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All vacancies within Nuffield Department of Clinical Neurosciences

There are currently 6 vacancies within Nuffield Department of Clinical Neurosciences:

Title Closes Salary
SENIOR CLINICAL RESEARCH FELLOW - PRIMARY CARE March 11, 2021, noon Grade: E66 £58,672-£72,824 pa
Research Associate in Functional Diagnostics for the Congenital Myasthenia highly specialised service March 12, 2021, noon Grade 7: £31,604 - £38,833 per annum
Postdoctoral Neuroscientist March 19, 2021, noon Grade 7: £32,817- £40,322 per annum
Post-doctoral Research Associate in Neuroscience March 26, 2021, noon Grade 7: £32,817-£40,322 per annum
Senior Postdoctoral Bioinformatician March 26, 2021, noon Grade 8: £41,526 - £49,553 per annum
Senior Postdoctoral Scientist March 26, 2021, noon Grade 8: £41,526 -£49,553 per annum.

SENIOR CLINICAL RESEARCH FELLOW - PRIMARY CARE

Closes: March 11, 2021, noon; salary: Grade: E66 £58,672-£72,824 pa

<div> <p></p><div>A part-time (equivalent to 2PAs/0.2wte) Senior Clinical Research Fellow is required to join a highly productive research team at the Wolfson Centre for the Prevention of Stroke and Dementia. (CPSD).&#160;&#160;The post holder will join a team who are working on a range of clinical projects and monitoring of time-trends in incidence and outcome of stroke, coronary events, and other vascular diseases.&#160;The successful applicant will focus their research on clinical epidemiology and the primary/secondary prevention of vascular disease in routine general practice, and the role will require up to date knowledge of management of vascular disease in the UK.&#160; Under the direction of Professor Peter Rothwell, the post holder will review previously published research and planning analyses of new data as well as analysis of data with assistance from CPSD statisticians.&#160; They will be expected to write up reports of CPSD research studies for publication and present results of CPSD research at national and international research meetings.</div><br> <div>&#160;</div><br> <div>The Wolfson Centre for the Prevention of Stroke and Dementia is located in the Wolfson Building on the John Radcliffe Hospital site and is part of the Nuffield Department of Clinical Neurosciences (NDCN). The main research interests are the prevention of stroke, hypertension, vascular dementia, and in the aetiology of vascular disease more generally. The unit currently comprises 30 researchers and support staff, including senior clinical researchers in neurology and geriatrics, clinical research fellows, statisticians and programmers, research nurses and laboratory scientists.</div><br> <div>&#160;</div><br> <div>It is essential that applicants be GMC and MRCGP registered with a licence to practice in the UK. They should also have excellent organisational and communication skills, be able to write concisely, coherently and logically, and have computing experience in Windows, MS Office, Access, Excel, Microsoft Word and SPSS or equivalent statistical software.&#160; The post holder will&#160; be experienced in the diagnosis and treatment of patients with vascular disease, postgraduate research experience and an established research interest in the clinical epidemiology of vascular disease.&#160; They should be a methodical worker, have the ability to use their initiative, be highly motivated and be able to work effectively as part of a team.&#160; A higher degree (DPhil/PhD/Md/MPH) would also be desirable.</div><br> <div>&#160;</div><br> <div>&#160;</div><br> <div>The post is part-time and fixed-term until 31st August 2022</div><br> <div>&#160;</div><br> <div>Only applications received before 12:00 midday on Thursday&#160;11th March 2021 will be considered.</div><br> <div>&#160;</div><br> <div>Interviews will be held as soon as possible thereafter.</div> </div>

Research Associate in Functional Diagnostics for the Congenital Myasthenia highly specialised service

Closes: March 12, 2021, noon; salary: Grade 7: £31,604 - £38,833 per annum

<div> <p></p><div>THIS VACANCY IS FOR INTERNAL APPLICANTS ONLY</div><br> <div>&#160;</div><br> <div>We are seeking a highly motivated Research Associate in Functional Diagnostics for the Congenital Myasthenia highly specialised service to join the Nuffield Department of Clinical Neurosciences (NDCN). This post is to cover the absence of the substantive post holder, who is taking a period of maternity leave.</div><br> <div>&#160;</div><br> <div>Reporting to Professor David Beeson, you will be expected to collate DNA samples for the highly specialised service for congenital myasthenic syndromes based in Oxford. You will be responsible for liaising with the clinical genetics laboratory and the clinical team over samples requiring analysis. You will also be required to perform functional analysis on variants of unknown significance within the genes that are known to cause congenital myasthenic syndrome.</div><br> <div>&#160;</div><br> <div>It is essential that you have expertise in all aspects of molecular biology including mutagenesis, cell culture, plasmid construction, fluorescent microscopy, transfections, immunohistochemistry, DNA sequence analysis and PCR. Knowledge of radioactive bungarotoxin cell-surface binding assays and retroviral transfection and differentiation of muscle cells is also essential. Experience in preparing samples for electron microscopy is desirable.</div><br> <div>&#160;</div><br> <div><strong>The post is part time (0.8 FTE) and fixed-term until 4th January 2022 in the first instance.</strong></div><br> <div>&#160;</div><br> <div><strong>Only applications received before 12.00 midday on 12th March 2021 will be considered.</strong></div><br> <div>&#160;</div><br> <div><strong>Interviews will be held as soon as possible thereafter.</strong></div><br> <div>&#160;</div> </div>

Postdoctoral Neuroscientist

Closes: March 19, 2021, noon; salary: Grade 7: £32,817- £40,322 per annum

<div> <p></p><div>We are looking for a Postdoctoral Neuroscientist to work on an exciting opportunity which will involve a collaborative project between Astra Zeneca and the neural injury group, NDCN. Under the supervision of Prof Bennett and Dr McDermott, the postholder will aim to develop a human cellular model of chemotherapy induced neuropathy (using sensory neurons differentiated from induced pluripotent stem cells) and then to test the recently described molecular mediators of Wallerian degeneration such as NMNAT2 and dSARM in this pathway in these outcomes.</div><br> <div>&#160;</div><br> <div>The post will therefore suit an applicant who has an interest in the response to neural injury, the Wallerian degeneration pathways and translational neuroscience. The neural injury group consists of a multi-disciplinary team ranging with expertise ranging from molecular neurobiology to clinical phenotyping. This post will provide training and expertise in the use of human induced pluripotent stem cells as disease models, microfluidic cell culture, assessments of: axon transport, calcium imaging and excitability. The post is primarily be based in NDCN, but there will be meetings and collaborative opportunities with Astra Zeneca providing a useful perspective from the pharmaceutical industry.</div><br> <div>&#160;</div><br> <div>The successful candidate will hold a Ph.D. or M.D. or equivalent qualification in a relevant area of biological research/biomedical engineering. The qualification can be held (appointed to Grade 7) or submitted for examination/ nearing completion (appointed to Grade 6) by the time of starting the post. The candidate selected will also have essential experience of designing and executing experiments involving cultures neurons including functional (calcium imaging and/or electrophysiology) and morphological outcomes. It is also essential that the candidate has expertise in the detailed analysis and interpretation of functional outcomes in cellular models such as axon transport, calcium imaging and electrophysiology.</div><br> <div>&#160;</div><br> <div>This is a Grade 7 position, but applicants with less experience are also invited to apply as a Grade 6 appointment.</div><br> <div>&#160;</div><br> <div><strong>The post is full-time for a fixed term, until the 3rd January 2023, in the first instance.</strong></div><br> <div><strong>Only applications received before 12.00 midday on 19th March 2021 will be considered.</strong></div><br> <div><strong>Interviews will be held as soon as possible thereafter.</strong></div><br> <div>&#160;</div> </div>

Post-doctoral Research Associate in Neuroscience

Closes: March 26, 2021, noon; salary: Grade 7: £32,817-£40,322 per annum

<div> <p></p><div>We are looking for a well-trained and enthusiastic individual to join our group on a new and exciting drug discovery project aimed to develop novel therapeutics for spinocerebellar ataxia (SCA). The project is funded by LifeArc and will be carried out in collaboration with medicinal chemists in the group of Professor Paul Brennan at the Centre for Medicines Discovery at the University of Oxford.</div><br> <div>Your duties will include working independently and contributing conceptually to the project and co-ordinating multiple aspects of the work to meet deadlines. You will also establish and optimise protocols, in addition to designing and accurately executing experiments. The successful candidate will be responsible for keeping accurate records of activity and carrying out data analysis and statistics. Another aspect of the role will be to communicate progress effectively with the Principle Investigator, the group and collaborators.</div><br> <div>&#160;</div><br> <div>It is essential that those applying for the role hold, or are nearing completion of a PhD/DPhil in a relevant discipline - or are clinically qualified. It is also essential that applicants have expertise in electrophysiology, and experience in data analysis and statistics. It is desirable if candidates have expertise in cerebellar biology.</div><br> <div><strong>The post is full-time and fixed-term until the 31st December 2023 in the first instance.</strong></div><br> <div><strong>Only applications received before 12.00 midday on 26th March 2021 will be considered.</strong></div><br> <div><strong>Interviews will be held as soon as possible thereafter.</strong></div> </div>

Senior Postdoctoral Bioinformatician

Closes: March 26, 2021, noon; salary: Grade 8: £41,526 - £49,553 per annum

<div> <p></p><div>An exciting opportunity to join a collaborative multiple sclerosis research project at the John Radcliffe Hospital, University of Oxford.</div><br> <div>&#160;</div><br> <div>You are invited to apply to join Professor Lars Fugger and his team at the Oxford Centre for Neuroinflammation (OCNI), as part of the Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, UK, in collaboration with Professor Gil McVean, Big Data Institute.</div><br> <div>&#160;</div><br> <div>Multiple sclerosis (MS) is the most common, chronic disabling neurological condition in young adults, afflicting more than 2.5 million people worldwide, with a strong gender bias towards women. The unmet challenge to prevent disease progression in patients with multiple sclerosis (MS) indicates that current treatment options are constrained by our understanding of disease causality and the pathways or cell types that become engaged at both onset and throughout disease course. Innovative strategies, utilizing the recent advances in experimental and computational models, aim to provide a refreshed outlook on the fuel that drives neuroinflammatory processes and to develop better treatments for patients.</div><br> <div>&#160;</div><br> <div>The successful candidate will be hold or be nearing completion a Ph.D/D.Phil in a relevant scientific subject. They will join part of a research initiative that will use single-cell multi-omics technologies and to apply these to MS patient and control samples. You must be highly motivated and have the ability to develop new ideas and analytical methods. A strong background in analysing single-cell and GWAS datasets is desirable.</div><br> <div>&#160;</div><br> <div>If you would like to discuss this position informally before applying, please email Professor Fugger (lars.fugger@imm.ox.ac.uk ). This is a Grade 8 position, but applicants with less experience are also invited to apply as a Grade 7 appointment.</div><br> <div>&#160;</div><br> <div>Further information regarding the research group of Professors Lars Fugger can be found at: www.ocni.co.uk</div><br> <div>&#160;</div><br> <div><strong>The post is full-time and fixed until the 31st March 2022 in the first instance.</strong></div><br> <div><strong>Only applications received before 12.00 midday on 26th March 2021 will be considered.</strong></div><br> <div><strong>Interviews will be held as soon as possible thereafter.</strong>&#160;</div><br> <div>&#160;</div> </div>

Senior Postdoctoral Scientist

Closes: March 26, 2021, noon; salary: Grade 8: £41,526 -£49,553 per annum.

<div> <p></p><div>An exciting opportunity to join a collaborative multiple sclerosis research project at the John Radcliffe hospital, University of Oxford.</div><br> <div>&#160;</div><br> <div>You are invited to apply to join Professor Lars Fugger and his team at the Oxford Centre for Neuroinflammation (OCNI), as part of the Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, UK. You will lead a collaborative research project between Professor Lars Fugger, Dr Kate Attfield (also part of the OCNI team) and Bristol Myers Squibb (Celgene), to explore and develop new treatment options for multiple sclerosis patients.</div><br> <div>&#160;</div><br> <div>Multiple sclerosis (MS) is the most common, chronic disabling neurological condition in young adults, afflicting more than 2.5 million people worldwide, with a strong gender bias towards women. The unmet challenge to prevent disease progression in patients with multiple sclerosis (MS) indicates that current treatment options are constrained by our understanding of disease causality and the pathways or cell types that become engaged at both onset and throughout disease course. Innovative strategies, utilizing the recent advances in experimental and computational models, aim to provide a refreshed outlook on the fuel that drives neuroinflammatory processes and to develop better treatments for patients.</div><br> <div>&#160;</div><br> <div>The successful candidate will hold or be nearing completion a Ph.D/D.Phil with post-qualification research experience in immunology/neuroimmunology. They will join part of a research initiative that will use single-cell technologies, MS patient samples, genotype-specific recruitment of healthy volunteer blood samples and in vivo modelling.</div><br> <div>You must be highly motivated and have the ability to develop new ideas and research objectives. A strong background in human immunology or neuroimmunology is essential, with experience with primary cell handling and culture. Experience in functional genomics technologies is desirable.</div><br> <div>&#160;</div><br> <div>If you would like to discuss this position informally before applying, please email Professor Fugger (lars.fugger@imm.ox.ac.uk ) or Dr Kate Attfield (kate.attfield@ndcn.ox.ac.uk ). This is a Grade 8 position, but applicants with less experience are also invited to apply as a Grade 7 appointment.</div><br> <div>&#160;</div><br> <div>Further information regarding the research group of Professors Lars Fugger can be found at: https://www.ocni.co.uk/</div><br> <div>&#160;</div><br> <div><strong>The post is full-time and fixed-term until 31st October 2023 in the first instance.</strong></div><br> <div><strong>Only applications received before 12.00 midday on Friday 26thMarch 2021 will be considered.</strong></div><br> <div><strong>Interviews will be held as soon as possible thereafter.</strong></div><br> <div>&#160;</div> </div>