Postdoctoral Research Associate in Single Molecule Bacterial Protein Import

<div xmlns="http://www.w3.org/1999/xhtml"> <p></p><div><strong>About the role</strong></div><br> <div>&#160;</div><br> <div>We are seeking to appoint a Postdoctoral Research Associate with expertise in biochemical and/or biophysical approaches to investigate the mechanism by which antimicrobial proteins known as bacteriocins are transported across the E. coli outer membrane. The project is the result of recent collaborative advances made in the laboratories of Prof Colin Kleanthous (Biochemistry) and Dominika Gruszka (Physics/Kavli Institute) in Oxford.</div><br> <div>&#160;</div><br> <div>The post will exploit a new live-cell imaging/microfluidics system that has been developed to reveal the underlying import kinetics and energetics for these protein antibiotics at the single molecule level, which could ultimately be used to engineer novel antimicrobials for drug-resistant bacteria.</div><br> <div>&#160;</div><br> <div>This full-time fixed-term post is funded by the BBSRC for up to 3 years in the first instance and is based in the Department of Biochemistry and the Kavli Institute for Nanoscience Discovery in the Dorothy Crowfoot Hodgkin Building, South Parks Road, Oxford.</div><br> <div>&#160;</div><br> <div>The actual starting salary offered will be based on qualifications and relevant skills acquired and will also be determined by the funding available. <strong>(This is unlikely to be more than &#163;38,205 per annum).</strong></div><br> <div>&#160;</div><br> <div><strong>About you</strong></div><br> <div>&#160;</div><br> <div>Applicants should hold a PhD/DPhil or be near completion of PhD/DPhil in Biochemistry, Molecular Biophysics or a related area and have experience in dissecting biological mechanisms using biochemical/biophysical methods specific to a particular area of research.&#160; You will have experience in recombinant DNA molecular biology methods and expressing and purifying recombinant proteins.&#160; The ability to demonstrate competence and success in solving biological problems through research as judged by publications in high quality peer reviewed journals is essential together with willingness to learn new techniques and apply them in an interdisciplinary research environment.&#160; You will be motivated and have good organisational skills in order to work with minimum supervision and have the ability to communicate well in writing, oral and visual presentations.</div><br> <div>&#160;</div><br> <div><strong>Application Process</strong></div><br> <div>&#160;</div><br> <div>If you would like to discuss this role please contact one of our HR Team on 01865 613200 or jobs@bioch.ox.ac.uk</div><br> <div>&#160;</div><br> <div>You will be required to upload a supporting statement, setting out how you meet the selection criteria, curriculum vitae and the names and contact details of two referees as part of your online</div><br> <div>&#160;</div><br> <div>Only applications received before <strong>12 noon</strong> on <strong>Friday 6th October 2023</strong> can be considered.</div><br> <div>&#160;</div><br> <div>Interviews will be held week commencing <strong>Monday 9th October 2023</strong>.</div><br> <div>&#160;</div><br> <div><strong>Committed to equality and valuing diversity</strong></div> </div>