Postdoctoral Researcher - Protein Biochemist and Physicist

We have an exciting opportunity to recruit a Postdoctoral Researcher to join
the Centre for Medicines Discovery (CMD) and its Biochemistry and Biophysics
Group led by Dr. Oleg Fedorov. You will work alongside structural biologists
and molecular biologists in the CMD and to discover novel therapeutic
approaches to various human diseases.





CMD mission is to de-risk novel therapeutic approaches and discover novel
agents fit for further discovery investment. Consequently, we work closely
with pharma and biotech companies and operate industry-style project teams to
deliver our target validation and translational goals.





This post provides an opportunity to work on a variety of projects in all
biology areas in a uniquely collaborative academic department in which to
work; the freedom and flexibility, offered by an academic research
environment, in which to train and develop your initiatives and capabilities.





You will be responsible for developing biochemical, biophysical, and target
engagement assays, and utilising them to identify and evaluate ligands for the
proteins of interest. You will be executing bench-level experiments with the
expectation of being able to write protocols, design experimental plans,
develop new scientific techniques, and contribute and develop ideas for new
research projects. You will also be independently using and managing
specialist scientific equipment in a laboratory environment, such as Echo
(automated liquid handling), Pherastar plate readers, Biacore (SPR), ITC,
Octet (BLI), RapidFire mass spectrometry (Agilent).





To be successful in this role, you will hold a PhD/DPhil (or be close to
completion) in Biochemistry, Biophysics, Pharmacology, or other similar
subject along with a background in protein biochemistry/enzymology with
experience in the determination of drug mechanism of action and analysis of
thermodynamics and kinetics. You will have previous experience of in vitro
assay development including one or more of: biochemical, biophysical assays,
protein-protein interaction assays and/or cellular target engagement assays
(e.g. HTRF, enzyme activity assays, BLI, SPR, mass spectrometry) and possess
excellent interpersonal, oral, and written communication skills along with the
ability to communicate well and to collaborate effectively within a dynamic
team and matrix environment.





Applications for this vacancy are to be made online and you will be required
to upload a supporting statement and CV as part of your online application.
Your supporting statement must explain how you meet each of the selection
criteria for the post using examples of your skills and experience.





This position is offered full time on a fixed term contract until 31 July 2026
and is funded by the Department.





Only applications received before 12 midday on Tuesday 5 November 2024 will be
considered. Interviews to be hold the week commencing 18 November 2024. Please
quote **175445** on all correspondence.