Postdoctoral Researcher in genetic disorders of chromatin function

We have an exciting opportunity to recruit a Postdoctoral Researcher in
genetic disorders of chromatin function to join Dr Robert Beagrie’s Lab at the
Centre for Human Genetics, Nuffield Department of Medicine. This project will
involve investigating the consequences of mutations in _Nipbl_. Nipbl is
responsible for loading the cohesin complex onto chromatin and therefore has a
major role in establishing proper 3D chromatin folding.





The project aims to characterize the transcriptional, epigenetic, and
3D-chromatin consequences of Nipbl disruption using animal models and cell
lines. You will do this by applying advanced techniques including single-cell
RNA-seq, single-cell ATAC-seq, and Genome Architecture Mapping (GAM).





You will be responsible for contributing to the research group’s goal of
understanding how mutations in chromatin-organizing genes cause disease by
conducting laboratory experiments to test hypotheses, reviewing and refining
working hypotheses as appropriate, contributing ideas for new research
projects, and developing ideas for generating research income. You will be
tasked with keeping detailed, accurate, and comprehensible electronic records
of experimental and computational work and communicating progress and
difficulties in the research project to Dr. Beagrie and the wider research
group. Finally, you will also be responsible for managing your own academic
research and administrative activities, including small-scale project
management and coordinating multiple aspects of work to meet deadlines.





To be successful in this role, you will hold a PhD/DPhil (or be close to
completion) in biology, biochemistry, genetics, bioinformatics, or another
related subject, along with strong experience in chromatin organization, gene
regulation or congenital disease. You will have the ability to demonstrate a
clear interest in learning how to generate Genome Architecture Mapping data
and integrate it with single-cell and/or spatial transcriptomics data. You
will also have the ability to work collaboratively as part of a team and
manage the day-to-day running of a research project including assisting the
work of junior researchers.





Applications for this vacancy are to be made online and you will be required
to upload a supporting statement and CV as part of your online application.
Your supporting statement must explain how you meet each of the selection
criteria for the post using examples of your skills and experience.





This position is offered full-time on a fixed-term contract for 2 years and is
funded by Wellcome.





Only applications received before 12 midday on Friday 13 September 2024 will
be considered. Interviews to be held on Thursday 10 October. Please quote
**174376** on all correspondence.