Postdoctoral Researcher in Cellular Therapeutics

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**NUFFIELD DEPARTMENT OF SURGICAL SCIENCES**





**Grade 7:** **£ 36,024 - £44,263** **per annum**



**Location:** **Institute of Developmental & Regenerative Medicine, Old Road
Campus, Roosevelt Drive, Headington, Oxford, OX3 7TY**



**Contract type:** **Fixed-term contract until 30th June 2026**



**Hours: Full-time**





**About the role**



We are looking for a post-doctoral researcher to work in Translational
Research Immunology Group (TRIG) on translational, collaborative project
funded by EU. You will be placed in the Institute of Developmental and
Regenerative Medicine on the Old Road Campus working in a close collaboration
with the Oxford Kidney Pathology group.





You will be part of a bigger EU-funded project which goal is to develop a safe
and efficient cell therapy based on genome edited T cells for IgA nephropathy
(IgAN). IgAN is the most common glomerulonephritis; IgA-rich complexes are
deposited in renal glomeruli, leading to renal failure a third of cases, but
there are currently no effective treatments, so this an area of significant
unmet need. Redirected T cells offer the potential to specifically target
pathogenic IgA1 producing cells.





You will work closely with members of TRIG and Oxford Kidney Pathology groups,
including students, other post-docs and research assistants as well as
international collaborators within the EU consortium. You will be responsible
for testing T cell therapeutics developed by our consortium, using in vivo
models of glomerular immune complex disease as well as the establishment of a
novel model for IgA Nephropathy. Additionally, you will contribute to spatial
transcriptomics and proteomics in human IgAN kidney samples.





**About you**



You will hold a PhD (or be near to completion: thesis submitted) in a relevant
area at the time of application and will have experience in immunology or
kidney disease field. Experience with cell culture techniques, animal models
and immunological techniques is required. You will have demonstrated the
ability to work independently within projects, with the ability to communicate
results clearly and succinctly in presentations, manuscripts and grant
applications. Experience with flow cytometry and genetic editing techniques as
well as knowledge of kidney disease are desirable.





This full-time post is available immediately and is fixed-term until June 2026
in the first instance.





**Application Process**



If you would like to discuss this role, please contact Fadi Issa,
fadi.issa@nds.ox.ac.uk.





Applications for this vacancy are to be made online. You will be required to
upload a supporting statement, setting out how you meet the selection
criteria, curriculum vitae and the names and contact details of two referees
as part of your online application. Please quote reference NDSA926 on all
correspondence.





Only applications received before noon 5th July 2024 can be considered.





Interviews will be held on Thursday 18th July 2024.





**Committed to equality and valuing diversity**