Postdoctoral Research Associate in Mechanisms of Cell Signalling

**Pay Scale:** STANDARD RESEARCH GRADE 7



**Salary ( £)**: £41,997 - £46,913 per annum



**Location:** Department of Biochemistry, South Parks Road, Oxford



**Contract type:** Fixed Term Contract for up to 3 years



**Hours:** Full Time (37.5 hours per week)





**About the role**





The Ranes lab are seeking a talented Postdoctoral Research Associate to
investigate the molecular mechanisms driving the Wnt/beta-catenin signalling
pathway at the plasma membrane. The lab undertakes a multidisciplinary
approach spanning biochemistry/biophysics, cell biology and structural biology
to address our research questions. In this role you will build on our previous
success in the biochemical reconstitution of beta-catenin destruction complex,
to investigate the mechanisms underpinning Wnt pathway activation and
termination at the plasma membrane using both _in vitro_ and cell-based
approaches. In this endeavour the position is for a Postdoc with expertise in
cell signalling pathways, protein biochemistry and _in vitro_ cell biology.
You will be responsible for studying the regulation and recruitment of
cytoplasmic signal transduction proteins to the Wnt receptor complexes using
state-of-the art tools and resources, such as _in vitro_ protein
reconstitution to dissect discreet transduction steps, CRISPR approaches and
super-resolution microscopy.





This full-time fixed-term post is funded by the Wellcome Trust for up to 3
years in the first instance.





The actual starting salary offered will be based on qualifications and
relevant skills acquired and will also be determined by the funding available.





**What We Offer**





Your happiness and wellbeing at work matters to us, so we offer a range of
family friendly and financial benefits including:





• An excellent contributory pension scheme



• 38 days annual leave



• A comprehensive range of childcare services



• Family leave schemes



• Cycle loan scheme



• Membership to a variety of social and sports clubs



• Discounted bus travel and Season Ticket travel loans





The University also runs an enormous amount of social groups and sports clubs
for those looking for more than just a great place to work.





**About you**





You will hold a PhD/DPhil or be near completion of a PhD/DPhil in
Biochemistry, Cell Biology or related discipline and have substantial
experience in basic molecular biology techniques in particular recombinant DNA
techniques. Experience in the expression and purification of recombinant
proteins as well as biochemical and biophysical characterisation methods are
essential. You will possess sufficient knowledge and experience in mammalian
cell culture and associated cell-based techniques and be able to demonstrate
strong organisational skills with the ability to prioritise and multitask lab
duties both independently and as part of a team. You will have excellent oral
and written communication skills, with the ability to write for publication
and present research proposals and results.





**Application Process**





Applications for this vacancy are to be made online via www.recruit.ox.ac.uk
and Vacancy ID **179455**. You will be required to upload your curriculum
vitae and a supporting statement, setting out how you meet the selection
criteria for the post, using examples of your skills and experience. As part
of your application, you will be asked to provide details of two referees and
indicate whether we can contact them now.





For further details, please refer to the How to apply section of the job
description. Any further enquires may be directed to
recruitment@bioch.ox.ac.uk.





The closing date for applications is **12.00 noon** on **Monday 2nd June
2025**. Only applications received before this time can be considered.
Interviews for shortlisted candidates to be held on as soon as possible
thereafter.





**Committed to equality and valuing diversity**