Senior Research Scientist in Mass Spectrometry-based Immunopeptidomics
Applications for this vacancy closed on 9 June 2025 at 12:00PM
We are seeking to appoint a highly motivated Senior Research Scientist in Mass
Spectrometry-based Immunopeptidomics with a strong interest in cancer
immunology and innovative approaches for antigen discovery in cancer. You will
have hands-on experience with mass spectrometry-based proteomics, including
instrument operation, maintenance and data analysis workflows. You will
contribute to a research programme focused on deciphering the molecular
architecture of the HLA antigen processing and editing machinery, and
investigating how it shapes tumour-specific antigen presentation. Your project
will focus on identifying tumour-specific and immunogenic antigens from
primary tumour tissues using advanced immunopeptidomics approaches as part of
a multi-team initiative to design and deliver cancer-preventing vaccines
jointly led by the University of Oxford and GSK.
You will be responsible for LC-MS/MS data acquisition and analysis,
development of sensitive workflows for neoantigen discovery and maintenance of
instrumentation. The role also involves managing independent research
projects, supervising junior researchers, and keeping up to date with latest
developments in the fields of immunopeptidomics and cancer vaccine research.
The applicant will join the T-cell Epitope Discovery Group led by Dr. Eleni
Adamopoulou, within the Centre for Immuno-Oncology directed by Professor
Timothy Elliott.
It is essential that you hold a PhD/DPhil in Chemistry, Biochemistry,
Immunology, Molecular Biology, or a related field, with hands-on experience
operating and maintaining Bruker and/or Thermo LC-MS/MS platforms. Proficiency
in data acquisition methods such as DDA, DIA, or PRM, and in data analysis
tools such as PEAKS, MSFragger, MaxQuant, Proteome Discoverer, or Skyline is
also required. The ability to manage multiple projects effectively along with
excellent interpersonal and communication skills and a collaborative mindset,
is essential. A working knowledge of immunology or a willingness to learn,
experience with quantitative mass spectrometry assays, and computational
skills including R or Python are highly desirable.
Applications for this vacancy should be made online and you will need to
upload a supporting statement and CV. Your supporting statement must explain
how you meet each of the selection criteria for the post using examples of
your skills and experience. Please restrict your documentation to your CV and
supporting statement only. Any other documents will be requested at a later
date.
This position is offered full time on a fixed term contract until 31 December
2027 and is funded by GSK.
Only applications received before 12 midday on 9 June 2025 will be considered.
Please quote **179719** on all correspondence.
Spectrometry-based Immunopeptidomics with a strong interest in cancer
immunology and innovative approaches for antigen discovery in cancer. You will
have hands-on experience with mass spectrometry-based proteomics, including
instrument operation, maintenance and data analysis workflows. You will
contribute to a research programme focused on deciphering the molecular
architecture of the HLA antigen processing and editing machinery, and
investigating how it shapes tumour-specific antigen presentation. Your project
will focus on identifying tumour-specific and immunogenic antigens from
primary tumour tissues using advanced immunopeptidomics approaches as part of
a multi-team initiative to design and deliver cancer-preventing vaccines
jointly led by the University of Oxford and GSK.
You will be responsible for LC-MS/MS data acquisition and analysis,
development of sensitive workflows for neoantigen discovery and maintenance of
instrumentation. The role also involves managing independent research
projects, supervising junior researchers, and keeping up to date with latest
developments in the fields of immunopeptidomics and cancer vaccine research.
The applicant will join the T-cell Epitope Discovery Group led by Dr. Eleni
Adamopoulou, within the Centre for Immuno-Oncology directed by Professor
Timothy Elliott.
It is essential that you hold a PhD/DPhil in Chemistry, Biochemistry,
Immunology, Molecular Biology, or a related field, with hands-on experience
operating and maintaining Bruker and/or Thermo LC-MS/MS platforms. Proficiency
in data acquisition methods such as DDA, DIA, or PRM, and in data analysis
tools such as PEAKS, MSFragger, MaxQuant, Proteome Discoverer, or Skyline is
also required. The ability to manage multiple projects effectively along with
excellent interpersonal and communication skills and a collaborative mindset,
is essential. A working knowledge of immunology or a willingness to learn,
experience with quantitative mass spectrometry assays, and computational
skills including R or Python are highly desirable.
Applications for this vacancy should be made online and you will need to
upload a supporting statement and CV. Your supporting statement must explain
how you meet each of the selection criteria for the post using examples of
your skills and experience. Please restrict your documentation to your CV and
supporting statement only. Any other documents will be requested at a later
date.
This position is offered full time on a fixed term contract until 31 December
2027 and is funded by GSK.
Only applications received before 12 midday on 9 June 2025 will be considered.
Please quote **179719** on all correspondence.
dc:spatial |
Oxford Centre for Immuno-Oncology, Old Road Campus Research Building, Roosevelt Drive, Headington, Oxford, OX3 7DQ
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vacancy:applicationClosingDate |
2025-06-09 12:00:00+01:00
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vacancy:applicationOpeningDate |
2025-05-19 09:00:00+01:00
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vacancy:furtherParticulars | |
vacancy:internalApplicationsOnly |
False
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comment |
We are seeking to appoint a highly motivated Senior Research Scientist in Mass Spectrometry-based Immunopeptidomics with a strong interest in cancer immunology and innovative approaches for antigen discovery in cancer. You will have hands-on experience with mass spectrometry-based proteomics, including instrument operation, maintenance and data analysis workflows. You will contribute to a research programme focused on deciphering the molecular architecture of the HLA antigen processing and editing machinery, and investigating how it shapes tumour-specific antigen presentation. Your project will focus on identifying tumour-specific and immunogenic antigens from primary tumour tissues using advanced immunopeptidomics approaches as part of a multi-team initiative ... We are seeking to appoint a highly motivated Senior Research Scientist in Mass
Spectrometry-based Immunopeptidomics with a strong interest in cancer immunology and innovative approaches for antigen discovery in cancer. You will have hands-on experience with mass spectrometry-based proteomics, including instrument operation, maintenance and data analysis workflows. You will contribute to a research programme focused on deciphering the molecular architecture of the HLA antigen processing and editing machinery, and investigating how it shapes tumour-specific antigen presentation. Your project will focus on identifying tumour-specific and immunogenic antigens from primary tumour tissues using advanced immunopeptidomics approaches as part of a multi-team initiative ... |
label |
Senior Research Scientist in Mass Spectrometry-based Immunopeptidomics
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notation |
179719
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based near | |
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