Research Assistant

We have an exciting opportunity for a Research Assistant to join the research
group headed by Professor Geraldine Gillespie and Emeritus Professor Andrew
McMichael in the Nuffield Department of Medicine, Centre for Immuno-Oncology,
which carries out basic and translational immunological research on the non-
classical major histocompatibility molecule (MHC), HLA-E.





You will be responsible for establishing in vitro co-culture systems of
primary CD8+ T cells with 3D cultures of HPV-containing keratinocytes and
fibroblasts (e.g., spheroids or organotypic raft cultures) for testing
engineered T-cell therapies in pre-clinical proof-of-concept studies. You will
perform lab-based experimental work of a high standard, to carry our
techniques carefully and accurately and keeping good records of all work
performed. This work also includes contributing to presentation of research
reports and publications and smooth running of the laboratory ensuring that
work in the Department is conducted safely and legally.





It is essential that you hold a BSc degree in a relevant biomedical science
area together alongside experience with mammalian tissue culture and, ideally,
with establishing 3D tissue culture systems (e.g., spheroids or organoids).
You will also have experience in growing primary CD8+ T cells and T cell
lines. You will also have excellent communication skills and will be able to
work independently as well as part of a multidisciplinary team. Having
experience of working with murine tissue samples is desirable.





Applications for this vacancy should be made online and you will need to
upload a supporting statement and CV. Your supporting statement must explain
how you meet each of the selection criteria for the post using examples of
your skills and experience. Please restrict your documentation to your CV and
supporting statement only. Any other documents will be requested at a later
date.





This position is offered full time on a fixed term contract until 30 November
2026 and is funded by Bill and Melinda Gates Foundation.





Only applications received before 12 midday on Wednesday 11 June 2025 will be
considered. Please quote **179347** on all correspondence.