All vacancies within Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS)

There are currently 15 vacancies within Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS):

Title	Closes	Salary
Postdoctoral Research Associate	Feb. 18, 2019, noon	Grade 7: Salary in the range £32,236 - £37,345 p.a.
Research Radiographer Specialist	Feb. 27, 2019, noon	Grade 7: Salary in the range £32,236 - £37,345 p.a..
GCP Compliance and Quality Assurance Manager	Feb. 28, 2019, noon	Grade 8: £40,792 - £48,677 p.a.
Clinical Trial Manager	March 4, 2019, noon	Grade 7: £32,236 - £39,609 p.a.
Medical Statistician	March 4, 2019, noon	Grade 6: £28,660 - £34,189 p.a.
Postdoctoral Research Associate in Immunometabolism	March 4, 2019, noon	Grade 7: £32,236 - £39,609 p.a.
Postdoctoral Research Associate in Mixed Methods Research (maternity cover)	March 4, 2019, noon	Grade 7: £32,236 - £39,609 p.a.
Research Assistant in Statistics and Data Science	March 4, 2019, noon	Grade 6: £28,660 - £34,189 p.a.
Postdoctoral Research Associate in Statistical Genetics	March 8, 2019, noon	Grade 7: £32,236 - £39,609 p.a.
Bioinformatician in Microbiome Science	March 13, 2019, noon	Grade 7: £32,236 - £39,609 p.a.
Postdoctoral Research Assistant - Analysis of Human Motion with Ultrasound.	March 13, 2019, noon	Grade 7: Salary in the range £32,236 - £35,211 p.a.
Systematic Reviewer (Health Technology Assessment)	March 15, 2019, noon	Grade 7: £32,236 - £39,609 p.a.
Systematic Reviewer (Health Technology Assessment)	March 15, 2019, noon	Grade 6: £28,660 - £34,189 p.a.
Postdoctoral Research Assistant in Stem Cell and Cancer Research	March 18, 2019, noon	Grade 7: £32,236 - £39,609 p.a.
Postdoctoral Researcher in Computational Modelling for Tendon Tissue Engineering	March 18, 2019, noon	Grade 7: £32,236 - £39,609 p.a.

Postdoctoral Research Associate

Closes: Feb. 18, 2019, noon; salary: Grade 7: Salary in the range £32,236 - £37,345 p.a.

<div> We are seeking to recruit a talented, proactive Postdoctoral Research Associate to join Dr Gillian Farnie in NDORMS and the Structural Genomics Consortium, based at the Botnar Research Centre, Oxford. Within this initial short appointment you will work in an exciting collaborative environment to develop and establish cell based assays investigate novel chemical probes (generated by the SGC). This post will specifically develop a multi-cellular breast cancer model to investigate the effect of cancer associated fibroblasts on the response of tumour cells (cancer stem cells vs non CSC populations) to current clinical therapies. Using fluorescent tags and label retaining dyes each population can be monitored through high content screening and assay endpoints will include; proliferation, number of CSCs, DNA double stand breaks. The assay will be used to screen novel probes developed by the SGC (https://thesgc.org/chemical-probes). We anticipate the data generated during this short contract would lead to future grant application to investigate our findings in more detail. The postdoc appointed would be encourage to be in involved in grant writing and ideas for future proposals. Candidates should have experience in cell biology, molecular biology and practical experience innovating cell based assays would be desirable. You will be a self-motivated, skilful scientist with a strong academic track record and communication skills. This is a full-time fixed-term appointment until 29 February 2020. You will be required to upload a supporting statement and CV as part of your online application. The closing date for applications is 12.00 noon on 18 February 2019. </div>

Research Radiographer Specialist

Closes: Feb. 27, 2019, noon; salary: Grade 7: Salary in the range £32,236 - £37,345 p.a..

<div> We are seeking a research radiographer specialist to join our research team, working under the supervision of Professor Sion-Glyn Jones and Mrs Gail Lang at the Botnar Research Centre and Nuffield Orthopaedic Centre, Oxford. As Research Radiographer Specialist you will facilitate and enhance clinical research within the University and NHS. You will work closely with the Musculoskeletal TV SM Local Research Network Steering Group and Research Manager in planning current and future projects involving radiological imaging whilst undertaking the imaging requirements of NIHR portfolio studies, with a focus on MRI and ultrasound projects. As radiology operational lead within the team for NIHR portfolio research patients you will set and maintain the highest standards of imaging and patient care, undertake the imaging aspects of NIHR portfolio studies and train NOC radiographers and other clinical staff to do so if required. You will develop protocols and standards in relation to research, ensuring IR (ME)R and IRR compliance at all time as well as calibrate and undertake quality assurance programmes on highly specialist complex equipment for NIHR portfolio research studies. You will be HCPC registered, qualified at degree level with proven X-ray, MRI and/or ultrasound experience and be able to demonstrate current CPD portfolio. You will be able to demonstrate capability of working flexibly, independently and without direct supervision and will be willing to travel to other sites within the UK and Europe if required for specific studies. Experience of working within a Clinical Trials Unit or clinical research environment and a full UK driving licence would be desirable. This is a full-time fixed-term appointment until 31 March 2020. You will be required to upload a supporting statement and CV as part of your online application. The closing date for this position is 12.00 noon on Wednesday 27 February 2019. </div>

GCP Compliance and Quality Assurance Manager

Closes: Feb. 28, 2019, noon; salary: Grade 8: £40,792 - £48,677 p.a.

<div> We have an exciting opportunity for a full-time vacancy for a suitable candidate to fulfil a challenging and rewarding role with the Quality Assurance Team of the Oxford Clinical Trials Research Unit (OCTRU). OCTRU is one of 51 UKCRC registered Clinical Trials Units that runs all phases of clinical trials across multiple areas of medicine. The OCTRU office is based at the Botnar Research Centre in Headington, Oxford which forms part of the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS). As GCP Compliance and Quality Assurance Manager, you will be responsible for ensuring that OCTRUs QA team undertakes routine audits and central monitoring activities on internal systems which are integral to the quality of trial activities with the ultimate aim to have continual improvement and compliance with requirements on the growing portfolio of complex trials under the direction of the OCTRUs Head of Regulatory Affairs and Quality Assurance. You will also help support with the audit of Standard Operating Procedures (SOPs) and to ensure review of policies and SOPs in a timely manner. You will have a degree in a biomedical or related sciences subject, or other relevant qualification, whilst having significant experience of working with GCP and supporting documents. Considerable experience of monitoring and/or auditing clinical trial activities for compliance with GCP and clinical trial legislation and report writing is also essential, as is having critical and intelligent attention to detail and high standards of accuracy. A diploma in Quality Assurance or equivalent and membership of a QA Professional group such as RQA (formally known as BARQA) would be desirable, as would familiarity with ISO 9000:2000; ISO 9001. This is a full-time fixed-term appointment for 2 years. A lower grade offer may be made (Grade 7: £32,236 - £39,609 p.a.) with commensurate reduction in responsibilities if a suitable candidate cannot be found to fill the Grade 8 position You will be required to upload a supporting statement and CV as part of your online application. For informal enquiries, please contact Dr Joanna Black on 01865 572396 or email: <a rel="nofollow" href="mailto:joanna.black@ndorms.ox.ac.uk">joanna.black@ndorms.ox.ac.uk</a>. The closing date for this position is 12.00 noon on Thursday 28 February 2019. Interviews are expected to be held on Wednesday 13 March 2019. </div>

Clinical Trial Manager

Closes: March 4, 2019, noon; salary: Grade 7: £32,236 - £39,609 p.a.

<div> We have an exciting opportunity for a Clinical Trial Manager to join the Oxford Trauma group at the Kadoorie Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS), to be based at John Radcliffe Hospital, Oxford. As a Clinical Trial Manager you will take overall responsibility for the day-to-day management of one or more clinical trials. You will assist in finalising the protocol, study materials, training packages for collaborating sites and prepare trial specific instructions. You will also oversee data entry on the computer database (assisted by a Data Entry Clerk) and perform regular systematic checks of information held on trial database as required and you will act as a resource, providing advice and support to colleagues both internal and external to Oxford Trauma Group to promote good research practice. You will hold a degree in a biomedical or associated subject, or other relevant qualification, or proven experience in clinical research. Understanding of clinical research methodology, good clinical practice and the research governance framework as well as an experience and understanding of techniques for the management of medical research information e.g. data coding, entry validation and reporting are essential. Previous experience as a trial coordinator/manager and experience of overseeing the conduct of large clinical trials and working to a high standard of Good Clinical Practice would be desirable. This is a full-time fixed-term appointment until 31 October 2020. A lower grade offer may be made (Grade 6: £28,660 - £34,189 p.a.) with commensurate reduction in responsibilities (and amendment in job title to Clinical Trial Coordinator) if a suitable candidate cannot be found to fill the Grade 7 position. You will be required to upload a CV and supporting statement as part of your online application. The closing date for this position is 12.00 noon on Thursday 4 March 2019. </div>

Medical Statistician

Closes: March 4, 2019, noon; salary: Grade 6: £28,660 - £34,189 p.a.

<div> An exciting opportunity has arisen for a Medical Statistician to join the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS) based at The Botnar Research Centre, Oxford. You will contribute to the design, conduct, analysis and presentation of results of collaborative clinical research projects, mostly randomised clinical trials within Oxford Clinical Trials Research Unit (OCTRU) and the Centre for Statistics in Medicine (CSM). As a Medical Statistician you will assist in the design and set up of clinical research projects within a multidisciplinary team, prepare statistical analysis plans (SAP) and provide written statistical input into protocols and ethics committee submissions, and undertake both - interim and final analyses. You will attend and occasionally contribute to OCTRU/Centre for Statistics in Medicine activities such as seminars, conferences, workshops etc. All statisticians within the department also have the opportunities to participate in methodological work. You will have a postgraduate degree in statistics (or closely related subject), a substantial part of which relates to medical statistics, or equivalent experience. You will be fluent with key aspects of study design and analysis and aware of the latest statistical techniques. You will have good project management skills including the ability to manage and prioritise short and long term projects. Proficient knowledge of statistical software (Stata, SAS or R) as well as good verbal and written communications skills are also essential. Proficiency in statistical programming and experience of producing statistical reports and contributing to peer-review publications are desirable. This is a full-time fixed-term appointment for 2 years in the first instance. You must upload a CV and supporting statement as part of your online application. For informal queries please contact Susan Dutton on 01865 223451 or susan.dutton@csm.ox.ac.uk. The closing date for this position is 12.00 noon on Monday 4 March 2019 with interviews expected to be held on 15 March 2019. </div>

Postdoctoral Research Associate in Immunometabolism

Closes: March 4, 2019, noon; salary: Grade 7: £32,236 - £39,609 p.a.

<div> We are seeking a highly motivated and proactive Postdoctoral Researcher to join the research group of Dr Alexander Clarke at the University of Oxford. In this translational medicine project, you will analyse T cell metabolism in human and model autoimmune disease using state of the art techniques, to identify novel targets and understand how pathways already identified in the lab can be brought forward as potential therapies. You will be based at the world-famous Kennedy Institute of Rheumatology, University of Oxford, which provides outstanding support facilities, an intellectually stimulating environment, and carries out world-class research in the fields of immunology, autoimmunity, inflammation, tissue regeneration, with a long term objective of translating this research into clinical application. You will hold a relevant PhD/DPhil, together with relevant experience in standard techniques of immunology. You will also have a demonstrable track record in immunology, evidenced by first author publications in high quality, peer-reviewed journals with the ability to manage your own academic research and associated activities. Excellent communication skills are essential, including the ability to write for publication, present research proposals and results, and represent the research group at meetings, evidenced by presentations at national and international scientific meetings. Experience and expertise in T cell immunology and metabolomics would be desirable. Owing to the nature of this position, any offer of employment with the University will be subject to a satisfactory basic Disclosure and Barring Service check and University security screening (eg identity checks). This is a full-time appointment fixed-term for 2 years in the first instance. You will be required to upload a supporting statement, CV and names of referees as part of your online application. The closing date for applications is 12.00 noon on Monday 4 March 2019. </div>

Postdoctoral Research Associate in Mixed Methods Research (maternity cover)

Closes: March 4, 2019, noon; salary: Grade 7: £32,236 - £39,609 p.a.

<div> We have an exciting opportunity for a Postdoctoral Research Associate in Mixed Methods Research to contribute to the work of the Oxford Trauma Research team at the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, to be based at the Kadoorie Critical Care Research Centre, John Radcliffe Hospital, Oxford. As a Postdoctoral Research Associate in Mixed Methods Research you will work to recruit and consent participants into the qualitative aspects of the SCIENCE and STIFF-F studies. You will undertake interviews and focus groups, analyse qualitative data and make links to quantitative data from a variety of sources as appropriate as well as prepare manuscripts from the research study for publication in high quality journals. You will have a PhD (or be close to completion) in health, psychology, sociology, or public health sciences and experience in the conduct and analysis of qualitative research. Knowledge of quantitative research techniques and a proven ability to develop and deliver high quality research as well as a record of actual/planned publications in high quality journals are essential. You must have excellent communication, organisational and presentation skills and the ability to work independently and as part of a team to manage own academic research activities. Experience of complex intervention research and experience of working in an academic research environment would be desirable. This is a full-time fixed-term (maternity cover) appointment for 12 months. Owing to the nature of the research at the Kadoorie Centre, this job will require additional security pre-employment checks: a satisfactory enhanced Disclosure and Barring Service check. You will be required to upload a CV and supporting statement as part of your application. The closing date for applications is 12.00 midday on Monday 4 March 2019. The interview will take place at the Kadoorie Centre, John Radcliffe Hospital on 12 March 2019. </div>

Research Assistant in Statistics and Data Science

Closes: March 4, 2019, noon; salary: Grade 6: £28,660 - £34,189 p.a.

<div> We are seeking to recruit an enthusiastic and highly organised individual for the role of Research Assistant in Statistics and Data Science, to work within the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences at the University of Oxford. You will be based at the Botnar Research Centre, Oxford. The NDORMS Musculoskeletal Pharmaco- and Device epidemiology research group is involved in a number of national and international studies exploring the conditions of use (adherence, compliance, off and on-label use) of a number of licensed drugs for the treatment of musculoskeletal conditions in 'real world' actual practice conditions. As a Research Assistant in Statistics and Data Science you will take a leading role in the statistical analysis of data from routinely collected data sources. You will contribute to existing and new research projects, including writing bids for research grants in collaboration with NHS and University staff. You will contribute to the development of innovative and creative methodologies and techniques and you will contribute to publications in peer-reviewed journals as a statistical/epidemiologist author. You must hold a postgraduate degree in statistics, health informatics, engineering, or data science. Experience in biostatistics, knowledge of medical statistics and expertise in handling large patient level datasets as well as an expertise in statistical analysis packages (preferably R) are essential. Expertise in machine learning, preferably in healthcare, Knowledge/experience of epidemiology and programming expertise in Python, Matlab, and experience in GIMP, Inkscape are desirable. This is a full-time, fixed-term appointment for 2 years. You will be required to upload a CV and supporting statement as part of your online application. The closing date for this position is 12.00 noon on Monday 4 March 2019. </div>

Postdoctoral Research Associate in Statistical Genetics

Closes: March 8, 2019, noon; salary: Grade 7: £32,236 - £39,609 p.a.

<div> We are seeking a Postdoctoral Research Scientist to study the genetics of inflammatory bowel disease (IBD) using statistical models and methods development. This post will be based at the Kennedy Institute of Rheumatology at NDORMS, University of Oxford. As part of a collaborative project to understand the impact of IBD risk genes on the human immune system, you will work closely with statistical geneticists and experimental immunologists to develop new analysis techniques for genetic data. You will develop and apply statistical methodology, machine learning algorithms and/or computational tools to produce new biological insights into the results of genome-wide association studies. You will be part of the community of the immunology-focused Kennedy Institute and the data science focused Big Data Institute. You will plan new studies with other team members, report regularly to the Group Head on scientific activities and any other issues that may influence the optimal running of the project and work independently and largely unsupervised. You will test hypotheses and analyse data from a variety of sources, reviewing and refining hypotheses as appropriate. Other duties will include maintaining records of all findings, sharing data with others, and supervising junior members of the lab. You must hold a PhD degree (or near completion) or equivalent in a quantitative science subject, with experience of, and proven research skills, in high-throughput genetics or related big healthcare or biomedical data. You will have programming skills in R, python or C++, or good knowledge of other languages and a willingness to learn others. You will have the ability to manage the day-to-day running of a research project, the capacity to deliver high-quality research outputs, good spoken and written communication skills. Experience developing new methods for genome-wide association studies or related data types is desirable. This is a full-time (part-time, minimum 60% FTE would be considered) position for 2 years. Owing to the nature of the research at the Kennedy Institute of Rheumatology, this job will require additional security pre-employment checks: a satisfactory basic Disclosure and Barring Service check The closing date for this position is 12.00 noon on Friday 8 March 2019. You will be required to upload a CV and supporting statement as part of your online application. </div>

Bioinformatician in Microbiome Science

Closes: March 13, 2019, noon; salary: Grade 7: £32,236 - £39,609 p.a.

<div> We are seeking a Bioinformatician to join Dr Nicholas Ilott and the Oxford Centre for Microbiome Studies (OCMS). The OCMS is a new Oxford initiative within the Kennedy Institute of Rheumatology, where you would be based and is overseen by Professor Fiona Powrie. It is designed to facilitate access to state-of-the art facilities and expertise for experimental research into the microbiome both for those new to the field and established groups. You will contribute to the study design of proposed projects to the OCMS and provide computational and statistical analysis for OCMS projects including analysis of high-throughput sequencing data in the context of host-microbiota and bacterial interactions. You will develop and establish pipelines for microbial analysis, and improve existing pipelines in collaboration and with other bioinfomaticians at the Kennedy. You will actively participate in meetings at group, institute and departmental level as well as maintaining an up-to-date awareness of relevant publications in the area of research. You must hold a PhD degree (or near completion) in a relevant subject such as bioinformatics or computational biology, applicants with a background in computer sciences augmented with extensive experience in life sciences would also be considered. You will have excellent programming skills in at least one programming language, preferably Python and/or R, as well as previous experience working with large datasets. Interest in microbiome research and experience working on collaborative projects is essential. Previous experience managing multiple projects and previous experience in the analysis of microbial communities is desirable. This is a full-time position for 2 years. Owing to the nature of the research at the Kennedy Institute of Rheumatology, this job will require additional security pre-employment checks (a satisfactory basic Disclosure and Barring Service check). You will be required to upload a CV and supporting statement as part of your online application. The closing date for this position is 12.00 noon on Wednesday 13 March 2019. </div>

Postdoctoral Research Assistant - Analysis of Human Motion with Ultrasound.

Closes: March 13, 2019, noon; salary: Grade 7: Salary in the range £32,236 - £35,211 p.a.

<div> We are seeking a full-time Postdoctoral Research Assistant to join the Oxford Orthopaedic Engineering Centre (OOEC) at the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences at the University of Oxford. The successful applicant will be part of an inter-disciplinary team of engineers and clinicians working on the research and development of a system for applications in clinical orthopaedics. You will work on a project that aims to rapidly combine data from motion capture with data from multiple ultrasound probes in order to reconstruct bony motion. In addition, you will develop and test software for a novel motion capture system for measuring joint motion and analyse data captured. You will also contribute documented software and system design documents to the project, write up the results for conference and journal publication and perform occasional demonstrations to industrial or academic visitors, assisting informally with the supervision of graduate students conducting related research. You will have a PhD (or be close to completion) in engineering, computer science, orthopaedic biomechanics, or a related technical field and experience of working with motion capture. You will have a demonstrated ability to program C/C++, Python and/or MATLAB to a high standard and competency in using different operating systems is essential. You must have excellent communication skills and also be willing to travel within and outside the UK to visit collaborating institutions. Experience in the analysis of ultrasound images, multi-modality data acquisition and fusion would be desirable. This is a full time fixed-term appointment for 1 year. You will be required to upload a supporting statement and CV as part of your online application. The closing date for applications is 12.00 noon on Wednesday 13 March 2019. </div>

Systematic Reviewer (Health Technology Assessment)

Closes: March 15, 2019, noon; salary: Grade 7: £32,236 - £39,609 p.a.

<div> We are seeking a lead Systematic Reviewer to join the (Knee Research Group) in Oxford which is part of the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS) based in the Botnar Research Centre, Oxford. The project is collaboration between the University of Oxford and the University of Warwick and is funded by the National Institute for Health Research Health Technology Assessment programme. This is an exciting opportunity to join a dynamic team of collaborators from a number of groups. As the lead Systematic Reviewer, you will conduct and deliver a series of high quality and high profile systematic reviews of the effectiveness of surgery for early osteoarthritis of the hip and knee joint in a timely fashion. You will present and discuss the project methodology with the research team and, where appropriate, adapt the methodology to align with the highest methodological rigor and the research teams advice. You will collaborate in the preparation of reports and articles, and present research results both internally and externally if required as well as act as a source of information and advice on systematic reviews to other members of the research group. You will be supported by the junior systematic reviewer, for whom you will be responsible for managing their day-to-day programme of work. You will hold a good first degree (first or upper class second) in a health related or scientific discipline. Demonstrable previous experience of delivering high quality systematic reviews and evidence of strong analytical skills is essential as is: strong IT literacy, excellent communication skills and an ability to work within multi-disciplinary teams and independently. A postgraduate degree (or equivalent professional experience in relevant field), previous line management experience and content expertise in the management of people with osteoarthritis are desirable. This is a full-time fixed-term appointment for 20 months. As the funding for this position starts from 1 June 2019 (NIHR), please note it would not be possible to start before this date. You will be required to upload a CV and supporting statement as part of your online application. The closing date for this position is 12.00 noon on Friday 15 March 2019. </div>

Systematic Reviewer (Health Technology Assessment)

Closes: March 15, 2019, noon; salary: Grade 6: £28,660 - £34,189 p.a.

<div> We are seeking a Systematic Reviewer to join the (Knee Research Group) in Oxford which is part of the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS) based in the Botnar Research Centre, Oxford. The project is collaboration between the University of Oxford and the University of Warwick and is funded by the National Institute for Health Research Health Technology Assessment programme. This is an exciting opportunity to join a dynamic team of collaborators from a number of groups. As a Systematic Reviewer, you will support the conduct and delivery of a series of high quality and high profile systematic reviews of the effectiveness of surgery for early osteoarthritis of the hip and knee joint in a timely fashion. You will work closely with the senior lead systematic reviewer and will co-present and discuss the project methodology with the research team and, where appropriate, adapt the methodology to align with the highest methodological rigor and the research teams advice. You will collaborate in the preparation of reports and articles, and present research results both internally and externally if required. You will hold a good first degree (first or upper class second) in a health related or scientific discipline. Demonstrable previous experience of delivering high quality systematic reviews and evidence of strong analytical skills is essential as is: strong IT literacy, excellent communication skills and an ability to work within multi-disciplinary teams and independently. A postgraduate degree (or equivalent professional experience in relevant field) and content expertise in the management of people with osteoarthritis are desirable. This is a full-time fixed-term appointment for 18 months. As the funding for this position starts from 1 June 2019 (NIHR), please note it would not be possible to start before this date. You will be required to upload a CV and supporting statement as part of your online application. The closing date for this position is 12.00 noon on Friday 15 March 2019. </div>

Postdoctoral Research Assistant in Stem Cell and Cancer Research

Closes: March 18, 2019, noon; salary: Grade 7: £32,236 - £39,609 p.a.

<div> An exciting opportunity has arisen for a Postdoctoral Research Assistant to join the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS) based at The Botnar Research Centre, Oxford. You will carry out postdoctoral research into the cell biology and biochemistry of TGFß signalling pathway in human pancreatic ductal adenocarcinomas and human pluripotent stem cells, working in the research group of Dr Siim Pauklin, and will utilise cutting-edge cell culture methods including cancer stem cell sphere systems and pancreatic organoids, and use a range of experimental methods: genome-wide techniques (RNA-seq, ChIP-seq, ATC-seq), proteomics (Co-IP / mass-spectrometry), CRISPR-mediated functional studies (overexpression/knockdown/knockout), in vitro mechanistic studies (promoter-luciferase studies, confocal microscopy, flow cytometry, western blotting), and in vivo tumorigenesis experiments in mice. As a Postdoctoral Research Assistant you will manage your own academic research and administrative activities, as well as carrying out collaborative projects with colleagues in partner institutions, and research groups. You will collaborate in the preparation of scientific reports and journal articles and occasionally present papers and posters. Your aim will be to make progress in the dedicated research area of human pancreatic ductal adenocarcinoma, human stem cell biology and pancreatic cancer stem cells. You will have a PhD/DPhil degree (or near completion) in cell biology, biochemistry, molecular biology, genetics, computational biology or related disciplines. You will have experience in stem cell biology and/or cancer research and the ability to carry out high-quality, cutting-edge research, along with at least one first author research paper. Experience in Western blotting, Real time PCR, Flow cytometry and Immunofluorescence microscopy and Cloning techniques for generating DNA constructs would be desirable. This is a full-time fixed-term appointment for 2 years in the first instance. You must upload a CV and supporting statement as part of your online application. The closing date for this position is 12.00 noon on Monday 18 March 2019. </div>

Postdoctoral Researcher in Computational Modelling for Tendon Tissue Engineering

Closes: March 18, 2019, noon; salary: Grade 7: £32,236 - £39,609 p.a.

<div> Applications are invited for the position of a Postdoctoral Researcher in Computational Modelling for Tendon Tissue Engineering to join an interdisciplinary team of researchers collaborating on a project led by Dr Mouthuy at the Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS), Oxford. This post will be included in the activities of the Carr group as well as Professor Jerusalems group at the Department of Engineering Science, Oxford and Professor Waters group at the Mathematical Institute, Oxford and as such the postholder will be required to work across these locations. As a Postdoctoral Researcher in Computational Modelling for Tendon Tissue Engineering you will participate in the activities of the research team in the Humanoid Bioreactor project, sharing skills and knowledge and publishing your findings in peer-reviewed journals. You will analyse, contextualise and interpret data, write and maintain programs and protocols for data analysis as well as train and supervise graduate and undergraduate students as appropriate. You will hold a PhD/DPhil (or near completion) in a discipline of direct relevance to computational mechanics and/or tissue engineering. You will be competent with programming languages such as C/C++ and Matlab as well as numerical simulations, model calibration and validation. You will have an experience in implementing mathematical descriptions of physical biological processes and you will be highly self-motivated and committed to pursuing interdisciplinary research. Experience with handling clinical imaging data such as CT, MRI or ultrasound scans, strong competences in the use of CAD software to design materials and an ability to conduct experiments with cells and biomaterials are desirable. This is a full-time fixed-term appointment for 3 years. You will be required to upload a CV and supporting statement as part of your online application. The closing date for this position is 12.00 noon on Monday 18 March 2019. </div>