control of inflammation, and energy metabolism. The deep phenotyping of these models, with high throughput omics technology platforms, cell based assays and systems microscopy permits rapid advances to be made, with new insights, high-impact publications, and potential therapeutic advances. We build on unique strengths coupling circadian biology and metabolic science, and will use CRISPR, and genetic engineering approaches to investigate novel pathways regulating liver phenotype, and metabolic flux. We can couple this genetic approach to chemical biology interventions, such as those we have recently pioneered to target circadian clock components. Outputs: There is an expectation that the candidate will publish in high-impact journals, present at international meetings, drive project progression, and capitalise on the joint academic stakeholders at the Universities of Oxford, and Manchester. There is considerable scope to pursue exciting new biological pathways emerging from the discovery platforms. You will have an interest in or experience of inflammation biology, energy metabolism, and circadian biology. Some experience of in-vivo physiology is desirable. A relevant PHD is essential, the postholder will also be expected to have familiarity with statistical methods, previous publications and experience of presentations. The postholder will generate and analyse novel, cell type targeted transgenic mice. The post will also develop and apply in-vivo models of chronic joint inflammation, they will also be expected to present work at national meetings. The position is full-time and fixed-term for 3 years in the first instance with the possibility for extension. The position will be based at OCDEM, Churchill Hospital, Oxford. The post is funded by the MRC. Please quote reference 139171 on all correspondence. You will be required to upload a CV and supporting statement as part of your online application. Only applications received before 12.00 midday on 4 March 2019 can be considered. Interviews are scheduled for the morning of 15 March 2019. </div>

Postdoctoral Researcher in Innate Immunity in Inherited Cardiomyopathy

Closes: March 4, 2019, noon; salary: Grade 7: £32,236 - £36,261 p.a

<div> We are looking for a well-trained, highly motivated and academically excellent Research Assistant to join our research team and become a member of the Inherited Heart Muscle Disease Group led by Professor Hugh Watkins FRS FMedSci. A significant focus for the post is to investigate the role of the innate immune system in cardiac tissue remodelling in response to dysfunctional cardiomyocytes carrying myofilament mutation(s) using the HCM mouse models. The work will employ the cutting edge single cell genomic approaches, well-established in vivo mouse models, advanced immunological and imaging techniques (e.g. FACSymphony, cell sorting, CyTOF, two-photon confocal fluorescence microscopy, and light sheet microscopy), leading to the identification of new targets for therapy for families with cardiomyopathy. You will hold a PhD degree in immunology, molecular and cell biology or similar and have the capacity to deliver high quality research outputs, as illustrated by a strong publication record in high profile immunological journals. Proven experience in macrophage biology is desirable. This full-time appointment is on a fixed-term until 9 September 2023 and you will work under the supervision of Professor Houman Ashrafian, Professor Charles Redwood and Professor Hugh Watkins in the Division of Cardiovascular Medicine in collaboration with Professor Vincenzo Cerundolo at the MRC Human Immunology Unit at the Weatherall Institute of Molecular Medicine. You will be based at the Wellcome Centre for Human Genetics, Roosevelt Drive Oxford. Applications for this vacancy are to be made online; you will be required to upload a CV and supporting statement which explains how you meet the selection criteria for the post. Only applications received before 12.00 midday on 1 March 2019 can be considered. Interviews are scheduled to place on 15 March 2019. </div>

Research Assistant in Blood Stem Cell Development

Closes: March 8, 2019, noon; salary: Grade 6: £28,660 - £34,189 p.a.

<div> We are seeking a motivated and enthusiastic Research Assistant to join the research group of Dr Marella de Bruijn. The research group is interested in how blood and immune cells are generated in mammalian development. The successful applicant will be responsible for carrying out experiments designed to advance specific semi-independent projects using a range of different techniques. You will have a degree in biological sciences and a period of relevant practical working experience within a laboratory. Strong organisational skills, experience in mouse husbandry, and experience in core techniques including molecular biology, imaging, cell culture, flow cytometry, and basic bioinformatics are essential to the post. A demonstrable interest in developmental haematopoiesis is desirable. The post is available immediately, fixed-term until 31 March 2022, funded by the Medical Research Council. Applications for this vacancy are to be made online. You will be required to upload a CV and supporting statement as part of your online application. The closing date for this position is 12.00 noon on Friday 8 March 2019. </div>

Research Nurse

Closes: March 11, 2019, noon; salary: Grade 6: £28,660 - £34,189 p.a.

<div> We are looking for an enthusiastic and motivated research nurse with an interest in heart failure to be involved with an exciting study into dilated cardiomyopathy (DCM). You will lead the GO-DCM study in collaboration with the Principle Investigator for the Oxford University site. Your role will include the identification of potential participants for study enrolment, coordination of study visits, informed consent, accurate clinical data collection and management, sample collection, safe/accurate sample processing and timely follow-up You will work collaboratively within the multidisciplinary study team to ensure the effective delivery of a high standard of nursing care for all study participants/clinical patients within the department of OCMR and the Division of Cardiovascular Medicine. You will need to be a registered nurse: entry on part 1 (adult) of the NMC register. (PIN number and entry date, plus revalidation date to be stated within application). You will also need to be educated to degree level or equivalent experience. Evidence of training and competency in venepuncture and cannulation would be desirable. This is a full-time appointment based at the University of Oxford Centre for Clinical Magnetic Resonance Research (OCMR), John Radcliffe Hospital, Oxford. This post is available immediately for 3 years. Applications for this vacancy are to be made online; you will be required to upload a CV and supporting statement which explains how you meet the selection criteria for the post. Only applications received before 12.00 midday on 11 March 2019 can be considered. Interviews are scheduled to take the week commencing 25 March 2019 </div>

Novo Nordisk Clinical Research Training Fellow in Diabetes and Metabolism

Closes: March 22, 2019, noon; salary: Grade E64: £32,569 £52,200 p.a.

<div> Novo Nordisk is funding a prestigious fellowship programme at the University of Oxford for both basic science and clinical researchers, focused on diabetes research. We are looking to recruit an outstanding Clinical Research Training Fellow who can utilise the support offered by this programme to become a future leader in the field, developing scientific excellence within diabetes and ultimately improving patients lives. In Oxford, world-class diabetes research is conducted across the spectrum of population, clinical and basic science. Depending on the project selected, you will be based in: 1) Oxford Centre for Diabetes, Endocrinology and Metabolism, 2) Division of Cardiovascular Medicine, 3) Department of Physiology, Anatomy and Genetics, 4) Nuffield Department of Medicine or, 5) The Kennedy Institute of Rheumatology. There is also the opportunity to spend time in the laboratories of Novo Nordisk (both in Oxford and Denmark). This distribution of time will depend on the specific project. You will conduct the research project selected, and produce novel scientific data and a thesis of suitable quality to obtain a DPhil (PhD). You should have prior research experience (typically a BSc), a medical degree and some specialist experience, typically having obtained MRCP or equivalent, but not CCT or consultant status. You will also have a strong CV, having published in international journals. You will be committed to a career in diabetes or metabolic medicine, clinical practice and research and have evidence of excellent interpersonal skills and leadership. Please note that while we will consider all applications, the funding provided for the Clinical Research Training Fellowship will only cover home/EU DPhil fees. The start date for successful candidates is ideally in Autumn 2019 however a start date earlier than autumn and as late as January or February 2020 may also be possible. Further information is detailed in the job description. The closing date for applications is 12.00 noon on Friday 22 March 2019. </div>

Novo Nordisk Postdoctoral Research Fellow in Diabetes and Metabolism (4 posts)

Closes: March 22, 2019, noon; salary: Grade 7: £32,236 - £39,609 p.a.

<div> Novo Nordisk is funding a prestigious fellowship programme at the University of Oxford for both basic science and clinical researchers, focused on diabetes research. We are looking to recruit four outstanding postdoctoral researchers who can utilise the support offered by this programme to become future leaders in the field, developing scientific excellence within diabetes and ultimately improving patients lives. In Oxford, world-class diabetes research is conducted across the spectrum of population, clinical and basic science. Depending on the project selected, you will be based in: 1) Oxford Centre for Diabetes, Endocrinology and Metabolism, 2) Division of Cardiovascular Medicine, 3) Department of Physiology, Anatomy and Genetics, 4) Nuffield Department of Medicine or, 5) The Kennedy Institute of Rheumatology. There is also the opportunity to spend time in the laboratories of Novo Nordisk (both in Oxford and Denmark). This distribution of time will depend on the specific project. You will be responsible for conducting the research project selected, including the production of novel scientific data and presentation at national and international meetings. You should have a PhD (completed or close to completion) in a biomedical subject, or other relevant subject, together with skills and experience relevant to biomedical research. You should be no more than 3 years post PhD at the start of the fellowship (Autumn 2019) and have a strong CV, having published in high impact journals and presented at international meetings. As well as an enthusiastic interest in diabetes research, you will have evidence of excellent interpersonal skills and leadership, with the ability to communicate research ideas and results in a clear and logical way. Further information is detailed in the job description. The closing date for applications is 12.00 noon on Friday 22 March 2019. </div>