Postdoctoral Researcher in DNA Damage Signalling
Applications for this vacancy closed on 27 October 2023 at 12:00PM
**About the role**
Applications are invited for a Cancer Research UK funded postdoctoral position
in Prof. Andrew Blackford’s lab. The aim of the lab’s research is to
understand how DNA double-strand break repair protein complexes are regulated
at the molecular level, and to exploit this knowledge for therapeutic benefit.
Prof. Andrew Blackford’s lab recently identified a novel protein complex that
we proposed is required to hold broken chromosomes together while cells are
attempting chromosome segregation (Leimbacher et al., Mol. Cell 2019). More
recent evidence indicates that some cancer cells are particularly reliant on
this pathway for their survival. We therefore hypothesise that enzymatic
activities associated with it may be novel drug targets to kill tumours with
certain genetic vulnerabilities. However, we still have a poor understanding
of how this protein complex is regulated, its structure and contribution to
tumour suppression and human health.
The successful candidate will attempt to answer these questions, using a
combination of CRISPR-Cas9 gene-editing, live-cell super-resolution
microscopy, biochemistry and cell biology techniques.
This role is offered on a full-time basis and is fixed term for 3 year in the
first instance.
**About you**
You should possess (or be nearing completion of) a PhD/DPhil in a relevant
field such as cell biology or molecular biology. Essential experience includes
mammalian cell culture, immunofluorescence microscopy, plasmid design and
cloning. A keen attention to detail, high motivation, and excellent
communication skills, including writing for publication and presenting
research, are crucial. Ideally, you'll have a background in areas like DNA
damage response, DNA replication, cell cycle, mitosis or related areas of
chromosome biology. Experience in biochemistry, bioinformatics, proteomics,
lentivirus transduction, CRISPR-Cas9 gene-editing, and/or super-resolution
microscopy, is a plus. Having a first author paper published in a reputable
journal or a manuscript under review would be advantageous.
**Application process**
If you would like to discuss this role please contact Prof. Andrew Blackford
on andrew.blackford@imm.ox.ac.uk
You will be required to upload a supporting statement (setting out how you
meet the selection criteria), a curriculum vitae and the names and contact
details of two referees as part of your online application.
The closing date for applications is 12.00 noon on 27th October 2023.
Applications are invited for a Cancer Research UK funded postdoctoral position
in Prof. Andrew Blackford’s lab. The aim of the lab’s research is to
understand how DNA double-strand break repair protein complexes are regulated
at the molecular level, and to exploit this knowledge for therapeutic benefit.
Prof. Andrew Blackford’s lab recently identified a novel protein complex that
we proposed is required to hold broken chromosomes together while cells are
attempting chromosome segregation (Leimbacher et al., Mol. Cell 2019). More
recent evidence indicates that some cancer cells are particularly reliant on
this pathway for their survival. We therefore hypothesise that enzymatic
activities associated with it may be novel drug targets to kill tumours with
certain genetic vulnerabilities. However, we still have a poor understanding
of how this protein complex is regulated, its structure and contribution to
tumour suppression and human health.
The successful candidate will attempt to answer these questions, using a
combination of CRISPR-Cas9 gene-editing, live-cell super-resolution
microscopy, biochemistry and cell biology techniques.
This role is offered on a full-time basis and is fixed term for 3 year in the
first instance.
**About you**
You should possess (or be nearing completion of) a PhD/DPhil in a relevant
field such as cell biology or molecular biology. Essential experience includes
mammalian cell culture, immunofluorescence microscopy, plasmid design and
cloning. A keen attention to detail, high motivation, and excellent
communication skills, including writing for publication and presenting
research, are crucial. Ideally, you'll have a background in areas like DNA
damage response, DNA replication, cell cycle, mitosis or related areas of
chromosome biology. Experience in biochemistry, bioinformatics, proteomics,
lentivirus transduction, CRISPR-Cas9 gene-editing, and/or super-resolution
microscopy, is a plus. Having a first author paper published in a reputable
journal or a manuscript under review would be advantageous.
**Application process**
If you would like to discuss this role please contact Prof. Andrew Blackford
on andrew.blackford@imm.ox.ac.uk
You will be required to upload a supporting statement (setting out how you
meet the selection criteria), a curriculum vitae and the names and contact
details of two referees as part of your online application.
The closing date for applications is 12.00 noon on 27th October 2023.
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Department of Oncology, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK
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| vacancy:applicationClosingDate |
2023-10-27 12:00:00+01:00
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| vacancy:applicationOpeningDate |
2023-09-26 09:00:00+01:00
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| vacancy:internalApplicationsOnly |
False
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| vacancy:salary | |
| type | |
| comment |
**About the role**
Applications are invited for a Cancer Research UK funded postdoctoral position in Prof. Andrew Blackford’s lab. The aim of the lab’s research is to understand how DNA double-strand break repair protein complexes are regulated at the molecular level, and to exploit this knowledge for therapeutic benefit. Prof. Andrew Blackford’s lab recently identified a novel protein complex that we proposed is required to hold broken chromosomes together while cells are attempting chromosome segregation (Leimbacher et al., Mol. Cell 2019). More recent evidence indicates that some cancer cells are particularly reliant on this pathway for their survival. We therefore ... About the role Applications are invited for a Cancer Research UK funded postdoctoral position in Prof. Andrew Blackford’s lab. The aim of the lab’s research is to understand how DNA double-strand break repair protein complexes are regulated at the molecular level, and to exploit this knowledge for therapeutic benefit. Prof. Andrew Blackford’s lab recently identified a novel protein complex that we proposed is required to hold broken chromosomes together while cells are attempting chromosome segregation (Leimbacher et al., Mol. Cell 2019). More recent evidence indicates that some cancer cells are particularly reliant on this pathway for their survival. We therefore ... |
| label |
Postdoctoral Researcher in DNA Damage Signalling
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| notation |
168332
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| based near |