All vacancies within Radcliffe Department of Medicine

There are currently 11 vacancies within Radcliffe Department of Medicine:

Title	Closes	Salary
Postdoctoral Research Scientist in Bioinformatics and Network Analysis	Oct. 24, 2018, noon	Grade 8: £40,792 - £48,677 with a discretionary range to £53,174 p.a.
Postdoctoral Research Scientist in Human Genetics	Oct. 24, 2018, noon	Grade 7: £32,236 - £39,609 with a discretionary range to £43,267 p.a.
Postdoctoral Research Scientist in Islet Genomics	Oct. 24, 2018, noon	Grade 7: £32,236 - £39,609 with a discretionary range to £43,267 p.a.
Postdoctoral Scientist in Drug Mechanism of Action Studies Acute Myeloid Leukaemia	Oct. 24, 2018, noon	Grade 7: £32,236 - £39,609 p.a.
Research Assistant in Human Metabolism	Oct. 24, 2018, noon	Grade 6: £28,660 p.a.
Apprentice Business Administrator	Oct. 25, 2018, noon	Apprentice Grade 1: £17,079 p.a. (salary progression through successful completion of programme)
Clinical Research Fellow	Oct. 25, 2018, noon	Grade E64: £31,931 - £51,176 p.a. (pro rata for part-time)
Postdoctoral Scientist in Medical Genetics	Oct. 26, 2018, noon	Grade 7: £32,236 - £39,609 p.a.
Postdoctoral Research Assistant	Nov. 2, 2018, noon	Grade 7: Salary in the range £32,236 - £36,261 p.a.
Postgraduate Research Assistant	Nov. 2, 2018, noon	Grade 6: £28,660 - £34,189 p.a.
Part-time Personal Assistant	Nov. 7, 2018, noon	Grade 5: £25,482 - £30,395 p.a. (pro rata)

Postdoctoral Research Scientist in Bioinformatics and Network Analysis

Closes: Oct. 24, 2018, noon; salary: Grade 8: £40,792 - £48,677 with a discretionary range to £53,174 p.a.

<div> We are seeking an ambitious and enthusiastic Postdoctoral Research Scientist to work within the world-leading research team headed by Professor Mark McCarthy at the Wellcome Centre for Human Genetics at the University of Oxford. The principal focus of this research post will be the development and implementation of network analysis and machine-learning methods to a number of multi-omic data sets that we have been generating. These projects (including DIRECT and MultiMUTHER) are focused on delivering a better understanding of the development and progression of type 2 diabetes, and its complications, and the data-sets we have generated are unique in terms of their sample sizes, depth of clinical and omic phenotyping, and the repeated measures available. Analysis of these data-sets calls for the application of innovative approaches to the analysis of large-scale, longitudinal, multiomic data that we have been developing with colleagues in Oxford and elsewhere. This post will provide opportunities to develop a specific focus in these or other areas, enabling the successful candidate to build evidence of independent working to support subsequent funding and fellowship applications. Candidates should hold a PhD/DPhil or equivalent degree in biochemistry, molecular biology, computer sciences, bioinformatics or a closely related field, and postgraduate expertise (in academia or industry) in the analysis of large, complex, biological data sets, including (ideally) network and machine learning approaches. The position is full-time, fixed-term for 2 year in the first instance. Please quote reference 136833 on all correspondence. You will be required to upload a CV and supporting statement as part of your online application. Only applications received before 12.00 midday on 24 October 2018 can be considered. </div>

Postdoctoral Research Scientist in Human Genetics

Closes: Oct. 24, 2018, noon; salary: Grade 7: £32,236 - £39,609 with a discretionary range to £43,267 p.a.

<div> We are seeking an enthusiastic, ambitious Postdoctoral Research Scientist to work within the world-leading research team headed by Professor Mark McCarthy at the Wellcome Centre for Human Genetics at the University of Oxford. The principal focus of this post involves research to detect and characterize genetic variants associated with type 2 diabetes and its complications. The post will involve analysis and interpretation of large-scale human genetic data (generated by GWAS and exome sequencing) for phenotypes such as diabetic nephropathy and neuropathy, and the integration of large-scale genetic and epigenomic data to provide mechanistic insights and translational opportunities. The research will have a strong collaborative dimension, involving interaction with colleagues in Europe and North America. In addition to these project-related activities, the person in post will have ample opportunities to develop their own research interests and projects, enabling them to build evidence of independent research working that can support subsequent funding and fellowship applications. We encourage members of the group to support science outreach through public engagement and social media. Candidates should hold or be close to completion of a PhD/DPhil or equivalent degree in biochemistry, molecular biology, bioinformatics, statistical genetics, or a closely related field. They should have experience in the analysis of large genetic and genomic data-sets and strong programming skills. The position is full-time, fixed-term for 2 years in the first instance. Please quote reference 136830 on all correspondence. You will be required to upload a CV and supporting statement as part of your online application. Only applications received before 12.00 midday on 24 October 2018 can be considered. </div>

Postdoctoral Research Scientist in Islet Genomics

Closes: Oct. 24, 2018, noon; salary: Grade 7: £32,236 - £39,609 with a discretionary range to £43,267 p.a.

<div> We are seeking an enthusiastic, ambitious Postdoctoral Research Scientist to work within the world-leading research team headed by Professor Mark McCarthy at the Wellcome Centre for Human Genetics at the University of Oxford. The main focus involves the analysis of a wide range of functional sequencing data (including RNA-Seq, ATAC-Seq, whole genome methylation sequencing) that we have generated from human islets and cell-lines (including differentiated stem cells). The role involves responsibilities for the QC and analysis of existing and ongoing data sets and their integration of those data with other relevant genetic, epigenomic, cellular and molecular data to which we have access. We are also increasingly deploying single-cell methods including CROP-Seq to characterise the consequences of gene perturbation, and the person in this post will lead on these efforts. The research will have a strong collaborative dimension, involving interaction with colleagues in Europe and North America. In addition to these project-related activities, the person in post will have ample opportunities to develop their own research interests and projects, enabling them to build evidence of independent research working that can support subsequent funding and fellowship applications. We encourage members of the group to support science outreach through public engagement and social media. Candidates should hold or be close to completion of a PhD/DPhil or equivalent degree in biochemistry, molecular biology, bioinformatics, statistical genetics, or a closely related field. They should have experience in the analysis of large genetic and genomic data-sets and strong programming and computational skills. The position is full-time, fixed-term for 2 years in the first instance. Please quote reference 137186 on all correspondence. You will be required to upload a CV and supporting statement as part of your online application. Only applications received before 12.00 midday on 24 October 2018 can be considered. </div>

Postdoctoral Scientist in Drug Mechanism of Action Studies Acute Myeloid Leukaemia

Closes: Oct. 24, 2018, noon; salary: Grade 7: £32,236 - £39,609 p.a.

<div> A unique opportunity for a driven, highly motivated and talented postdoctoral scientist to join the research group of Professor Thomas Milne at the MRC Weatherall Institute of Molecular Medicine (WIMM). You will work in a University-industry collaboration to discover and functionally test new lead therapeutic compounds for treatment of the most common aggressive human acute leukaemia, Acute Myeloid Leukaemia (AML). The position is fixed-term until 1 November 2019, funded by an innovative new spin-out company OxStem Oncology (www.oxstem.co.uk/product-pipeline/oncology) and will involve collaborations with Professor Paresh Vyas (WIMM) and the University Department of Chemistry (Professor Steven Davies and Angela Russell). The Milne lab focuses on epigenetics of haemopoiesis, the Vyas lab has a long-standing interest in the biology of normal and leukaemic stem cells, and the Davies/Russell labs have made rich small molecule compound libraries. Traditionally, cancer therapies have focussed on killing tumour cells. In a highly novel approach, OxStem Oncology has performed screens to identify molecules that cure leukaemia by releasing the differentiation block in AML. The postholder is a key team member who will play a pivotal role in functionally testing lead compounds and determining their mechanism of action. This will require flexibility as a wide range of different technical approaches will need to be used. You will hold a relevant PhD (or be near to completion), and will have experience in basic biochemistry techniques (including but not limited to column-based protein purification methods), experience with FACS analysis, basic molecular biology and cloning skills, and experience working with DNA and RNA and making next generation sequencing libraries. Previous experience with drug mechanism of action (MOA) studies or CRISPR/CAS9 screening will be considered an asset. You will have experience of managing your own time to meet project deadlines and to work independently as well as part of a team. Applications for this vacancy are to be made online. You will be required to upload a CV and supporting statement as part of your online application. The closing date for this position is 12.00 noon on Wednesday 24 October 2018. </div>

Research Assistant in Human Metabolism

Closes: Oct. 24, 2018, noon; salary: Grade 6: £28,660 p.a.

<div> An exciting opportunity has arisen for a Research Assistant, within Metabolic Research Group led by Professors Leanne Hodson and Fredrik Karpe in the Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM). The Metabolic Research Group applies an integrated approach to human metabolic disease which involves genetic, genomic, cell biology and whole body metabolic studies to understand the pathogenesis of the complications of obesity such as fatty liver disease, type 2 diabetes and cardiovascular disease. The successful applicant will join an interdisciplinary team from the Hodson and Karpe laboratories. They will assist in ongoing projects and the development of new projects using in vitro cellular models, to investigate the effect of specific nutrients on human metabolism. The post holder will have responsibility for both supporting and undertaking several key aspects of work within the lab including in vitro cell culture of human liver cells (primary and cell-lines), RNA extraction from human tissues and cells, and undertaking stable-isotope analysis. They will be responsible for managing their own time and resources within the context of their role, and the requirements and objectives associated with their position. The postholder will support the work of metabolic research group and report to Professor Leanne Hodson. Candidates should have relevant laboratory experience. The position is full-time, fixed-term for 6 months in the first instance, and funded by the BBSRC. Please quote reference 137658 on all correspondence. You will be required to upload a CV and supporting statement as part of your online application. Only applications received before 12.00 midday on 24 October 2018 can be considered. The Interviews will take place on 30 October 2018. </div>

Apprentice Business Administrator

Closes: Oct. 25, 2018, noon; salary: Apprentice Grade 1: £17,079 p.a. (salary progression through successful completion of programme)

<div> You will work as an Apprentice Business Administrator within the Oxford Centre for Diabetes Endocrinology and Metabolism (OCDEM) friendly and supportive team, providing clerical and administrative support to our Professors within the Department. You will have an interest in, and aptitude for all aspects of office administration. You will learn to provide support to our Professors and their teams, in the areas of diary management, event organisation, communications, training courses, recruitment and more. This is a unique opportunity for an enthusiastic and driven individual keen to gain practical administrative experience within a fast-paced and successful team. You will be allocated a primary set of duties (see below) and as your skills develop, there will be an opportunity to widen your skills, or focus on specific areas. The role is an excellent opportunity for someone who is interested in performing a diverse set of activities, someone who is capable of working at an efficient and fast pace, and willing to learn all aspects of a this admin role. Becoming an Apprentice at the University of Oxford is an excellent opportunity to gain practical experience and training. For more information visit: www.apprenticeships.ox.ac.uk The position is full-time and fixed-term for 18 months in the first instance. Please quote reference 137540 on all correspondence. You will be required to upload a CV and supporting statement as part of your online application. Please apply via the <a rel="nofollow" href="https://www.findapprenticeship.service.gov.uk/apprenticeship/-347998">apprenticeship website</a> Only applications received by 12.00 midday on 25 October 2018 can be considered. The interviews will be held on Monday 5 November 2018. </div>

Clinical Research Fellow

Closes: Oct. 25, 2018, noon; salary: Grade E64: £31,931 - £51,176 p.a. (pro rata for part-time)

<div> A Clinical Research Fellowship in the Radcliffe Department of Medicine is available to start in circa January 2019. The post is an excellent opportunity for candidates interested in acquiring multicentre trial experience while contributing to a project focussed on the cardiothoracic surgical population. The post is to work on a multicentre placebo-controlled randomised clinical trial investigating the efficacy of a novel cardioprotective drug in the setting of on pump cardiac surgery in adult patients. You will be working closely with a multi-disciplinary team of clinicians from intensive and cardiothoracic critical care, anaesthetics, cardiothoracic surgery, trial project managers and clinician scientists. You will be expected to drive the clinical aspects of the study and play a broad role within the study including protocol design and amendments, recruitment, endpoint acquisition and sub study sample acquisition and analysis which may involve and be based partly with external collaborators. You will have a full GMC registration and you will have successfully completed at least full-time hospital training to at least the start of higher level, i.e. ST5 (or equivalent), in anaesthetic/critical care medicine. You will have MBBS or an equivalent qualification, previous relevant research experience with evidence of peer reviewed publications as well as demonstrable prior experience in the management of cardiothoracic critically unwell patients. Certified level experience of echocardiographic imaging on the critical care unit would be advantageous. You should also have the ability to work within a team and the level of clinical experience necessary to communicate effectively with clinical colleagues from anaesthetic, cardiothoracic and critical care backgrounds. The successful candidate would be encouraged to register for a DPhil (PhD) at the University of Oxford, the funding for which would be provided by SBI Pharmaceuticals Ltd. This post is full-time and fixed-term until 31 December 2021 in the first instance, with the possibility of extension. Part-time working will be considered at a minimum of 0.8 FTE. Applications for flexible working arrangements are welcomed and will be considered in line with business needs. You will be required to upload a CV and supporting statement as part of your online application. Owing to the nature of this position, any offer of employment with the University will be subject to a satisfactory security screening and a satisfactory disclosure report from the Disclosure and Barring Service. For further information please contact Dr Mark Butler (<a rel="nofollow" href="mailto:mark.butler@rdm.ox.ac.uk">mark.butler@rdm.ox.ac.uk</a>) or Felicity Green (<a rel="nofollow" href="mailto:felicity.green@rdm.ox.ac.uk">felicity.green@rdm.ox.ac.uk</a>). To apply for this post please read the job description in full and then click on the apply now button below. The closing date for applications is 12.00 midday on 25 October 2018 with interviews anticipated to take place in early November 2018. </div>

Postdoctoral Scientist in Medical Genetics

Closes: Oct. 26, 2018, noon; salary: Grade 7: £32,236 - £39,609 p.a.

<div> Project: New technologies to decipher the non-coding genome: clinical application to craniosynostosis We are seeking a motivated and enthusiastic Postdoctoral Scientist with extensive laboratory and organisational skills to join an ongoing project led by Dr Steve Twigg within the Clinical Genetics Group. The aim of the work is to investigate non-coding variation in the skull malformation craniosynostosis. Applicants must hold (or be near to completion of) a PhD in a relevant discipline and have previous experience in molecular biology such as PCR, sequencing, DNA/RNA extraction, ideally applied to human or mammalian genetics. The ability to work both as a team member and independently, together with a meticulous approach to lab work, with good manual dexterity, attention to details and excellent organisational and communication skills will be essential. The post is available immediately, fixed-term until 31 March 2019 and iws funded by Action Medical Research. Informal enquiries may be sent to <a rel="nofollow" href="mailto:stephen.twigg@imm.ox.ac.uk">stephen.twigg@imm.ox.ac.uk</a>. Applications for this vacancy are to be made online. You will be required to upload a CV and supporting statement as part of your online application. The closing date for this position is 12.00 midday on Friday 26 October 2018. </div>

Postdoctoral Research Assistant

Closes: Nov. 2, 2018, noon; salary: Grade 7: Salary in the range £32,236 - £36,261 p.a.

<div> We are looking for a well-trained, highly motivated and academically excellent Research Assistant to join our research team and become a member of the Inherited Heart Muscle Disease Group led by Professor Hugh Watkins FRS FMedSci. A significant focus for the post is to investigate the role of the innate immune system in cardiac tissue remodelling in response to dysfunctional cardiomyocytes carrying myofilament mutation(s) using the HCM mouse models. The work will employ the cutting edge single cell genomic approaches, well-established in vivo mouse models, advanced immunological and imaging techniques (e.g. FACSymphony, cell sorting, CyTOF, two-photon confocal fluorescence microscopy, and light sheet microscopy), leading to the identification of new targets for therapy for families with cardiomyopathy. You will hold a PhD degree in immunology, molecular and cell biology or similar and have the capacity to deliver high quality research outputs, as illustrated by a strong publication record in high profile immunological journals. Proven experience in macrophage biology is desirable. This full-time appointment is fixed-term until 9 September 2023 and you will work under the supervision of Professor Houman Ashrafian, Professor Charles Redwood and Professor Hugh Watkins in the Division of Cardiovascular Medicine in collaboration with Professor Vincenzo Cerundolo at the MRC Human Immunology Unit at the Weatherall Institute of Molecular Medicine. You will be based at the Wellcome Centre for Human Genetics, Roosevelt Drive Oxford. Applications for this vacancy are to be made online; you will be required to upload a CV and supporting statement which explains how you meet the selection criteria for the post. Only applications received before 12.00 midday on 2 November 2018 can be considered. Interviews are scheduled to place on 16 November 2018. </div>

Postgraduate Research Assistant

Closes: Nov. 2, 2018, noon; salary: Grade 6: £28,660 - £34,189 p.a.

<div> We are looking for a well-trained, highly motivated and academically excellent Research Assistant to join our research team and become a member of the Inherited Heart Muscle Disease Group led by Professor Hugh Watkins FRS FMedSci. Your primary role would be to undertake research projects aimed at understanding the role of immune cells in pathogenesis of HCM. As a Research Assistant, you will also contribute to the projects of other researchers in the lab and help with general lab management. You will also manage your own research and administrative activities, within guidelines provided by senior colleagues and contribute to wider project planning, including ideas for new research projects You will hold a degree (first class or 2:1) in in immunology/cardiovascular or related biological sciences and possess sufficient specialist knowledge in the discipline to work within established research programmes. Proven experience in flow cytometry/cell sorting is desirable. This full-time appointment is fixed-term until 9 September 2023 and you will work under the supervision of Dr Ying-Jie Wang. You will be based at the Wellcome Centre for Human Genetics, Roosevelt Drive Oxford. Applications for this vacancy are to be made online; you will be required to upload a CV and supporting statement which explains how you meet the selection criteria for the post. Only applications received before 12.00 midday on 2 November 2018 can be considered. Interviews are scheduled to place on 16 November 2018. </div>

Part-time Personal Assistant

Closes: Nov. 7, 2018, noon; salary: Grade 5: £25,482 - £30,395 p.a. (pro rata)

<div> We are seeking a personal assistant to provide a wide range of administrative support to Professor Shoumo Bhattacharya. You will work in a demanding environment and will require mature judgement and intellectual flexibility, as well as good communication skills, both verbal and written. The personal assistant is responsible for ensuring the smooth functioning of the work of Professor Bhattacharya, which is unusually complex because of the range of activities, the demands upon time and the senior level of much of the interaction. You will need to maintain an overview of projects and work in progress, assess the priorities of these, and prompt and bring forward documents at the appropriate time, ensuring that tasks are completed within the given timescales. You will also need to be educated to A-Level or equivalent qualification and have proven PA experience in a similar environment with the demonstrated ability to effectively manage a portfolio. This is a part-time post working four half-days per week (total 14.6 hours), and is fixed-term for 3 years with a possible extension. You will be based at the Wellcome Centre for Human Genetics, Old Road Campus, Oxford. Applications for this vacancy are to be made online; you will be required to upload a supporting statement and a copy of your CV as part of your online application. Only applications received before 12.00 midday on 7 November 2018 can be considered. Interviews are anticipated to take place in the week commencing 19 November 2018. </div>