Post-doctoral Research Assistant neuronal biologist: “Biomarkers of lysosomal dysfunction in Parkinson’s disease”

**Full-time, Fixed-term for 2 years**





Applications are invited for a post-doctoral neuronal biologist to work on
biomarker profiles of lysosomal dysfunction in pre-clinical models of
Parkinson’s. The project, funded by the Michael J Fox Foundation and in
collaboration with EndLyz, a new company within the Dementia Discovery Fund
(DDF) portfolio, represents an exciting opportunity to undertake translational
work at the interface between academic research and pharmaceutical target and
drug discovery in an exceptional setting. The project will examine metabolomic
biomarkers of endolysosomal dysfunction to better understand mechanisms of
disease pathology, and to establish how the biomarker profile may change on
treatment with potential therapeutic compounds.



Duties include design and implementation of experiments; interpretation of
data; metabolomic profiling in Parkinson’s transgenic mouse models;
biochemistry, immunohistochemistry and molecular neuropathology studies in
brain samples from transgenic mice; preparation of data for publication;
contribute ideas for new research projects and develop ideas for generating
research income; manage own academic research involving small-scale project
management and act as a source of information to other members of the group.



You will have excellent knowledge and practical experience of working with
pre-clinical transgenic models of neurodegenerative disease. The ability to
innovate, trouble-shoot technical problems, be meticulous in practical work
and in record keeping is also essential. Applicants must hold, or be near
completion of, a PhD/DPhil in a relevant area of research and have experience
in cellular neuroscience, and molecular cell biology relevant to analysis of
neuronal phenotypes.





The post is available for two years to start as soon as possible. The post
will be based in the Laboratory of Molecular Neurodegeneration, Kavli
Institute for Nanoscience Discovery, South Parks Road, Oxford, OX1 3PT.





Informal enquiries may be directed Professor Richard Wade-Martins
(richard.wade-martins@dpag.ox.ac.uk).





Closing date for applications is **midday on Thursday 11 April 2024.**





Interviews are likely to be held on the **week beginning 22 April 2024.**





Applications are particularly welcome from women, black and minority ethnic
candidates who are under-represented in academic posts in Oxford.





While this is a full-time role, we welcome applications from individuals who
wish to be considered for part-time working or other flexible working
arrangements.





We, as a Department and Community, will be considerate and welcoming of all
people, regardless of race, ethnicity, religion, disability, sexual
orientation and gender identity. We acknowledge societal inequalities and how
these impact us, and those around us, personally and professionally. – DPAG
Statement of Inclusion