Postdoctoral Research Associate in Cell Biology/Biochemistry

There is an exciting opportunity for a Postdoctoral Research Associate in Cell
Biology/Biochemistry in the Nuffield Department of Orthopaedics, Rheumatology
and Musculoskeletal Sciences (NDORMS) based at the Botnar Research Centre,
Oxford. The laboratory of Prof. John Christianson is seeking an exceptional,
enthusiastic, and motivated scientist to work on a research project
investigating protein degradation mechanisms in cancer. You will join an
interdisciplinary team of experimental scientists working in the fields of
cell biology and myeloma drug resistance as part of the Oxford Translational
Myeloma Centre.



In this role, you will be biochemically and functionally characterising
ubiquitin ligase complexes in the endoplasmic reticulum (ER), working with
both in vitro and cell culture systems. The research project will involve a
wide range of basic and advanced molecular/cellular biology and biochemical
techniques, including but not limited to; cell culture, genomic manipulation
(e.g. CRISPR), mass spectrometry, IP-WB, FACS, protein purification, and
radiolabelling. You will have previous laboratory experience, good
communication skills, and an ability to work both independently and as part of
a team. You will manage your own academic research and administrative
activities, while contributing to the dissemination of research group findings
by authorship of manuscripts, presentations at meetings, and the group’s
website.



We are seeking an individual with a PhD/DPhil (or be near completion) in Cell
Biology, Molecular Biology, Biochemistry or related discipline. Previous and
relevant experience in ubiquitin-proteasome biology, protein quality control,
or membrane protein biochemistry is essential. Experience in mass spectrometry
with complex samples, ER biology, ER-stress and the UPR, or background in
haematological cancer biology, is highly desirable.



This is a full-time fixed term (until December 2025) appointment.



The closing date for this position is 12 noon on 27/10/2023. You will be
required to upload a CV and supporting statement as part of your online
application.