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All vacancies within Nuffield Department of Clinical Neurosciences
There are currently 4 vacancies within Nuffield Department of Clinical Neurosciences:
| Title | Closes | Salary |
|---|---|---|
| Research Assistant In Extracellular Vesicle Biomarkers | April 25, 2025, noon | Research Grade 6: £34,982 - £40,855 per annum |
| Postdoctoral Researcher | April 28, 2025, noon | Research Grade 7: £38,674 - £46,913 |
| Postdoctoral Research Scientist | May 14, 2025, noon | Research Grade 7: £38,674 - £46,913 |
| Postdoctoral Research Associate | May 21, 2025, noon | Research Grade 7: £38,674 – £46,913 per annum A less experienced candidate may be appointed at Research Grade 6 (£34,982 to £40,855) per annum, with a commensurate adjustment in either the essential criteria, responsibilities or duties. |
Research Assistant In Extracellular Vesicle Biomarkers
Closes: April 25, 2025, noon; salary: Research Grade 6: £34,982 - £40,855 per annum
<div> <p></p><div>We are seeking an ambitious and highly motivated <strong>Research Assistant</strong> to work in a programme of research that aims to investigate extracellular vesicle biogenesis and biomarkers in Parkinson’s disease. The study will involve the use of iPSC-based models to elucidate molecular mechanisms and biosamples from patient cohorts to validate biomarkers. As such, the post will offer an excellent opportunity for mechanistic and translational research using state-of-the-art models and facilities available at the Kavli Institute for Nanoscience Discovery and Nuffield Department of Clinical Neurosciences at the University of Oxford. The position is ideal for a research assistant that wishes to pursue a DPhil. The post-holder with also benefit from and be exposed to interactions with Industry and work alongside a multidisciplinary team in the Molecular Neurodegeneration Research Group. For details check the lab website at: https://www.ndcn.ox.ac.uk/research/molecular-neurodegeneration-research-group</div><br> <div> </div><br> <div><strong>This post is full time and fixed term for 2 years in the first instance.</strong></div><br> <div> </div><br> <div><strong>Only applications received before midday 12:00 on Friday 25th April 2025 will be considered. </strong></div><br> <div> </div><br> <div><strong>Interviews will be held as soon as possible thereafter.</strong></div> </div>Postdoctoral Researcher
Closes: April 28, 2025, noon; salary: Research Grade 7: £38,674 - £46,913
<div> <p></p><div>We are seeking a <strong>Postdoctoral Research Assistant</strong> to run exercise studies on healthy volunteers and on patients with breathing difficulties.  We are using immersive virtual reality to manipulate the cycling experience.  The post is based in Oxford, and would be suitable for someone who is happy to be physically present in the laboratory for most of the week. The studies are a continuation of those described in this manuscript: <a rel="nofollow" href="http://">https://www.biorxiv.org/content/10.1101/2022.06.16.496494v1 </a></div><br> <div> </div><br> <div>Your duties will include managing your own research, running research experiments, contributing to the design of research materials and analysing and presenting qualitative and/or quantitative data from a variety of sources.</div><br> <div> </div><br> <div>The successful candidate will hold a PhD degree in a relevant topic (e.g. Biomedical sciences), have good organisational and communication skills and have experience running research studies in humans. Experience with data analysis and basic experience using programming languages (e.g. R, Python, Unity, Matlab) is desirable.</div><br> <div> </div><br> <div>Potential applicants are very welcome to discuss the role with Kyle Pattinson, the PI at <a rel="nofollow" href="http://">kyle.pattinson@nda.ox.ac.uk </a></div><br> <div> </div><br> <div><strong>The post is full time for a fixed term of 12 months in the first instance.</strong></div><br> <div> </div><br> <div><strong>Only applications received before 12.00 midday on Monday 28th April will be considered. </strong></div><br> <div> </div><br> <div><strong>Interviews will be held Wednesday 21st May. </strong></div> </div>Postdoctoral Research Scientist
Closes: May 14, 2025, noon; salary: Research Grade 7: £38,674 - £46,913
<div> <p></p><div> </div><br> <div>AN EXCITING OPPORTUNITY TO JOIN A MULTIDISCIPLINARY RESEARCH TEAM AT THE OXFORD CENTRE FOR NEUROINFLAMMATION</div><br> <div> </div><br> <div>You are invited to apply to join Professor Lars Fugger and his team at the University of Oxford, based at the Weatherall Institute of Molecular Medicine, John Radcliffe Hospital. You will join a team of research scientists, computational biologists, and clinicians, have access to state-of-the-art technologies and collaborate with leading researchers both locally and globally.</div><br> <div> </div><br> <div>Physical and mental disability caused by the immune system is a common clinical occurrence in many diseases of the brain, most notably for patients with multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD) and MOG antibody disease (MOGAD). However, the role of immune cells in patients afflicted by these diseases is largely unknown, thereby limiting our ability to develop better and safer treatment options. As part of a highly collaborative research initiative, the successful applicant will perform a diverse range of experimental assays that rely on a strong understanding of cellular and molecular biology.</div><br> <div> </div><br> <div>Applicants must hold a PhD/ D.Phil in Immunology or Neuroimmunology. You must have experience working with primary cells and/or patient tissue and be highly motivated to learn and develop new techniques that interrogate the function of cells in a disease setting.</div><br> <div> </div><br> <div>Please see the below 'Job Description' for further details on the responsibilities and selection criteria, as well as further information about the university and how to apply.</div><br> <div> </div><br> <div>This is a highly competitive position and therefore it is advisable to contact Professor Lars Fugger prior to making a formal application in order to discuss the role. If you would like to discuss your application informally before applying, please email Professor Fugger ( <a rel="nofollow" href="http://">lars.fugger@ndcn.ox.ac.uk</a>).</div><br> <div> </div><br> <div><strong>The post is full time for a fixed term of 3 years in the first instance.</strong></div><br> <div> </div><br> <div><strong>Only applications received before 12.00 midday on Wednesday 14th May will be considered.</strong></div><br> <div> </div><br> <div><strong>Interviews will be held as soon as possible thereafter. </strong></div> </div>Postdoctoral Research Associate
Closes: May 21, 2025, noon; salary: Research Grade 7: £38,674 – £46,913 per annum A less experienced candidate may be appointed at Research Grade 6 (£34,982 to £40,855) per annum, with a commensurate adjustment in either the essential criteria, responsibilities or duties.
<div> <p></p><div>We are seeking a highly motivated Postdoctoral Research Scientist with a strong background in human induced pluripotent stem cell (iPSC) differentiations and computational analysis to join Dr Ruxandra Dafinca’s group within the Nuffield Department of Clinical Neurosciences. </div><br> <div> </div><br> <div>The successful candidate will be responsible for leading a specific research project aimed at investigating local subcellular dysfunction in synapses of neurons from ALS/FTD patients using multi-omics. They will work under Dr Ruxandra Dafinca’s supervision (<a rel="nofollow" href="http://">https://www.ndcn.ox.ac.uk/team/ruxandra-dafinca</a> ) in a stimulating environment as part of the Oxford Motor Neuron Disease Centre and will be based in the Kavli Institute for Nanoscience Discovery. This is an exciting opportunity to contribute to the development of novel strategies for neuronal analysis in health and disease and optimizing novel methods. The project is funded by My Name’5 Doddie Foundation, as part of their Catalyst Awards. </div><br> <div> </div><br> <div>Using iPSC-neurons, our group aims to determine regulatory pathways affected by disease by implementing the use of spatial proteomics combined with transcriptomics and live imaging. The total proteome of a neuron includes a vast array of proteins involved in numerous cellular processes. This complexity can make it challenging to pinpoint disease-relevant changes. By narrowing the focus to the presynaptic proteome, we can reduce this complexity, making it easier to identify and study proteins that are directly involved in synaptic dysfunction. In this project, we will implement a novel spatial proteomics strategy to analyse the proteome of the organelles localized in the presynaptic areas of motor neurons from ALS patients and integrate the altered protein distributions with local transcriptomic changes. The overarching goal of our work is to identify new therapeutic targets that can inform drug development for ALS/FTD. </div><br> <div> </div><br> <div>Laboratory work will involve differentiations of human iPSCs to motor neurons, developing microfluidic and transwell culture systems, preparing samples for mass-spectrometry and RNA sequencing. Previous experience with complex in vitro culture systems, such as microfluidic chambers, is essential. It is also expected that the successful candidate will contribute to the computational analysis of multi-omic data that will be generated during the project. The candidate must hold or be near completion to a PhD/DPhil in Neuroscience/Biochemistry or relevant discipline and have excellent previous laboratory experience. The post-holder will also be expected to contribute to the training and mentoring of postgraduate students and junior members of the group. </div><br> <div> </div><br> <div>For any enquiries regarding the project, please contact Dr Ruxandra Dafinca (<a rel="nofollow" href="http://">Ruxandra.dafinca@ndcn.ox.ac.uk</a>).</div><br> <div> </div><br> <div>Please see the below 'Job Description' for further details on the responsibilities and selection criteria, as well as further information about the university and how to apply.</div><br> <div> </div><br> <div> </div><br> <div><strong>The post is full time for a fixed term, available from 18th August 2025 until 17th August 2026.</strong></div><br> <div> </div><br> <div><strong>Only applications received before 12.00 midday on Wednesday 21st May will be considered.</strong></div><br> <div> </div><br> <div><strong>Interviews will be held as soon as possible thereafter. </strong></div> </div>