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Vacancies within Wellcome Trust Centre for Human Genetics
There are currently 6 vacancies within Wellcome Trust Centre for Human Genetics:
| Title | Closes | Salary |
|---|---|---|
| Cellular Imaging Core Facility Assistant Manager | May 1, 2025, noon | Standard Grade 8: Standard Grade 8: £48,235 - £57,255 with a discretionary range to £62,407 p.a |
| Business Manager - Centre for Human Genetics | May 6, 2025, noon | Standard Grade 9: Standard Grade 9: £55,636 - £64,228 with a discretionary range to £70,029 p.a. (pro rata). This is inclusive of a pensionable Oxford University Weighting of £1,500 per year (pro rata) |
| Research Assistant in Functional Genomics of Sepsis | May 8, 2025, noon | Research Grade 6: Research Grade 6: Salary in range £34,982 - £40,855 per annum |
| Postdoctoral Research Assistant in Quantitative Spatial Data Analysis for Colorectal Precancer | May 12, 2025, noon | Research Grade 7: Research Grade 7: salary in range £38,674 - £46,913 p.a. This is inclusive of a pensionable Oxford University Weighting of £1,500 per year |
| Postdoctoral Research Assistant in the Interpretation of Spatial Transcriptomics and Proteomics for Colorectal Cancer | May 12, 2025, noon | Research Grade 7: Research Grade 7: salary in range £38,674 - £43,171 p.a. This is inclusive of a pensionable Oxford University Weighting of £1,500 per year |
| Postdoctoral Researcher in Neuronal Dysfunction in Alzheimer’s Disease, Oxford-GSK Institute of Molecular and Computational Medicine | May 22, 2025, noon | Research Grade 7: Research Grade 7: Salary in range £38,674 - £46,913 per annum. |
Cellular Imaging Core Facility Assistant Manager
Closes: May 1, 2025, noon; salary: Standard Grade 8: Standard Grade 8: £48,235 - £57,255 with a discretionary range to £62,407 p.a
<div> <p></p><div>Calling all microscopists!  We are looking to a recruit an enthusiastic Assistant Manager to the growing Cellular Imaging Core Facility at the Centre for Human Genetics.</div><br> <div> </div><br> <div>This role will centre around cutting-edge light microscopy. Once in post, you will provide support to users of the Cellular Imaging Core Facility, training them in a range of microscopy techniques at the appropriate level for the user and their project requirements. The Cellular Imaging Core Facility takes a holistic approach to microscopy training and education, as such you will have the knowledge and experience to advise on sample preparation, imaging modalities and settings, data processing, as well as image analysis and data presentation. You will lead in the development of bespoke analysis pipelines and train users in the independent use of analysis platforms with a focus on ZEISS arivis Pro.</div><br> <div> </div><br> <div>In addition to overseeing the use of microscopes within the Core, you will carry out system performance tests and liaise proactively with service engineers and/or company representatives in case of malfunction or underperformance. You will support the day to day running and administration of the Core, generating training materials, assisting with the instrument booking system and facility finances (including user recharges).</div><br> <div> </div><br> <div>It is essential that you hold a PhD/DPhil (or close to completion) in biological sciences, biophysics, or any other suitable discipline relevant to the role, and have significant knowledge and experience of light microscopy (confocal, widefield, Airyscan, SIM etc). You will have experience in live cell imaging and be familiar with the principles underlying a diverse range of optical microscopy techniques. It is essential you have experience teaching fundamental principles of microscopy to a varied audience, and experience in image data analysis with commercial and open-source image analysis packages.</div><br> <div> </div><br> <div>This is an exciting opportunity with the potential to collaborate on projects across a wide range of biological research themes utilising some of the most advanced microscopy equipment in the University of Oxford.</div><br> <div> </div><br> <div>Applications for this vacancy should be made online and you will need to upload a supporting statement and CV. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. Please restrict your documentation to your CV and supporting statement only. Any other documents will be requested at a later date.</div><br> <div> </div><br> <div>This position is offered full time on a fixed term contract for 2 years and is funded by the Department.</div><br> <div> </div><br> <div>Only applications received before 12 midday on 1 May 2025 will be considered. Please quote <strong>179269</strong> on all correspondence.</div><br> <div> </div><br> <div>For informal enquiries relating to this role please contact the Cellular Imaging Core Facility Head (Dr James Bancroft) at james.bancroft@well.ox.ac.uk.</div> </div>Business Manager - Centre for Human Genetics
Closes: May 6, 2025, noon; salary: Standard Grade 9: Standard Grade 9: £55,636 - £64,228 with a discretionary range to £70,029 p.a. (pro rata). This is inclusive of a pensionable Oxford University Weighting of £1,500 per year (pro rata)
<div> <p></p><div>Are you looking for a new and unique challenge? Do you have a strategically commercial mind with an interest in clinical research? Working in the University’s largest department, the role of Business Manager will take ownership of the provision of strategic leadership and relationship management for the Centre for Human Genetics, the Division of Structural Biology, as well as across the Nuffield Department of Medicine and wider University.</div><br> <div> </div><br> <div>Demonstrating strong leadership, influencing and commercial skills, the Business Manager has accountability for the co-ordination and delivery of high-quality teaching and research support within their assigned research unit. The successful candidate will be the interface between professional services and the academic community, and is responsible for ensuring the alignment of support to advance the academic strategy and vision. Working with the Directors and Finance and Operations and Professional Services Heads of Function, you will define strategic and operational priorities, drive improvements, and manage the escalation of issues through to resolution, ensuring academics receive a positive experience.</div><br> <div> </div><br> <div>You will come from a varied senior operational background, including management of a diverse range of administrative staff, ideally in a higher education, public sector or other large and complex organisation. The successful candidate will have a strong understanding of financial management and analysis as well as experience of people management and good HR practice. You will come armed with strong interpersonal skills, with the ability to communicate effectively with a wide range of people, and proven ability to lead, manage change and develop people. The ability to work under pressure with excellent prioritisation skills will be critical to this role, as well as excellent IT skills and expertise in the use of spreadsheets and databases.</div><br> <div> </div><br> <div>Applications for this vacancy should to be made online. You will need to upload a supporting statement and CV as part of your online application.  Your supporting statement should explain how you meet each of the selection criteria for the post, giving examples of your skills and experience.</div><br> <div>Our position is offered on a permanent and full time basis. You can expect positive support for your continued professional development through our Personal Development Review process. The University also offers a wide range of staff benefits, including entry to the generous USS pension scheme.</div><br> <div> </div><br> <div>Only applications received before 12 midday on <strong>6th</strong><strong> May 2025</strong> will be considered. Interviews will be held during week commencing 12th May 2025. Please quote 178753 on all correspondence.</div> </div>Research Assistant in Functional Genomics of Sepsis
Closes: May 8, 2025, noon; salary: Research Grade 6: Research Grade 6: Salary in range £34,982 - £40,855 per annum
<div> <p></p><div>Applications are invited for a Research Assistant in Functional Genomics of Sepsis to join Professor Julian Knight’s research group, an established team with a track record of innovation and high impact research in functional genomics, sepsis and susceptibility to multi-factorial disease.</div><br> <div> </div><br> <div>This is an exciting new position funded through a collaboration with the Danaher corporation and its subsidiary Cepheid. This research is part of the Beacon programme ‘Development and prospective evaluation of point-of-need test for sepsis subtyping based on gene expression using the Cepheid GeneXpert platform’. The programme seeks to advance precision medicine for patients with sepsis by developing a point-of-care test to stratify patients based on their immune response profiles. We aim to use an integrated approach which leverages the host transcriptome, immune profiling, and electronic health records, in combination with the GeneXpert system for mRNA quantification. Our goal is to deliver a precision medicine approach for managing patients with severe infections. The work is highly collaborative with clinical teams, company partners, and expert investigators across the UK, the US, and Sweden. You will facilitate exciting new collaborative links with Danaher, which may involve travel to Sweden (Cepheid) and the United States (Danaher).</div><br> <div> </div><br> <div>You will have a degree in biology, genetics, immunology, biochemistry, molecular biology or related field and relevant research experience of patient blood or tissue sample processing in the laboratory and management of sample collections.</div><br> <div> </div><br> <div>You will be motivated by a stimulating and ambitious research environment with a desire to deliver high quality cutting-edge science and work in a laboratory offering the opportunity for career development and acquiring new expertise.</div><br> <div> </div><br> <div>This position is offered full time on a fixed term contract until 30 September 2027 and is funded by the Danaher Corporation. The anticipated start date is 1 September 2025.</div><br> <div> </div><br> <div>Applications for this vacancy should be made online and you will need to upload a supporting statement and CV. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. Please restrict your documentation to your CV and supporting statement only. Any other documents will be requested at a later date.</div><br> <div> </div><br> <div>Only applications received before 12 midday on 8 May 2025 can be considered. Please quote 179416 on all correspondence.</div> </div>Postdoctoral Research Assistant in Quantitative Spatial Data Analysis for Colorectal Precancer
Closes: May 12, 2025, noon; salary: Research Grade 7: Research Grade 7: salary in range £38,674 - £46,913 p.a. This is inclusive of a pensionable Oxford University Weighting of £1,500 per year
<div> <p></p><div>We have an exciting opportunity for a Postdoctoral Research Assistant in Quantitative Spatial Data Analysis for Colorectal Precancer to join the multidisciplinary GO-PRECISE colorectal precancer team based at the Nuffield Department of Medicine, University of Oxford.</div><br> <div> </div><br> <div>GlaxoSmithKline and Oxford University (GO) launched the PRECISE Alliance (Pre-Cancer Biology and Immunoprevention) in 2024, with the aim of conducting deep exploration of cancer precursors (precancers) to identify their molecular vulnerabilities and developing methods to intercept them. The alliance is directed by Professor Sarah Blagden. This post is within the colorectal precancer theme which is jointly led by Simon Leedham and David Church.</div><br> <div> </div><br> <div>You will be responsible for managing your own academic research and administrative activities, and adapting existing mathematical and statistical methods for analysis of high-dimensional imaging data, and developing new ones. Other responsibilities will include analysing quantitative imaging data from a variety of sources, including Spatial Transcriptomics and multiplex Spatial Proteomics platforms and developing skills in computational biology and mathematical spatial analysis via independent study and training courses.</div><br> <div> </div><br> <div>It is essential that you hold a PhD/DPhil (or close to completion) in mathematics, statistics, physics, engineering, data science or a related discipline, and have demonstrated ability to analyse and interpret complex multidimensional data. Experience of programming in Python, or demonstrated ability to rapidly acquire fluent knowledge of new programming languages, libraries, and platforms is essential for this role, along with a strong interest in interdisciplinary research in the biological and medical sciences. Experience of applying software engineering best practices and experience of working with biomedical datasets, particularly cancer data and/or spatial data would be highly desirable for this position.</div><br> <div> </div><br> <div>Applications for this vacancy are to be made online and you will be required to upload a supporting statement and CV, and 2 referees as part of your online application. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience.</div><br> <div> </div><br> <div>This position is offered full time on a fixed term contract until 31 December 2027 and is funded by GlaxoSmithKline.</div><br> <div> </div><br> <div>Only applications received before 12 midday on 12 May 2025 will be considered. Please quote <strong>178283</strong> on all correspondence.</div> </div>Postdoctoral Research Assistant in the Interpretation of Spatial Transcriptomics and Proteomics for Colorectal Cancer
Closes: May 12, 2025, noon; salary: Research Grade 7: Research Grade 7: salary in range £38,674 - £43,171 p.a. This is inclusive of a pensionable Oxford University Weighting of £1,500 per year
<div> <p></p><div>We have an exciting opportunity for a Postdoctoral Research Assistant in the Interpretation of Spatial Transcriptomics and Proteomics for Colorectal Cancer. You will join the GO-PRECISE team at the Nuffield Department of Medicine, University of Oxford.</div><br> <div> </div><br> <div>GlaxoSmithKline and Oxford University (GO) launched the PRECISE Alliance (Pre-Cancer Biology and Immunoprevention) in 2024, with the aim of conducting deep exploration of cancer precursors (precancers) to identify their molecular vulnerabilities and developing methods to intercept them. The alliance is led by Professor Sarah Blagden.</div><br> <div> </div><br> <div>You will be responsible for managing your own academic research and administrative activities and adapting existing and developing new research methodologies and materials. You will analyse quantitative data from a variety of sources, particularly from Spatial Transcriptomics and Spatial Proteomics platforms, and collaborate with colleagues from the Mathematical Institute, Centre for Human Genetics, and the GO-PRECISE Alliance. Other duties will include contributing to community activities such as seminars and networking events and developing skills in many areas of computational biological research via independent study and training courses.</div><br> <div> </div><br> <div>It is essential that you hold a PhD/DPhil (or close to completion) in experimental or theoretical biology, bioinformatics, clinical medicine, or a related discipline and have demonstrated ability to analyse and interpret complex multidimensional data. You will have experience of working with biomedical datasets, such as cancer data and/or spatial data, and experience of programming in Python, or demonstrated ability to rapidly acquire fluent knowledge of new programming languages, libraries, and platforms. A background and/or interest in mathematics or computer science would be highly desirable.</div><br> <div> </div><br> <div>Applications for this vacancy are to be made online and you will be required to upload a supporting statement and CV, and 2 referees as part of your online application. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience.</div><br> <div> </div><br> <div>This position is offered full time on a fixed term contract until 31 December 2027 and is funded by GlaxoSmithKline.</div><br> <div> </div><br> <div>Only applications received before 12 midday on 12 May 2025 will be considered. Please quote <strong>178278</strong> on all correspondence.</div> </div>Postdoctoral Researcher in Neuronal Dysfunction in Alzheimer’s Disease, Oxford-GSK Institute of Molecular and Computational Medicine
Closes: May 22, 2025, noon; salary: Research Grade 7: Research Grade 7: Salary in range £38,674 - £46,913 per annum.
<div> <p></p><div>The Oxford-GSK Institute of Molecular & Computational Medicine has a new and exciting opportunity for a Postdoctoral Researcher, specialising in Neuronal Dysfunction in Alzheimer’s Disease, to join the Institute.</div><br> <div> </div><br> <div>The Institute is built around Fellows and Oxford-GSK project teams located across different departments within the Medical Sciences Division. Projects will initially focus on neurodegeneration and the central nervous system, specifically Alzheimer’s disease, Parkinson’s disease and amyotrophic lateral sclerosis but it is anticipated the range of activities will expand into other research areas in future.</div><br> <div> </div><br> <div>Based within the group of Dr Hugo Fernandes at the Department of Physiology, Anatomy and Genetics, you will be responsible for designing, validating, troubleshooting, and performing relevant assays to interrogate dysregulation induced in iPS-neurons by exposure to material from Alzheimer’s brains. You will develop an iPS-neuronal-microglial co-culture screening platform that can assess synaptic function and synaptic loss, and keep meticulous, detailed records of your work and commit to engaging with cloud-based analyses on the IMCM data platform. Other duties will include collaborating with peer scientists from cross-functional teams to analyse and interpret large complex datasets and communicate findings, and promoting the Oxford-GSK IMCM locally and nationally and disseminating research outcomes to advance knowledge in the specialist area.</div><br> <div> </div><br> <div>It is essential that you hold a PhD/DPhil (or close to completion) in biochemistry, molecular biology, neuroscience or a related field, and have experience in cell culture, preferably human pluripotent stem cells. You will have knowledge of neurodegenerative diseases, such as Alzheimer’s Disease, and of differentiation of iPSCs into neuronal and glial cultures. Experience in molecular biology methodologies, following and adapting protocols and setting up cellular assays including image-based is essential for this role, and knowledge of neuroinflammation would be highly desirable.</div><br> <div> </div><br> <div>Applications for this vacancy should be made online and you will need to upload a supporting statement and CV. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. Please restrict your documentation to your CV and supporting statement only. Any other documents will be requested at a later date.</div><br> <div> </div><br> <div>This position is offered full time on a fixed term contract until 30 September 2027 and is funded by GSK.</div><br> <div> </div><br> <div>Interviews will be held on 4 June 2025.</div><br> <div> </div><br> <div>Only applications received before 12 midday on 22 May 2025 will be considered. Please quote <strong>179348</strong> on all correspondence.</div> </div>