Data.ox is deprecated. Advanced notice of its end of life date will be advised in due course via this site and the ITSS mail list.
Vacancies within Wellcome Trust Centre for Human Genetics
There are currently 5 vacancies within Wellcome Trust Centre for Human Genetics:
| Title | Closes | Salary |
|---|---|---|
| Senior Statistical Geneticist | June 17, 2025, noon | Standard Grade 8: Standard Grade 8: £48,235 - £ 57,255 with a discretionary range to £62,407 p.a. (pro rata). This is inclusive of a pensionable Oxford University Weighting of £1,500 per year (pro rata). |
| Research Assistant in Functional Genomics of Sepsis | June 23, 2025, noon | Research Grade 6: Research Grade 6: Salary in range £34,982 - £40,855 per annum |
| Bioinformatician | June 24, 2025, noon | Grade 7: £38,674 - £46,913 with a discretionary range to £51,059 p.a. This is inclusive of a pensionable Oxford University Weighting of £1,500 per year. |
| Postdoctoral Scientist: Bioengineering of iPSCs and transcriptomics of derived neurons | June 24, 2025, noon | Research Grade 7: Research Grade 7: Salary in range £38,674 - £44,382 per annum. This is inclusive of a pensionable Oxford University Weighting of £1,500 per year |
| Postdoctoral Research Assistant in Cancer Biology | June 30, 2025, noon | Research Grade 7: Research Grade 7: Salary in range £38,674 - £46,913 per annum. This is inclusive of a pensionable Oxford University Weighting of £1,500 per year |
Senior Statistical Geneticist
Closes: June 17, 2025, noon; salary: Standard Grade 8: Standard Grade 8: £48,235 - £ 57,255 with a discretionary range to £62,407 p.a. (pro rata). This is inclusive of a pensionable Oxford University Weighting of £1,500 per year (pro rata).
<div> <p></p><div>The Oxford-GSK Institute of Molecular & Computational Medicine is a multidisciplinary programme aiming to improve tools in, and knowledge from, genetics, genomics, molecular and single cell biology, spatial imaging, machine learning and novel methods of data handling to study the pattern of diseases in new ways.</div><br> <div> </div><br> <div>The Institute has an exciting opportunity for a Senior Statistical Geneticist to join the team.</div><br> <div> </div><br> <div>You will lead in the design and implementation of statistical and computational algorithms of different datasets, and implement novel algorithms within the framework of existing code, providing documentation and user support. You will be responsible for leading statistical analysis of numerous projects and you will work closely with other project members to develop software packages and workflows. Where appropriate, you will train others in the use of software developed during the course of the projects. Other responsibilities will include keeping meticulous, detailed records of your work and committing to performing cloud-based analyses on the IMCM data platform, identifying and troubleshooting technical or scientific problems, and working collaboratively with the IMCM bioinformatics core group to overcome issues.</div><br> <div> </div><br> <div>It is essential that you hold a PhD/DPhil in a relevant subject area (e.g. computer science, bioinformatics, mathematics, medical statistics, statistics). You will have extensive knowledge and working understanding of statistical concepts and tools, including Mendelian randomisation, and expertise in one or more programming languages (for example bash, R, C, Python). Experience handling and analysing various types of ‘omics data types, such as RNA-Seq, whole genome or exome sequencing data, single cell profiling, ChIP-Seq, proteomics, and metabolomics is essential for this role, along with strong interpersonal skills and ability to contribute to a supportive, helpful culture and work very closely with end users. Previous experience of working on neuroscience projects, such as on Parkinson’s disease, Alzheimer’s disease, ALS or another neurodegenerative disease would be highly desirable for this position.</div><br> <div> </div><br> <div>Applications for this vacancy are to be made online and you will be required to upload a supporting statement and CV as part of your online application. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience.</div><br> <div> </div><br> <div>This position is offered full time on a fixed term contract until 30 September 2027 and is funded by GSK.</div><br> <div> </div><br> <div>Interviews will be held on the 24, 25, 26 June 2025. </div><br> <div> </div><br> <div>Only applications received before 12 midday on 17 June 2025 will be considered. Please quote <strong>178513</strong> on all correspondence.</div><br> <div> </div><br> <div>Previous applicants need not apply.</div> </div>Research Assistant in Functional Genomics of Sepsis
Closes: June 23, 2025, noon; salary: Research Grade 6: Research Grade 6: Salary in range £34,982 - £40,855 per annum
<div> <p></p><div>Previous applicants need not re-apply.</div><br> <div> </div><br> <div>Applications are invited for a Research Assistant in Functional Genomics of Sepsis to join Professor Julian Knight’s research group, an established team with a track record of innovation and high impact research in functional genomics, sepsis and susceptibility to multi-factorial disease.</div><br> <div> </div><br> <div>This is an exciting new position funded through a collaboration with the Danaher corporation and its subsidiary Cepheid. This research is part of the Beacon programme ‘Development and prospective evaluation of point-of-need test for sepsis subtyping based on gene expression using the Cepheid GeneXpert platform’. The programme seeks to advance precision medicine for patients with sepsis by developing a point-of-care test to stratify patients based on their immune response profiles. We aim to use an integrated approach which leverages the host transcriptome, immune profiling, and electronic health records, in combination with the GeneXpert system for mRNA quantification. Our goal is to deliver a precision medicine approach for managing patients with severe infections. The work is highly collaborative with clinical teams, company partners, and expert investigators across the UK, the US, and Sweden. You will facilitate exciting new collaborative links with Danaher, which may involve travel to Sweden (Cepheid) and the United States (Danaher).</div><br> <div> </div><br> <div>You will have a degree in biology, genetics, immunology, biochemistry, molecular biology or related field and relevant research experience of patient blood or tissue sample processing in the laboratory and management of sample collections.</div><br> <div> </div><br> <div>You will be motivated by a stimulating and ambitious research environment with a desire to deliver high quality cutting-edge science and work in a laboratory offering the opportunity for career development and acquiring new expertise.</div><br> <div> </div><br> <div>This position is offered full time on a fixed term contract until 30 September 2027 and is funded by the Danaher Corporation. The anticipated start date is 1 September 2025.</div><br> <div> </div><br> <div>Applications for this vacancy should be made online and you will need to upload a supporting statement and CV. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. Please restrict your documentation to your CV and supporting statement only. Any other documents will be requested at a later date.</div><br> <div> </div><br> <div>Only applications received before 12 midday on 23 June 2025 can be considered. Please quote 179416 on all correspondence.</div> </div>Bioinformatician
Closes: June 24, 2025, noon; salary: Grade 7: £38,674 - £46,913 with a discretionary range to £51,059 p.a. This is inclusive of a pensionable Oxford University Weighting of £1,500 per year.
<div> <p></p><div>We are seeking to appoint a Bioinformatician to join the multidisciplinary Oxford-GSK Institute of Molecular & Computational Medicine (IMCM), operating within the Nuffield Department of Medicine (NDM). The Institute brings together the very best scientific, clinical, technological and computational expertise from Oxford University and GSK forming a unique industry/academic partnership. The aim of the Institute is to improve tools in, and knowledge from, genetics, genomics, molecular and single cell biology, spatial imaging, machine learning and novel methods of data handling to study the pattern of diseases in new ways.</div><br> <div> </div><br> <div>Within this role, you will be responsible for conducting processing and detailed analysis for the different Oxford-GSK IMCM projects, working on various ‘omics datasets, including transcriptomic, genomic, proteomic and metabolomic data, as well as imaging and clinical data. You will contribute to the development of new pipelines or optimise existing ones as required, working closely and collaboratively with other members of the bioinformatics team. Committing to performing cloud-based analyses on the IMCM data platform is a key part of this role, along with preparing manuscripts for publication and contributing to written and oral presentations/reports as required.</div><br> <div> </div><br> <div>This is an exciting role in which you will be in regular communication with the Oxford-GSK IMCM project leads and will work collaboratively with the Oxford-GSK IMCM Fellows and other researchers in the institute, keeping in mind the Oxford-GSK IMCM’s approach and mission.</div><br> <div> </div><br> <div>It is essential that you hold a relevant post-graduate qualification in bioinformatics, computational biology, biostatistics, applied mathematics, or related discipline, and have demonstrable experience in handling and analysing various types of ‘omics data types, such as RNA-Seq, whole genome or exome sequencing data, single cell profiling, ChIP-Seq, proteomics, and metabolomics.</div><br> <div> </div><br> <div>If you have a strong ability to plan and oversee programmes of technical work to a successful conclusion by agreed deadlines and the ability to contribute to a supportive, helpful culture working closely with end users, this role may be for you!</div><br> <div> </div><br> <div>Applications for this vacancy should be made online and you will need to upload a supporting statement and CV. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. Please restrict your documentation to your CV and supporting statement only. Any other documents will be requested at a later date.</div><br> <div> </div><br> <div>This position is offered full time on a fixed term contract until 30 September 2027 and is externally funded by GSK.</div><br> <div> </div><br> <div>Only applications received before 12 midday on 24 June 2025 will be considered. Please quote <strong>179873</strong> on all correspondence.</div> </div>Postdoctoral Scientist: Bioengineering of iPSCs and transcriptomics of derived neurons
Closes: June 24, 2025, noon; salary: Research Grade 7: Research Grade 7: Salary in range £38,674 - £44,382 per annum. This is inclusive of a pensionable Oxford University Weighting of £1,500 per year
<div> <p></p><div>Are you a highly motivated Postdoctoral Research Scientist with a strong background in human induced pluripotent stem cell (iPSC) differentiation?</div><br> <div> </div><br> <div>We have an exciting opportunity for you to join Dr Martina Hallegger’s group at the Centre for Human Genetics, Nuffield Department of Medicine as a Postdoctoral Research Scientist.</div><br> <div> </div><br> <div>You will be responsible for the culture/characterisation of iPSC-derived neuronal models, and for generating novel cell lines with mutations in TARDBP (gene coding for TDP-43) using CRISPR-Cas9 genome editing. You will utilise bulk, long-read and iCLIP RNA-sequencing approaches to look at gene expression and regulation changes to identify proteins/pathways linked to the change in TDP-43 assembly behaviour. Other duties will include undertaking cellular and biochemical assays using advanced techniques in cell and molecular biology and cell imaging, and data analysis and interpretation of datasets (with support from local specialist bioinformatics and imaging teams). You must have strong teamwork, project management and interpersonal skills.</div><br> <div> </div><br> <div>It is essential that you hold a PhD/DPhil (or close to completion) in Neuroscience, Biology, Molecular Biology, or a related area, and have research experience in human-induced pluripotent stem cell-derived neuronal models. You will have experience with CRISPR-Cas9 gene editing and genome engineering and the validation of generated cell lines, and experience in cell culture, molecular and cell biology, protein biochemistry and setting up cellular assays. It is essential you have experience in transcriptomics and basic bioinformatic analysis, and a working knowledge of relevant analysis and statistical programs (eg. Fiji, CellProfiler, Adobe Photoshop/Illustrator, GraphPad Prism, RStudio).</div><br> <div> </div><br> <div>Applications for this vacancy should be made online and you will need to upload a supporting statement and CV. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. Please restrict your documentation to your CV and supporting statement only. Any other documents will be requested at a later date.</div><br> <div> </div><br> <div>This position is offered full time on a fixed term contract until 31 March 2028 and is funded by the My Name'5 Doddie Foundation.</div><br> <div> </div><br> <div>Only applications received before 12 midday on 24 June 2025 will be considered. Please quote <strong>180141</strong> on all correspondence.</div> </div>Postdoctoral Research Assistant in Cancer Biology
Closes: June 30, 2025, noon; salary: Research Grade 7: Research Grade 7: Salary in range £38,674 - £46,913 per annum. This is inclusive of a pensionable Oxford University Weighting of £1,500 per year
<div> <p></p><div>We are seeking an enthusiastic and motivated Postdoctoral Research Assistant in Cancer Biology to join the GO-PRECISE CRC-VAX project, a highly exciting initiative funded by GlaxoSmithKline (GSK), based at the Centre for Human Genetics, University of Oxford. The post aims to assist with the preparation and molecular characterisation of tumours using multi-omic analysis focusing principally on the mechanisms and consequences of immune escape in colorectal cancers (CRC) and pre-cancers.</div><br> <div> </div><br> <div>You will manage your own academic research and administrative activities. This involves small scale project management, to co-ordinate multiple aspects of work to meet deadlines. You will undertake laboratory work as required, such as sample preparation, cell culture, analysis of tumour samples and, tissue staining. Other responsibilities include testing hypotheses and analysing scientific data from a variety of sources, including sequencing and transcriptomics (including spatial transcriptomics), reviewing and refining working hypotheses as appropriate, and contributing ideas for new research projects.</div><br> <div> </div><br> <div>It is essential that you hold a PhD/DPhil (or close to completion) in a relevant scientific discipline such as molecular biology, genetics or other related discipline, and have experience of the genetic/molecular analysis of human diseases, such as cancer. You will be able to work with a high degree of independence, to learn rapidly and to master several laboratory techniques, and to commit to high standards, including record keeping and laboratory management. Basic bioinformatics skills or a willingness to learn them, and an understanding or interest in spatial biology procedures is highly desirable for this position.</div><br> <div> </div><br> <div>Applications for this vacancy should be made online and you will need to upload a supporting statement and CV. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. Please restrict your documentation to your CV and supporting statement only. Any other documents will be requested at a later date.</div><br> <div> </div><br> <div>This position is offered full time on a fixed term contract until 31 December 2027 and is funded by GSK.</div><br> <div> </div><br> <div>Only applications received before 12 midday on 30 June 2025 will be considered. Please quote <strong>178284</strong> on all correspondence.</div> </div>