Postdoctoral Research Scientist in Pre-clinical MRI Methods

We are looking for a **Postdoctoral Research Scientist in Pre-clinical MRI
Methods** to join the MRI Physics group at the Wellcome Centre for Integrative
Neuroimaging (WIN, formerly FMRIB), NDCN. We have recently launched a research
programme aiming to translate population imaging studies like the UK Biobank
into the broader environment of basic and clinical neuroscience. We are now
seeking someone to lead the pre-clincial (rodent) arm of this research
programme.





The postholder will use rodent models to identify and interpret the cellular
features that drive MRI signals. We will perform measurements in mice to
identify the biological sources of MR-visible cellular “compartments”. For
this, we will use sophisticated multi-dimensional quantitative MRI techniques
alongside the acquisition of multiple histological immunostains in rodent
tissue samples. These experiments, which aim to confer neurobiological meaning
to the identified compartments, will be done in a range of mouse models with
specific alterations to cellular features of interest (e.g., myelin).





These experiments will align to and be integrated with similar human
experiments from our broader research programme. This will enable us: (i) to
provide biophysically informed methods for “harmonising” human data in the UK
Biobank to new settings, (ii) to precisely prediction how microstructural
alterations alter MRI signals, and (iii) to design imaging protocols that are
maximally sensitive to specific pathology.





The post holder will be expected to take an independent and proactive role in
managing the research process, maintaining and setting up collaborations, and
generating new research and grant opportunities. They will be responsible for
supervising students and research assistants, both in relation to the
postholder’s research project and related projects.





The successful candidate will hold a PhD/DPhil in Engineering, Physics or
related subject. They will also have experience with MRI experimental
techniques for studying rodent biology, including protocol development image
acquisition, and signal modelling, with quantitative MRI, including diffusion,
quantitative susceptibility mapping, quantitative MRI and structural imaging,
and with light microscopy acquisition and analysis, including immunostaining,
structure tensor analysis, semi-quantitative analysis.





Please see the below 'Job Description' for further details on the
responsibilities and selection criteria, as well as further information about
the university and how to apply.





**This post is full time and fixed term for 3 years.**





**Only applications received before 12:00 midday on Monday 11th March 2024
will be considered.**





**Interviews will be held as soon as possible thereafter. **