All vacancies within Department of Oncology

There are currently 5 vacancies within Department of Oncology:

Title	Closes	Salary
Group Leader in Immune Radiation Biology	Oct. 30, 2020, noon	Grade 10: £55,750 - £64,605 per annum (with discretionary scale to £70,579)
Group leader in Radiation Biology and Tumour Microenvironment	Oct. 30, 2020, noon	Grade 10: £55,750 - £64,605 per annum (with discretionary scale to £70,579)
Hyperpolarized Xe MRI Postdoctoral Researcher	Oct. 30, 2020, noon	Grade 7: £32,817 - £40,322 per annum
Postdoctoral Researcher in Cellular Pathway Responses to Radiotherapy	Oct. 30, 2020, noon	Grade 7: in the range of £32,817 to £40,322
Postdoctoral Researcher in Targeting Cancers Dependent on the Alternative Lengthening of Telomeres Pathway	Oct. 30, 2020, noon	Grade 7: in the range of £32,817 to £36,914 (up to first 5 points on scale available)

Group Leader in Immune Radiation Biology

Closes: Oct. 30, 2020, noon; salary: Grade 10: £55,750 - £64,605 per annum (with discretionary scale to £70,579)

<div> We have an opportunity for a new Group Leader, who will report to the Director of the Oxford Institute of Radiation Oncology. The postholder will be head of a significant research group focused on how radiation affects the immune response of tumours and will develop research questions and have the skills necessary to design and progress these questions in the laboratory, moving into clinical applications in due course and with collaborators, potentially translating them into clinical trials. The post holder will initiate and implement a long-term interdisciplinary research programme in the area of adaptive and immune biology and in combination with radiation therapy. They will also manage substantial research resources and budgets, generate research income and actively promote the research area and participate in the training and supervision of post-doctoral trainees, graduate students and junior scientists in the department. The post holder will be a recognised authority in their field and head a significant research group. The post holder will be expected to develop their own independent, innovative research programme, and will have responsibility for the development of its strategic direction, working in collaboration with both basic and translational groups in Oxford. The post holder will hold a relevant PhD/DPhil with significant post-qualification research experience and will have an established international publication record, as well as experience of managing research projects and staff. Specific expertise in translational research would be advantageous. This is a full time fixed term post until 31 March 2022 in the first instance. All applicants must complete an application form and upload a CV and supporting statement. Informal enquiries can be made to Dr Toni Fleming toni.fleming@oncology.ox.ac.uk The closing date for applications is 12.00 noon on 30 October 2020. </div>

Group leader in Radiation Biology and Tumour Microenvironment

Closes: Oct. 30, 2020, noon; salary: Grade 10: £55,750 - £64,605 per annum (with discretionary scale to £70,579)

<div> We have an opportunity for a new Group Leader, who will report to the Director of the Oxford Institute of Radiation Oncology (OIRO). The post holder will be expected to lead a programme of basic and translational cancer research within OIRO and will develop research questions and have the skills necessary to design and progress these questions in the laboratory, moving into clinical applications in due course and with collaborators, potentially translating them into clinical trials. The post holder will initiate and implement a long-term interdisciplinary research programme in the area of signal transduction in response to radiation therapy and/or the tumour microenvironment. They will also manage substantial research resources and budgets, generate research income and actively promote the research area and participate in the training and supervision of post-doctoral trainees, graduate students and junior scientists in the department. The post holder will have expertise in their field and head a significant research group or deputy director of a major research unit or centre. The post holder will be expected to develop their own independent, innovative research programme, and will have responsibility for the development of its strategic direction, working in collaboration with both basic and translational groups in Oxford. The post holder will hold a relevant PhD/DPhil with significant post-qualification research experience and will have a strong publication record. This is a full time fixed term post until 31 March 2022 in the first instance. All applicants must complete an application form and upload a CV and supporting statement. Informal enquiries can be made to Dr Toni Fleming toni.fleming@oncology.ox.ac.uk The closing date for applications is 12.00 noon on 30 October 2020. </div>

Hyperpolarized Xe MRI Postdoctoral Researcher

Closes: Oct. 30, 2020, noon; salary: Grade 7: £32,817 - £40,322 per annum

<div> We are looking for a postdoctoral researcher to join the Functional Imaging and Radiotherapy physics group headed by Prof Fergus Gleeson. You will provide physics support for clinical trials involving hyperpolarized xenon MRI. In collaboration with the Oxford Cancer Centre, the necessary hardware has been acquired and commissioned and exciting clinical trials of this relatively rare technique are already in progress. In addition to data acquisition and processing for trials in progress you will continue to develop implement and optimize imaging sequences and clinical protocols. You will have a PhD (or be near to completion) in physics, medical imaging or a related subject and have relevant experience in MRI. You will also have experience of successfully preparing and submitting scientific data for publication. The ability to work independently and using initiative is essential. This is a full-time post and is available for a fixed-term until 31st March 2022 in the first instance. All applicants must complete a short application form and upload a CV and supporting statement. The closing date for applications is 12:00 noon 30th October 2020. </div>

Postdoctoral Researcher in Cellular Pathway Responses to Radiotherapy

Closes: Oct. 30, 2020, noon; salary: Grade 7: in the range of £32,817 to £40,322

<div> We have an exciting new opportunity for a Postdoctoral Researcher in Cellular Pathway Responses to Radiotherapy. Reporting to Prof. Amato Giaccia, the Director of the Oxford Institute for Radiation Oncology, this position is funded by the MRC Unit of Radiation Oncology with the goal of identifying new cellular pathway responses to radiotherapy and understand their underlying mechanisms, with studies being performed in both tumour cells and healthy tissue. We are looking for a highly motivated postdoctoral researcher with experience in cell culture, molecular analysis of gene expression, signal transduction and pre-clinical tumour models. In particular, individuals with experience in performing large scale screens are encouraged to apply. The postholder will develop large scale screens to identify new loci and pathways involved in the response of cells to radiation given in different fraction sizes and dose rates, performing bioinformatic analysis of data generated during screens. You will test hypotheses and analyse scientific data from a variety of sources, reviewing and refining working hypotheses as appropriate. You will be expected to present detailed research proposals to senior researchers and collaborate in the preparation of scientific reports and journal articles, occasionally presenting papers and posters and participating in public engagement activities. Managing your own academic research and administrative activities, you will be able to co-ordinate multiple aspects of work to meet deadlines, carrying out research in a rigorous manner while also providing guidance to less experienced members of the research group. Some ad hoc teaching will be required. The successful candidate will hold, or be close to completing, a relevant PhD/DPhil in genetics, cell biology and tumour biology, together with relevant experience. You will possess sufficient specialist knowledge in the discipline to work within established research programmes, managing your own academic research and associated activities. Previous experience of contributing to publications/presentations and evidence of a strong publication record is essential. The post will be based in the Old Road Campus Research Building, Headington, Oxford, OX3 7DQ. The post is full time and fixed term until 31 March 2022. All applicants must complete an application form and upload a CV and supporting statement. Informal enquiries can be made to Dr Toni Fleming toni.fleming@oncology.ox.ac.uk The closing date for applications is 12:00 noon UK time on Friday 30 October 2020 Interviews are expected to take place on 24 November 2020. </div>

Postdoctoral Researcher in Targeting Cancers Dependent on the Alternative Lengthening of Telomeres Pathway

Closes: Oct. 30, 2020, noon; salary: Grade 7: in the range of £32,817 to £36,914 (up to first 5 points on scale available)

<div> We have an exciting new opportunity for a Postdoctoral Researcher to join a research group on a collaborative project between the University of Oxford and Merck Healthcare, reporting to Dr David Clynes in the Cancer Therapeutics, DNA Damage and Repair laboratory. The aim of the laboratory is to explore the mechanism by which a subset of cancers achieve immortality through the aberrant lengthening of their chromosome ends (telomeres) via a pathway known as the Alternative Lengthening of Telomeres (ALT). The lab further aims to exploit this knowledge for therapeutic benefit. The postholder will lead a project aimed of identifying novel targets and small molecules for the selective targeting of cancer cells dependent on the ALT pathway. You will be required to develop novel screening platforms using CRISPR-Cas9 genome engineering technologies and optimise a variety of markers to gauge the ability of a given small molecule to confer synthetic lethality in the context of a positive ALT pathway. Collaborating with researchers from across the University of Oxford's various technology platforms, the postholder will review and test hypotheses, generating high-quality, reproducible data in a format suitable for publication, presentation and submission for grant applications to generate research income. You will maintain accurate recording of samples, reagents and all experiments undertaken in a designated electronic lab notebook. You will be expected to collaborate in the preparation of scientific reports and journal articles and occasionally present papers and posters, representing the research group at national/international meetings as required. In addition to managing their own research and administrative activities, the postholder will be expected to provide guidance to less experienced members of the research group, and assist with the peer review of manuscripts and grant applications. The successful candidate will hold, or be close to completing, a relevant PhD/DPhil in cell biology, molecular biology or other relevant field, with previous experience in basic molecular biology techniques, including mammalian tissue culture. A background in telomere biology (in particular the ALT pathway), genome stability, or related areas of chromosome biology is essential, together with demonstrable experience of contributing to publications/presentations. Excellent communication skills, including the ability to write for publication, present research proposals and results, and willingness to represent the research group at meetings, is required for this role. The post will be based in the Weatherall Institute of Molecular Medicine (WIMM), John Radcliffe Hospital, Headington, Oxford, OX3 9DS and is offered on a full-time, fixed-term basis for 2 years. Prospective candidates are encouraged to send informal enquiries to Dr David Clynes (david.clynes@oncology.ox.ac.uk) before applying. The closing date for applications is 12:00 noon UK time on Friday 30 October 2020. Interviews are expected to take place on 17 November 2020. </div>