Postdoctoral Research Assistant

<div xmlns="http://www.w3.org/1999/xhtml"> <p></p><div>We are seeking an enthusiastic Postdoctoral Research Assistant to work within a vibrant research team headed by Professor David Hodson at the Oxford Centre for Diabetes Endocrinology and Metabolism (OCDEM) on studies related to type 1 diabetes (https://www.rdm.ox.ac.uk/people/david-hodson).</div><br> <div>&#160;</div><br> <div>The postholder will contribute to a Steve Morgan Foundation Type 1 Diabetes Grand Challenge, which is led by Oxford together with partners at the University of Birmingham and FMP Leibniz Berlin. The overarching aims of the Grand Challenge are to:&#160;</div><br> <div>1) Produce better functioning stem cell-derived beta cells to ensure long-lasting insulin-independence in people living with type 1 diabetes (T1D)</div><br> <div>2) Precision deliver therapy to the pancreatic beta cell surface that can fend off immune attack in the early stages of T1D</div><br> <div>3) Coax alpha cells, which survive immune destruction during T1D, to convert into insulin-positive cells to provide a new supply of beta cells without the need for transplantation.&#160;</div><br> <div>To allow this, we will target two surface receptors, which are highly expressed by alpha cells and beta cells. The major goal is to help improve stem cell-derived beta cell survival and function, allow immunotherapy to work better for longer with fewer side effects, and provide more evidence that endogenous beta cells can be regenerated, together making beta cell replacement a possibility for more people living with T1D.</div><br> <div>&#160;</div><br> <div>Although full training will be given in a variety of techniques, the person appointed will be expected to work independently on most tasks or in collaboration with the support of colleagues. Methods will include cell culture, stem cell-derived beta cell generation, hormone assays, sequencing, cloning and optical imaging.</div><br> <div>&#160;</div><br> <div>The position would suit a cell biologist with experience of imaging, molecular genetics and cell culture. A background in diabetes or metabolism is desirable.</div><br> <div>&#160;</div><br> <div>The position, funded by a Steve Morgan Foundation Type 1 Diabetes Grand Challenge, and is offered as a full time post and fixed term for 2 years. The position will be based at OCDEM, Churchill Hospital, Headington, Oxford.</div><br> <div>&#160;</div><br> <div>For informal enquiries, please contact Supprina Thebe at ocdem.personnel@ndm.ox.ac.uk. Please quote reference 173446 on all correspondence.</div><br> <div>&#160;</div><br> <div>As part of your formal online application, you will be required to upload a CV and supporting statement. Only applications received before midday on 19 June 2024 can be considered. Interviews will be held on the week commencing 24 June 2024.</div> </div>