Clinical Research Fellow in Cardiovascular Science

<div xmlns="http://www.w3.org/1999/xhtml"> <p></p><div>We are seeking a highly motivated Clinical Research Fellow to drive a translational programme of work in the division of Cardiovascular Medicine in Oxford, that aims to investigate the effects of a novel antidiabetic drug on the cardiovascular system and that relies on the Oxford Heart Vessels and Fat (ox-HVF) Programme. Ox-HVF studies the interplay between the cardiovascular system and adipose tissue. This is a flagship programme that has recruited so far &gt;1500 patients undergoing cardiac surgery, and has built the world&#8217;s largest and most sophisticated clinical cohort, with biopsies (and RNAsequencing data) from 6 different adipose tissue depots, arteries, veins and myocardial tissue, ex vivo phenotypic characterization of all these samples, all of which are linked with up to 15 years outcomes data of the patients and repeated Computed Tomography Angiography imaging data for disease progression. The post-holder will investigate the effects of the novel antidiabetic drug on vascular and myocardial tissue by performing ex vivo assays on samples obtained from patients recruited under the ox-HVF programme. They will also take advantage of the transcriptomic data from hundreds of ox-HVF human samples obtained from the heart and the vessels and of Mendelian randomisation approaches, as well as they will perform in vitro experiments, to investigate the underlying molecular mechanisms.</div><br> <div>&#160;</div><br> <div>RESPONSIBILITIES</div><br> <div>&#8226; Recruitment and consenting patients for research if needed</div><br> <div>&#8226; Collection (from cardiac surgery) and processing (in the ox-HVF labs) of human tissues and blood samples</div><br> <div>&#8226; Perform functional bioassays on human tissues and primary cells (wet lab experiments) under the supervision of an experienced post-doctoral scientist</div><br> <div>&#8226; Preparation and presentation of research findings at the group and departmental meetings</div><br> <div>&#8226; Preparation of progress reports on research and ensuring the lab books and electronic records are fully up to date and can be kept as a record of the research</div><br> <div>&#8226; Day-to-day laboratory housekeeping: e.g. setting-up and clearing away equipment, ordering lab supplies, maintaining laboratory in clean and orderly fashion</div><br> <div>&#8226; Flexibility (when human tissue/blood collection is involved and/or cell culture experiments are concerned)</div><br> <div>&#160;</div><br> <div>&#160;</div><br> <div>Essential selection criteria</div><br> <div>&#8226; Primary medical degree, such as medicine (MD/MBBS) -GMC registration not essential for the role</div><br> <div>&#8226; Academic background in medical research and the motivation and ability to undertake and contribute to the research programmes.</div><br> <div>&#8226; Excellent organisational, communication and professional skills to work effectively in a diverse team of basic scientists, medical clinicians, and others.</div><br> <div>&#8226; Excellent personal and interpersonal skills, both in-person and online, that result in professional and respectful relationships with all team members.</div><br> <div>&#8226; Fluency in English (should be proficient in medical and academic English and have published academic research in English).</div><br> <div>&#160;</div><br> <div>Desirable selection criteria&#160;</div><br> <div>&#8226; A personal publication history that demonstrates passion for translational cardiovascular research&#160;</div><br> <div>&#8226; Documented experience in wet lab research</div><br> <div>&#160;</div><br> <div>This is a full-time appointment on a fixed term contract for 2 years funded by Lexicon Pharmaceuticals and you will be based at the West Wing, John Radcliffe Hospital, Oxford, OX3 9DU.</div><br> <div>&#160;</div><br> <div>Applications for this vacancy are to be made online; you will be required to upload a CV and supporting statement which explains how you meet the selection criteria for the post.&#160;</div><br> <div>&#160;</div><br> <div>Only applications received before 12.00 midday on <strong>20 August 2024</strong> can be considered. Interviews are scheduled to place in September &#160;</div><br> <div>&#160;</div><br> <div>The University is an Equal Opportunity Employer</div> </div>