Postdoctoral Researcher– Therapeutic Resistance in Brain Cancer

**About the role**





We are seeking a highly motivated and ambitious Postdoctoral Researcher to
join our team in addressing a key question in cancer biology: why brain cancer
cells resist current therapies. This role offers a unique opportunity to
investigate the mechanisms of therapeutic resistance in glioblastoma and
contribute to the development of more effective treatment strategies.



Our research focuses on understanding how tumour cell plasticity and dynamic
cell state transitions drive resistance, and aims to identify actionable
vulnerabilities that could inform future therapies. You will work with
cutting-edge models and technologies—including patient-derived glioblastoma
organoids, CRISPR-based screens, mass cytometry, and advanced microscopy—to
dissect these complex biological processes.



You will be responsible for managing your own academic research, collaborating
with computational and clinical researchers, and contributing to the
scientific development of the lab. This is an exciting opportunity for a
researcher passionate about translational cancer research and making a
meaningful impact in the field.





**About you**





You will hold a PhD (or be close to completion) in a relevant field such as
cancer biology, molecular biology, medicine, or neuroscience. Your expertise
will include molecular biology techniques, advanced microscopy, quantitative
image analysis, and primary tissue culture, all of which will support your
contributions to high-quality, translational cancer research.



You will have a strong track record of research excellence, including first-
author publications in peer-reviewed journals, and demonstrate the ability to
manage complex projects, analyse large datasets, and deliver results to tight
deadlines. Your collaborative mindset and excellent communication skills will
enable you to work effectively within an interdisciplinary team and present
your findings confidently to both academic and clinical audiences.



Experience or interest in applying interdisciplinary approaches and additional
expertise in areas such as FACS/mass cytometry, bioinformatics, or in vivo
work (holding a personal licence) would be advantageous.





**Application Process**





If you would like to discuss this role, please contact Dr Lucy Brooks at
lucy.brooks@oncology.ox.ac.uk . You will be required to upload a supporting
statement (setting out how you meet the selection criteria), a curriculum
vitae, and the names and contact details of two referees as part of your
online application.





The closing date for applications is **noon** on **Monday, 16th June 2025.**





**What We Offer**





As an employer, we genuinely care about our employees' wellbeing and this is
reflected in the range of benefits that we offer including:



• An excellent contributory pension scheme



• 38 days annual leave



• A comprehensive range of childcare services



• Family leave schemes



• Cycle loan scheme



• Discounted bus travel and Season Ticket travel loans



• Membership to a variety of social and sports clubs





**Committed to equality and valuing diversity**